yes, I looked at that mini pump a few months back, and yeah, I know it's marginally better...I mean, it is the best really if you can bear an apparatus.
nygirl, it's really not hard at all. Look, the verdicts were in long ago that daily interferon had better result WHEN folks were compliant.
only WHEN, when is the key word.
some folks are afraid of shots, some aren't. I've had to do dailt injections for years now, so it takes me like maybe 60 seconds to whip out a syringe and pop my belly...one advantage to pinching more than an inch, belly fat has very few nerves, grin.
my reasoning is very sound here, the interferon only stays in the system for 8 hours, even still in countries where daily INF is still used the rates of compliant patients is higher than for peg. peg is only higher where you see non-compliance.
now my issue was why are they allowing for the 4 hour window with NO interferon?
if they are getting higher better stats with the daily injections over the weekly, it's because the peg end of week fall off is too great. Onviously the steadier the state the better.
ergo if you eliminate the 4 hour empty window, and go to every 8 hours, you'd at least be eliminating those times of NO interferon. you still are getting a higher level the first of the 4 hours and less high the second 4, but you would increase to almost steady state.
I like your guy's idea though of the mini, and think maybe the external pump for the first couple months might be doable....it would give optimum coverage, then maybe I'd switch to shots after getting UND when it wouldn't be quite so crucial.
I thought this would lower chance of infection because if the blood tanks like last time that could be a big issue (I got several infections last time, remember?).
But the blood won't take completely for a while, so it sounds good.
Not sure I'd want to do the whole year....I had to wear a heart monitor a while back...and it drove me batty in those 2 days...a whole year of that..yikes.
I suppose I should just ask for the pump though and then switch, if I tell them I just want it for the first couple months it would never get approved.
using an insulin pump to maintain interferon levels is a wonderful idea. a diabetic nurse educator will be able to show you how to insert the cannula and maintain the pump.
btw here is the current announcement for the medtronic mini med pump trial for HCV
http://clinicaltrials.gov/ct2/show/NCT00919633
I can read the time stamp on your posts and know your sleep patterns are not those of mere mortals ;-) You're in good company along with Thomas Edison and other creative thinkers.
As to insulin pumps:
First, note they were using an *external* pump w/subQ injection.
Second, like the three-part-non-invasive blood test for occult HCV, it's too cutting edge to be commercially available yet, anyway. You'd have a hard time finding anyone to do the procedure.
Just trying to emphasize the point I've been trying to make for years - if half the money spent on developing PIs had been used to understand IFN better and develop better delivery systems, we'd probably have had the IL28B years ago and there would still be at least one PI for the FDA to scratch their heads over in the coming months.
Oh Merry my dear dear friend you know that i love you, you know that but what do you mean you are going to inject 3x a day? Please, please none of this makes sense............get the PI, do the treatment please my friend stop second guessing this disease you know you cannot do that.
Diet, no drinking, healthy liviing yes but this time go with real science and stop trying to figure it out. The scientists do that! You want to get rid of this once and for all. I want to see you WIN this battle but guessing at things and doing this isn't going to get you there. Oh please.............please........I am seriously getting afraid for you. We've been friends for so many years, let the science dudes prove the science but just get tela or boce when they come out and WIN!!!!!!!!!!!!!!!!!!!!!!!
The Arup test for the TWO Interleukin 28 B (IL28B)-Associated SNP Variants:is 2004680.
BTB
Just posting a link. As more silly research is done it most likely will remain a negative predictor, but who knows. At least it is one that people have any control over. While searching for any other recent discussion on this topic, I was happy to find this comment at the HCV Advocate regarding this study:
Editorial Comment: Although this report contradicts previous information about BMI and response to treatment, this study is limited in its power to be compelling. First, this is a small study, so more data are needed. Second, the research is retrospective, rather than prospective. Data collection from randomized, double-blind, placebo controlled studies carry more weight than data collected when researchers look backward at the data.
We know the drill: Don't overeat, don't drink and don't smoke.