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Latest news on VX-950
Among 74 patients given VX-950 for whom data were available at the end of 12 weeks, 88 percent had undetectable levels of the virus. That compared with 52 percent of those in the group that received only interferon and ribavirin.
[...]
Despite its apparent better potency, 9 percent of patients taking VX-950 dropped out of the latest study due to adverse events, including rash, gastrointestinal disorders and anemia -- compared to only 3 percent taking the standard dual therapy.
http://tinyurl.com/ydkred
[...]
Despite its apparent better potency, 9 percent of patients taking VX-950 dropped out of the latest study due to adverse events, including rash, gastrointestinal disorders and anemia -- compared to only 3 percent taking the standard dual therapy.
http://tinyurl.com/ydkred
Maybe someone can help me, why only 74 people? Is this only group D? All arms have been done the 12 weeks vx for sometime now. I just did shot 20 monday, I go the 19th for my week 20 labs, and I get unblinded the 27th, would be sooner but my study nurse will not be back untill then. APK, any news???
My study had 7 slots open for this study, I know 2 droped out, one because she has no ins and the study will not help with sides,you must go to your pcp, she was having eye and skin problems. I just tx my 4th uti, more bactrin. Pam
New York Woman,
You are so right about the stock price. It has been getting thrashed all week by s.o.b.'s who hoped the drug would fail. That is the nature of the market, those folks are there to make money, we are just the money makers for them.
I follow the stocks for my husband, who is pretty smart about it all, but we are not rich, by any means. He's working his tiny butt off to try and make enuff for two of us to retire on, as I do not have the huevos that you do, I could not continue working. Panic, fatigue, you know, the usual crud.
But I have learned real things about Vertex, it is not a company all about just one drug. MD Anderson Hospital in Houston, which is fairly big league, just came out with very good results on a cancer drug that Vertex is working on. And Vertex got paid $15 mil today for the FACTS about VX950 from a large pharma that it is working with. So things are rolling along for Vertex, rocky as hell this week, but the stock price has nothing to do with the small success of VX. In a long term view, there is good news abounding, for me, for Vertex, for all of us.
You are so right about the stock price. It has been getting thrashed all week by s.o.b.'s who hoped the drug would fail. That is the nature of the market, those folks are there to make money, we are just the money makers for them.
I follow the stocks for my husband, who is pretty smart about it all, but we are not rich, by any means. He's working his tiny butt off to try and make enuff for two of us to retire on, as I do not have the huevos that you do, I could not continue working. Panic, fatigue, you know, the usual crud.
But I have learned real things about Vertex, it is not a company all about just one drug. MD Anderson Hospital in Houston, which is fairly big league, just came out with very good results on a cancer drug that Vertex is working on. And Vertex got paid $15 mil today for the FACTS about VX950 from a large pharma that it is working with. So things are rolling along for Vertex, rocky as hell this week, but the stock price has nothing to do with the small success of VX. In a long term view, there is good news abounding, for me, for Vertex, for all of us.
pam - Got your message, glad to hear you're doing well. Hang in there for the unblinding, we both know you were gettin' the good stuff. I think you're gonna make your SVR in flying colors, so keep the faith. I really think you're well on your way to the promised land!
As far as Vertex only reporting on the results of only 74 VX dosed patients (out of a total of 175 receiving VX950): I think all that means is that the data they're presenting was sampled before all VX dosing patients had completed their 12 full weeks. In other words, this data was sampled sometime in the past (probably a few weeks ago) when only 74 of the VX dosed group (out of the total of 175) had completed their full initial 12 weeks of dosing. So this means that 101 were still not completed with their 12 week cycle before this data was sampled (and subsequently presented in their press release), and so that's why they were left out.
At least I THINK that's what it means!! ;) I agree it's a little ambiguous. I also would like to know if the 9% they mention quit altogether, or if that means they only stopped the VX.
Hope you're doing well. In the meantime keep on keepin' on, I definitely think you're gonna make it!
As far as Vertex only reporting on the results of only 74 VX dosed patients (out of a total of 175 receiving VX950): I think all that means is that the data they're presenting was sampled before all VX dosing patients had completed their 12 full weeks. In other words, this data was sampled sometime in the past (probably a few weeks ago) when only 74 of the VX dosed group (out of the total of 175) had completed their full initial 12 weeks of dosing. So this means that 101 were still not completed with their 12 week cycle before this data was sampled (and subsequently presented in their press release), and so that's why they were left out.
At least I THINK that's what it means!! ;) I agree it's a little ambiguous. I also would like to know if the 9% they mention quit altogether, or if that means they only stopped the VX.
Hope you're doing well. In the meantime keep on keepin' on, I definitely think you're gonna make it!
Oh yeah another thing I forgot to mention is that I don't think Vertex would be including anyone amongst the VX groups that stopped taking the VX early due to sides and/or who may have required IFN and/or riba dose reductions and/or who may have taken a drug that might skew the viral response (i.e. immunosuppressants like prednisone/solumedrol). So this would exclude the data from myself, PDS and even you for example (because of your reduced riba). The 74 they discuss are described as taking VX950 and peg/riba during their 12 weeks, so I think this means they are only reporting what the viral response was for those that maintained full doses of everything all the way through the 12 weeks. This would also make the results look better (without actually lying), which would be good for their stock price too.
But, again they're pretty vague and leave quite a bit to our imaginations. But I'm satisfied that the VX definitely adds to viral response.
But, again they're pretty vague and leave quite a bit to our imaginations. But I'm satisfied that the VX definitely adds to viral response.
hey rev you posted above that you would not want to post any personal info for fear of enemies but the way you been lately you have NO enemies. not what i think matters but your posts have been great and i know you have and will help a lot of people if you continue to share your wealth of knowledge.
PS, i would never share any personal info even if i was the most liked person in a forum. way to dangerous!
PS, i would never share any personal info even if i was the most liked person in a forum. way to dangerous!
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