Losartan (Cozaar) and NF-kB. Help researchers!

[Wilful1]

Someone posted some information on a study done in Spain on how Losartan (Cozaar) and shown some success in help with liver fibrosis, so I read it and it is very interesting.  From that article I searched NF-kB and it got very technical after that.  My understanding is that NF-kB is instrumental in helping to replicate inflammatory cells even in hep c and b to keep it chronic and is also found in cancer cells.  But I really had a difficult time understanding the studies done on this and was hoping someone out there is a biology buff and could explain in a lay person's terms what this means.  I have high blood pressure and chronic migraines and am just finishing hep c tx (48 weeks) but thought this medication may serve several purposes for me:  control the high bp, maybe control the migraines, and help my liver repair itself.  Any takers on this one?
Thanks,
Wilful

[Wilful1]

Thanks for commenting on this post as I do have high blood pressure and haven't been on meds for it yet.  I have an appointment with my GP this morning to address it.  I did call my gastro dr and he was on vacation, but also called my neurologist and he said it might work for migraines.  I've been reading more about this protein NF-kB and it is facinating how it impacts so many things.  Cancer, heart, liver, and other inflammatory conditions, and I am also concerned about how this tx has imacted in my body.  The chemo fog has really impacted my ability to read and remember, so again I kindly thank you for addressing some of the technical aspects of what you have read.

Wilful

[merryBe]

Hi, Wilful, yeah I remember soomething about Derek MAnn from Newcastle finding the first BP med that reversed fibrosis, so this will be great for those with high BP...it will probably be a fight to even get a small dose if one doesn't have high BP...not being a SOC tx.
I haven't followed all this closely since I don't have high BP but if I did have it, I would certainly advocate for yourself with your doc. I mean if one med can solve or help 2 problems it would make infinite sense, and insurance might not raise eyebrows just for a switch in BP meds as docs do that all the time. Although, I would definitly not call the "reason for the change" to the insurances attention if it were my patient, I would just switch them. Otherwise the cost of one med over another may result in a denial.

Sorry I don't understand the biology here, but someone may. Be patient.
One thing I know is that Nf-kb effects not just blood presure but tumor necrosis as well as diebetic oxidative stress, so anything that helps inhibit Nf-kb would be helpful to all of us not just liver patients. A while back I was reading up on alpha lipioc thinking I'd include it in my regime...and then a bunch of hulla-bull-etc. came out about it being not good. SO I know what you mean about the technical stuff, it's enough to make your head spin Linda Blair style. Not only is it technical but then there are the contrarian viewpoints, and how does a layman know the voracity of the claims pro or con.
Now we have to worry, will the cure cause more oxidative stress than what it rid us of, and if so why. Personally I'm torn between whether the rancidity factor is the big culprit with alpha-lip. or whether drug companies are just paying for studies to refute any natural cure!
But in any case it will be interesting to see if anyone can give you a layman's primer on this. It reminds me of the P450 connundrums. Actually it fries my brain just mentioning this stuff again.

mb