Low Neutrophils

[Diana66]

Since I started tx with a base of 1.64 I have been flaoting around the 0.56-0.7-0.88-1.05 for the last 14 weeks

Today all of a sudden I bottomed to 0.3. This is on an already reduced Interferon dose of 135. I am waiting to hear from the doctor now of what the plan is but would this sudden drop be just from the Interferon or is it possible to have other reason as well

2 weeks after the Incivek: Hemoglobin at 10.1, Platelets at 58 so only the Neutrophils are the problem

Any ideas, suggestions?

[flcyclist]

"How long is taking for Neupogen to rebuild?"
It boosted the ANC very quickly for me.  Since I never had a cbc prior to 2 days after the neupogen shot, I'll have to say 2 days, but I'd suspect quicker than that.  Although patients may respond differently, I believe this to be most common response.   I've heard some report that their ANC stayed elevated after one neupogen shot, while mine went through the weekly crash after the interferon injection, so weekly for me.  

I'd suggest to read through the thread that Idyllic posted above for more detail.  I was referred to a Hematologist to monitor the cbc's, so I was fortunate to request these reports prior to each neup injection.  Hope that helps.

[Idyllic]

I would think you would see some type of increase in ANC a few days after the Neupogen. Frequent (routine) CBCs might be necessary in the beginning. Here is a good thread thread that answered a lot of my questions when I started Neupogen (the posts are the same people who posted in this thread)

flcyclist's post is interesting since he was able to have CBCs within days
http://www.medhelp.org/posts/Hepatitis-C/Timing-of-neuprogen/show/1786950

Oh sorry I just noticed you addressed this to Advocate. Hope this is OK
http://www.medhelp.org/posts/Hepatitis-C/Timing-of-neuprogen/show/1786950

[Diana66]

My neutrophils were reduced even before tx. I started with a base of 1.64 (minimum should be 1.9) and that was a good month. Had drops to 0.9 even the few months before tx. Presumably low values were from lymphoma

How long is taking for Neupogen to rebuild
I have been told to hold on doing my Interferon injection last night, we are waiting for an answer from the doc today

[willbb]

You may want to go over this thread if you have some time.(below).

Good luck..

Will


http://www.medhelp.org/posts/Hepatitis-C/Some-clarification-if-someone-knows-or-doctor-has-explained/show/1656098?personal_page_id=1837989

[Advocate1955]

I don't think you need to worry about low level virus causing your Neuts to drop.  After all, your Neuts were fine before you treated your Hep C, right?  To my understanding, and I'm not a doctor, the drop in Neuts is due to the effects of treatment drugs.  Sometimes we just need the Neupogen to help rebuild.  I would suggest asking for Neupogen and trying to rebuild (so you don't get sick or get infections that might compromise finishing treatment).
Advocate1955

[Diana66]

yea, that is what I thought as well but I have done my injection last Thu evening and i had the cbc today (Thu) in the morning. So should have been the highest....

I think they might have Neupogen available, waiting to hear from them later today

Is it any other reason for the neutrophils to drop (eg. low level viral or bacterial infection)?