If you go to "PubMed" or similar and search under "Lindhal" you will come up with a bunch of interesting studies in this vein. One of her earlier studies had to do with the relationship between anemia and serum riba levels. I do not believe it is available online and I had to hunt it down "old school" at a medical library.
Yeah, it was quite a trip for me. The famous 90% Lindahl study came out a week after I started treating and for the next three days I got hold of everything that group wrote and switched doctors to someone who would try something more agressive. The article was so new that I actually read it before the doc.
Problem was I upped my riba from 1200mg/day to 2000mg/day over a five day period, when I should have done it more gradually -- say over a six *week* period. I was under the erroneous impression that if I felt OK at 1400mg/day for a few days then it was OK to go to 1600mg, etc, etc. Of course, later found out that riba builds slowly in the system with around a 2-3 week lag between increased riba dosage and a decrease in hgb. I was in the process of researching how best to send my blood to Sweeden for HPLC testing when WHAM I was in the ER :) Needless to say, my enthusiasm for that protocol waned and I pretty much just tried to stay in the game (at 1200 mg/day) for the duration.
Knowing what I do now, I could probably design a regimen for myself to maximize riba absorption without ending up in the hospital but fortunatly that's purely academic. Riba is stong and potentially dangerous stuff and one should only "monkey" around with it under the supervision of a doctor who understands the consequences and is willing to intervene appropriately. In other words, do what I say, not what I did. LOL.
-- Jim
Just to let you know that the riba really affects everyone differently. I am post transplant so that might make a difference but I started on only 200 riba a day, progressed to 400/day. Never went to a higher dose in 70 weeks. Late UND but I did get there. Also had HBG around 9 the entire tx on procrit once a week. Had one drop to H&H 6/19 and had to be transfused. That stuff is potent. Please don't adjust it without someone knowing is my advise
Urea mMo1/L ref range 3.0-6.5 24th August 2005 6.5 28th July 2005 5.2 7th July 2005 7.4 (H).On combo during this period.
0ff combo 5th July 2006 12.4 27th April 9.0 13 April 7.8.Treatment ceased March 2006 so rising trend as I relapsed.
Creatinine uM01/L ref range60/120 normal except 180 July 2006 111 August 2006 119 Sept,so 'high normal' off combo with blip in July.
For example urea 10.1,creatinine 119. as of 18th September.
I have glimpsed the biopsy report on the screen in the consulting room but dont yet have hard copy.Noted reference to necrosis.
Concerns that if interferon induced future possibility of transplantation (liver) would be obviated by renal inability to secrete immuno-suppressant drugs.
On a more optimistic note I seem to infer that urea and creatinine more normal when on combo than off.
I will have copy of biopsy report later this month after I meet with nephrologist.Your further observations welcome.
i would be interested in the history of your renal problems that lead to the renal biopsy.
History, bloodwork, urine analyses, clinical symptoms, radiology findings,cryo or other immune complexes found?
How did they arrive at the temporary diagnosis "nephritis". How was "kidney dysfunction" defined.
When will you get the results of the renal biopsy?