Aa
No RVR on SOC
Drum roll............HCV RNA iu/mL: 226
Nurse called with week 4 labs and I didn't clear. Kinda bummed, but I will be really bummed if I don't clear at 6 weeks as that will mean I got placebo. It is an official 4 log drop by week 4 though, so I am thankful for that.
And my platelets are a freak show. The are almost normal in the 120s and have been over 100 since I screened!! It is so confusing. My spleen is enlarged, HR had my Fibroscan at 21, I have varicies and my platelets are hanging in on tx. I know they fluctuate, but I am clearly interferon sensitive and yet it is not making my platelets tank. Go figure.
This does make for a weird situation as far as figuring out the placebo thing, though. Stormrider, did you ever get your 4 week labs? Were you clear at 4? If I am clear at 6, I will not know if it was just SOC or I got the Boceprevir.
If I am NOT clear, I feel that it means placebo, right? NYGirl hung at 400 forever on SOC. Even though it would be only two weeks of trial drug, there is only 226 of those suckers to kill. Also, if in placebo arm and you are clear at treatment week 24, I think (I have to look the week up again) you aren't offered the rollover to the real drug.
Another thing is my blood has been drawn about 44 hours after injection on 2 and 4. My week 6 will be next Wednesday, 96 hours post injection. Does that screw things up? Here are my labs to date:
TREATMENT WEEK 0 (Day 1)
HCV RNA iu/mL: 9,920,000
Bilirubin: 0.7
ALT: 44 AST: 41
Creatinine: 0.8
Hemoglobin: 15.75
WBC: 5.36
ANC: 3.7
Neutrophils: 69
Platelets: 137
TREATMENT WEEK 2
HCV RNA iu/mL: 2420
Bilirubin: 1.1
ALT: 21 AST: 30
Creatinine: 0.6
Hemoglobin: 12.2
WBC: 2.95
ANC: 1.67
Neutrophils: 56.7
Platelets: 127
TREATMENT WEEK 4
HCV RNA iu/mL:
Bilirubin: 0.7
ALT: 18 AST: 27
Creatinine: 0.6
Hemoglobin: 10.9
WBC: 1.78
ANC: 1.0
Neutrophils: 56.9
Platelets: 124
Nurse made no comment about anything and didn't ask how I was feeling (which, I realize now, doesn't matter to them after no help through the horror of the first three weeks). I have nurse appointments but do not see the doc until February. I thought a few things seemed a little low but I guess not enough to concern them. Just can't walk for more than 20 paces without having to sit down, but oh well (unless I am having chest pains or am ready to kill myself, there is no reaction). I guess the upside is my body is absorbing the hell out of the riba.
Super smiley sweet and nice nurses though! Plenty of nodding of the heads, "Oh gosh darn it, that's unfortunate, yes, those darn sides, cripes that's too bad, are you drinking enough water, oh, don't drink too much water, hmmm you should be feeling fine by now, because most people don't have many side effects at this center, you know a positive attitude really takes care of many of our patients side effects..." ARRRGGGHHH.
One thing that I don't get is the helper for whites getting pooh-poohed by two doctors I am dealing with. My main doc (big shot transplant guy, hcv expert) said they don't believe it works and don't prescribe it, and the trial doc says it isn't part of the trial. I know that shouldn't be a concern unless ANC would drop quite a bit lower, but I would like to know what the deal is. Wonder if I will have to be near heart attack to get Procrit.
I am due for my 6 month AFP and ultrasound for HCC that is through my main guy, maybe he will go ahead and prescribe whatever I need. I have the damn insurance.
Can you tell I am crabby? Anyone? Anyone? I guess that is enough venting/rambling for now. I will return before the New Year in a better mood.
Foo
Nurse called with week 4 labs and I didn't clear. Kinda bummed, but I will be really bummed if I don't clear at 6 weeks as that will mean I got placebo. It is an official 4 log drop by week 4 though, so I am thankful for that.
And my platelets are a freak show. The are almost normal in the 120s and have been over 100 since I screened!! It is so confusing. My spleen is enlarged, HR had my Fibroscan at 21, I have varicies and my platelets are hanging in on tx. I know they fluctuate, but I am clearly interferon sensitive and yet it is not making my platelets tank. Go figure.
This does make for a weird situation as far as figuring out the placebo thing, though. Stormrider, did you ever get your 4 week labs? Were you clear at 4? If I am clear at 6, I will not know if it was just SOC or I got the Boceprevir.
If I am NOT clear, I feel that it means placebo, right? NYGirl hung at 400 forever on SOC. Even though it would be only two weeks of trial drug, there is only 226 of those suckers to kill. Also, if in placebo arm and you are clear at treatment week 24, I think (I have to look the week up again) you aren't offered the rollover to the real drug.
Another thing is my blood has been drawn about 44 hours after injection on 2 and 4. My week 6 will be next Wednesday, 96 hours post injection. Does that screw things up? Here are my labs to date:
TREATMENT WEEK 0 (Day 1)
HCV RNA iu/mL: 9,920,000
Bilirubin: 0.7
ALT: 44 AST: 41
Creatinine: 0.8
Hemoglobin: 15.75
WBC: 5.36
ANC: 3.7
Neutrophils: 69
Platelets: 137
TREATMENT WEEK 2
HCV RNA iu/mL: 2420
Bilirubin: 1.1
ALT: 21 AST: 30
Creatinine: 0.6
Hemoglobin: 12.2
WBC: 2.95
ANC: 1.67
Neutrophils: 56.7
Platelets: 127
TREATMENT WEEK 4
HCV RNA iu/mL:
Bilirubin: 0.7
ALT: 18 AST: 27
Creatinine: 0.6
Hemoglobin: 10.9
WBC: 1.78
ANC: 1.0
Neutrophils: 56.9
Platelets: 124
Nurse made no comment about anything and didn't ask how I was feeling (which, I realize now, doesn't matter to them after no help through the horror of the first three weeks). I have nurse appointments but do not see the doc until February. I thought a few things seemed a little low but I guess not enough to concern them. Just can't walk for more than 20 paces without having to sit down, but oh well (unless I am having chest pains or am ready to kill myself, there is no reaction). I guess the upside is my body is absorbing the hell out of the riba.
Super smiley sweet and nice nurses though! Plenty of nodding of the heads, "Oh gosh darn it, that's unfortunate, yes, those darn sides, cripes that's too bad, are you drinking enough water, oh, don't drink too much water, hmmm you should be feeling fine by now, because most people don't have many side effects at this center, you know a positive attitude really takes care of many of our patients side effects..." ARRRGGGHHH.
One thing that I don't get is the helper for whites getting pooh-poohed by two doctors I am dealing with. My main doc (big shot transplant guy, hcv expert) said they don't believe it works and don't prescribe it, and the trial doc says it isn't part of the trial. I know that shouldn't be a concern unless ANC would drop quite a bit lower, but I would like to know what the deal is. Wonder if I will have to be near heart attack to get Procrit.
I am due for my 6 month AFP and ultrasound for HCC that is through my main guy, maybe he will go ahead and prescribe whatever I need. I have the damn insurance.
Can you tell I am crabby? Anyone? Anyone? I guess that is enough venting/rambling for now. I will return before the New Year in a better mood.
Foo
but if you clear by week 12 ,dont you just continue on with the SOC drugs if you are in arm 1?
Foo, yes my platelets tank on tx. Last time they got down into the 30 to 40,000 range. Also have problems with my hgb. Its already went down from over 15 to 11.
Rock, yes that is the navie trial study storm posted.... My Hepo told me my week 12 pcr should be back in a week, at which time if i'm on the placebo he will start me right then on the real thing. So your still looking at 35 weeks of boceprevir.
Rock, yes that is the navie trial study storm posted.... My Hepo told me my week 12 pcr should be back in a week, at which time if i'm on the placebo he will start me right then on the real thing. So your still looking at 35 weeks of boceprevir.
I THINK THIS INFO is for the naive trial...because my papers say i have a 4 out of 5 chance of getting the real drugs...not 2/3...
I do have all this info already...but for the life of me...i still dont fully understand it all..i need a "nut shell" version...LOL
It looks like no matter waht arm we are in....we have the option to get the real drugs at certain times in all 3 arms....not too bad
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