Non-Responders and New Medication

[Revalation]

Are non-responders having any success with the new medications used to treat Hep C.
Apparently, there is only a 32% chance or reaching SVR for this group.

[giddyup]

Yup i went to the clinical research doc today. Mere 15%  for cirrotic  1a non responders. Sigh. The did say new drugs show hope as the cocktail approach enlarges but it is unlikely that cirrotic non respomders will be excepted in the first studies, just non responders. Perhaps that 15 will go to 40 with additional drugs so ill just hang in there till these new additions become available in trials. Lots of love to all you special med help people.

[Revalation]

What is on the horizon for null-responders in that you only have one

chance with these kinds of medications.

[SusieS2010]

Also, in cirrhotic patients who were previous null-responders, the rate of SVR drops to less than 15% with triple therapy.

[willbb]

Just to add to what flcyclist has posted.... The other protease(Victrelis) in trial for previous treatment patients showed:
SVR :75% for relapsers and   52% for  partial responders.
Null responders( <2 log drop by wk.12 on a prev. tx) were not included in trial.

Will

[flcyclist]

Overall, the SVR rates in patients with prior relapse, partial response and non-response were 86, 58 and 32% respectively with teleprevir.  Patients who do not achieve a RVR, those with cirrhosis and certain prior non-responders should be treated for 48 weeks.

http://hepatitiscnewdrugs.blogspot.com/2012/01/triple-therapy-for-hcv-geno1-telaprevir.html