Getting off treatment can be hard too because by withdrawing drugs your system is trying to adjust to a new environment. Typically, it takes about a week for hemoglobin levels to adjust and another week before you feel the effect of that. If she was taking other drugs to control symptoms then it complicates things as you can't just go cold turkey at the end of treatment with every drug. This may prolong her recovery, but mental abilities are the last ones to return in my experience and this may take months.
If she's not feeling better with at least some aspects of her health at a month post treatment, then have her contact her doc and get her bloodwork done to see what's going on.
Have patience -- unfortunately, this is normal and many months may pass before your wife begins to recover physically and mentally. Riba stays in the system for 6 months so tell your wife to continue drinking lots of water, eat healthy foods, take light exercise and rest when necessary.
I know it's worrisome because she's been through so much. I too was worried that I would never feel good again after tx. It's been 19 months and I'm finally feeling like my old self. Hopefully it won't take that long for your wife.
Take care,
KF
Sorry, I meant her 48 weeks program and not 48 months.