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Post treatment symptoms of Pegulated Interferon\Raboviron

My wife has succesfully completed 48 weeks of treatment for HepC using the Pegulated Interferon\Raboviron combination.About the secound month of treatment joint pains developed in her hips and elbows.Treatment finished in January 2006 and Blood tests in July indicated no virus detected. She has returned to work in September on a limited basis.Her pain in hands,hips and elbows has been increasing at an alarming rate. She has been in contact with her doctor regularly, who has been very good in doing tests for different arthritis's which turn up non detectable.She will see an athritic specialist in London in November.  To date I have found very little on Post treatment effects\symptoms. My question...does this treatment exaserbate arthirtic symptoms in patients post treatment?
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Avatar universal
Re:  Some will try to claim that these problems cropping up after tx are a 'coincidence', or are due to some sort of rapid aging.

How ridiculous to keep saying this.  The point was that since such symptoms can be seen in the aging process, it must be difficult to definitively link them to the effects of interferon treatment.  But Kalio supplied you with research that supports your suspicions, even though she/he was treated rudely on the other thread.

Why don't you drop the unreasonable bitterness you hold?  It can't be good for your health....
Avatar universal
Yes, many of us on the forum have experienced a range of post-tx problems, including joint pains, fatigue, sun-sensitivity, rashes, autoimmune problems, etc.  I will post a link below, which was kindly included below by Kalio in another thread, which is a large survey on post-tx symptoms.  If you complete the survey (it is very easy and takes little time)you will then be able to view the results of the survey, and a large number of individual comments by the participants describing their own particular post-tx experiences.  Here is the link:

http://www.hepcuk.info/data/usercontentroot/home/treatments/Post%20Treatment%20Survey.asp  

Disturbing symptoms that emerge after completing tx are a 'hot' subject on this forum currently.  Some will try to claim that these problems cropping up after tx are a 'coincidence', or are due to some sort of rapid aging.  Of course those people do not have these symptoms!  I think to all who have experienced these very disturbing symptoms on the heels of therapy, it is very clear and obvious that there is a connection to therapy.  The pattern seems to run through at least 35% of the overall post-tx group who took the survey.  

I would like to see even larger surveys done, across the entire treatment population.  I will bet the results are essentially the same.

DoubleDose
1 Comments
Please repost site I got an ad over half the address. Thanks I'm 10+ years post treatment peg interferon/ribivon and I went to bed for 6 months of 48 month treatment.  I'm still in bed. It's been a nightmare. I have no quality of life and now my depression out there I can't even go outside anymore. I wasn't warned of any lasting effects  if I had just known. People are sick this stuff is awful. I barely had a viral load and a perfect liver I wish I'd been given a choice of natural therapy but I wasn't given a choice I trusted my dr I knew my dr. But I cant find a dr who can treat all 13 of my chronic illnesses. Please add address.
Avatar universal
I had hip and leg pain pre and post tx. I'm still on pain meds. You might want to ask her doctor about Cryoglobulinemia a hepc related blood disease which can cause arthritic type pain. Sorry about the pain ,I feel for her.
Avatar universal
What is needed is the application of scientific method to the HYPOTHESIS that tx causes these conditions. Evidence based medicine is based(since the mid 1800's at least )on scientific method not patient's symptoms. ALL the people who have these symptoms form the basis for the hypothesis, the FIRST STEP in discovering IF there is a connection. It's like you just ignore how we arrive at "facts" in medicine and say " well I have these symptoms and so do 10 of my friends so I will ignore all the other possible variables because I took these drugs! It must be them!" If people here even mention the various variables to you you flip out and act as if it is outrageous we would mention the obvious, aging, depression, underlying or previous illnesses, unknown variables, the list goes on.

The survey helps to gather the evidence so the process can then be undertaken to try to establish the MEDICAL CAUSAL LINK.


This is basic medicine! I get frustrated that you try to personalize this, or claim facts where they don't exist. I didn't invent evidence based medicine, I thought scientific method was something we all learned in like the 8th grade. Go be mad at Pasteur or someone who helped to bring medicine AWAY from this type of thinking! People used to think the devil made them sick too, I guess since a lot of people thought that, it must be true! sheesh.

What has been proven, by scientific method, is that Interferon alpha 2b causes a reduction in fibrosis and lowers the risk of heptocellular cancer for a substantial number of patients to name just a few of the HOST of BENEFITS it has long term on patients. And that's a FACT.
Avatar universal
By the way, you can't just make up statistics like you do "35% have these problems" was what you said I believe, what hat did you pull those stats out of?


This type of thing is why doctors steer their patients AWAY from the net because it creates unfounded and unnecessary fear in newly diagnosed patients and a lot of the "information" is not correct or like these statistics, completely made up. It decreases our credibility.



Avatar universal
Thought I would post a link to a study:

Hepatology July 2004 Vol 40 Issue 1

However, the excellent treatment success may be accompanied by IFN-related side effects in some patients.

http://www.natap.org/2004/HCV/080404_06.htm
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