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Prolems with retina from triple tx
I had my first follow up appt. with my opthamologist since starting triple tx and he found that I have light sensitivity/blind spot in my right eye. I'm seeing a retinal specialist on Monday... anybody else have problems with their retina from tx? I've read that it's possible but there was a low chance... just wondering if anyone on here actually had that problem and any other relevant info... thanks!
thanks for the information! my opthamologist mentioned he was concerned about possible retinal hemorrhage... on Monday they're going to put a die in my eye to see if this is the case... keeping my fingers crossed that my eye is fine....
My hepatologist wanted a retina exam before I started treating. The retina specialist okayed me for treatment and scheduled another exam for 2 months after I started treatment to check to see if my retina is handling the interferon. I think problems are rare, but if you do have problems you need to get them taken care of aASAP. This article is pretty good
http://hcvets.com/data/hcv_liver/eyes.htm
Cotton-wool spots were found in 31 patients and retinal hemorrhage in nine patients during treatment (24% of patients). These lesions remained asymptomatic and disappeared in all patients. A previous history of arterial hypertension (RR 4.60, 95% CI 1.95-10.85), age above 45 years (RR 2.80, 95% CI 1.36-5.85), and use of pegylated alpha-interferon (RR 2.75, 95% CI 1.41-5.38) were significantly associated with retinopathy. Neurovisual impairment was present in 31 patients (20%) before treatment and in 74 patients (47%) during treatment.
In studies including a significant number of diabetic patients [5,7] diabetes mellitus has also been associated with retinopathy. Furthermore, improvement of retinopathy is delayed in hypertensive and diabetic patients after ending treatment [7]. This relationship emphasizes that IFN-induced retinopathy can result from physiopathological mechanisms in common with other retinopathies related to microvascular abnormalities.
Conclusions: In conclusion, this study showed that signs of retinopathy and neurovisual impairment were common in patients receiving alpha-interferon therapy but were rarely symptomatic. It suggests that alpha-interferon may usually be continued in asymptomatic patients as long as there is careful fundoscopic examination.
http://hcvets.com/data/hcv_liver/eyes.htm
Cotton-wool spots were found in 31 patients and retinal hemorrhage in nine patients during treatment (24% of patients). These lesions remained asymptomatic and disappeared in all patients. A previous history of arterial hypertension (RR 4.60, 95% CI 1.95-10.85), age above 45 years (RR 2.80, 95% CI 1.36-5.85), and use of pegylated alpha-interferon (RR 2.75, 95% CI 1.41-5.38) were significantly associated with retinopathy. Neurovisual impairment was present in 31 patients (20%) before treatment and in 74 patients (47%) during treatment.
In studies including a significant number of diabetic patients [5,7] diabetes mellitus has also been associated with retinopathy. Furthermore, improvement of retinopathy is delayed in hypertensive and diabetic patients after ending treatment [7]. This relationship emphasizes that IFN-induced retinopathy can result from physiopathological mechanisms in common with other retinopathies related to microvascular abnormalities.
Conclusions: In conclusion, this study showed that signs of retinopathy and neurovisual impairment were common in patients receiving alpha-interferon therapy but were rarely symptomatic. It suggests that alpha-interferon may usually be continued in asymptomatic patients as long as there is careful fundoscopic examination.
I don't have experience with this but I am giving you a bump so that it won't be missed. Best wishes.
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