Aa
Protease Inhibitor
Anyone know anything about this stuff?
I can deal with that side, it's the others not sure I will be able to deal with. I can't afford to be worst than I am now and work. Unfortunately job first. Can't work, nothing else is possible. Not sure what I will do yet. I have Geno 1B. If I decide to do this they will get one shot at it. I plan to let the dr know that at the followup of the biopsy. IF it is even an option. Alot of unknowns and getting about sick of it all, years of getting feed bull*&^* when my chances would have been better sooner, maybe. Well enough, I don't know why I keep coming back to these sites. They are more depressing than helpful. Not to say, I don't appreciate the straight anwers. It is just depressing and offers no hope. Good Luck to you and thank you for the reply....D
Hi Dora,
I'm a GT-1a with Stage 2 slight portal bridging. Yes unfortunately, the binder they use is an natural oil base, so it acts like a laxative. But like I said you have to deal with sx from the combo too...:( Hope that helps!
Cheers!
Tony
I'm a GT-1a with Stage 2 slight portal bridging. Yes unfortunately, the binder they use is an natural oil base, so it acts like a laxative. But like I said you have to deal with sx from the combo too...:( Hope that helps!
Cheers!
Tony
Thank you all, So, running off is the only side effect to the inhibitors? What geno type are you? If I do the tx at all, they only get one chance to get it right. So, I am trying to find info. I will check out the sites you gave. Thanks so much, Dora
Hi Dora,
I'm starting week 15 in the VX-950-107 trial, it seems to be working for me. I've gone through several clinical trials, none are fun, but I've been non-detect from week 2. I started at a VL of almost 5 million. went to 45 iu/ml first week then <25 iu/ml at week 2. At the detection level they (vertex) are using anything less than 25 is considered non-detect. The worst is it makes you VERY regular, if you catch my drift. Then all the wonderful sx with the peg/riba. Check out the Vertex website, the Univ of Cincinnati has a lot of info too. Check out Kenneth Sherman, MD, PhD, he's my physician.
Good luck!
Tony
I'm starting week 15 in the VX-950-107 trial, it seems to be working for me. I've gone through several clinical trials, none are fun, but I've been non-detect from week 2. I started at a VL of almost 5 million. went to 45 iu/ml first week then <25 iu/ml at week 2. At the detection level they (vertex) are using anything less than 25 is considered non-detect. The worst is it makes you VERY regular, if you catch my drift. Then all the wonderful sx with the peg/riba. Check out the Vertex website, the Univ of Cincinnati has a lot of info too. Check out Kenneth Sherman, MD, PhD, he's my physician.
Good luck!
Tony
Dora,
Protease inhibitors are one of the new types of drug therapy's being developed and tested. The 2 newest major types of drugs being tested are protease and polymerase inhibitors. They are drugs that effect the virus replication process. As of now pegylated interferon and ribaviran are the only FDA approved methods of treating hep c. The others are in in trials but show a lot of promise and some have had very good results, some have been scraped because of problems. They are still a few years from becoming approved if they pan out and most likely will be used in combination with peg and riba. VX-950 or telaprevir as it is called is the farthest along and is preparing to conduct the most extensive trial so far. I hope this information helps.
Protease inhibitors are one of the new types of drug therapy's being developed and tested. The 2 newest major types of drugs being tested are protease and polymerase inhibitors. They are drugs that effect the virus replication process. As of now pegylated interferon and ribaviran are the only FDA approved methods of treating hep c. The others are in in trials but show a lot of promise and some have had very good results, some have been scraped because of problems. They are still a few years from becoming approved if they pan out and most likely will be used in combination with peg and riba. VX-950 or telaprevir as it is called is the farthest along and is preparing to conduct the most extensive trial so far. I hope this information helps.
You'll find a search option at the top of the page. Search "protease inhibitor" and you'll find a lot of information here. Yes, a lot of people here do know about PIs, as we call them occasionally, and there is quite a bit of information already covered. So do a little research first and see if you still have questions. Mike
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