SOCS3 Gene: Insulin Resistance, IFN resistance

[MKAndrew]

For six years, I believed there was a single-source connection between interferon resistance and interferon resistance.  It is, as I suspected, a gene.  The gene is SOCS3 - Suppressor Of Cytokine Signaling-3.  The discovery of this gene also sheds some light on why prior nonresponders have more trouble acheiving SVR.

1. SOCS-3 is elevated by HCV's core protein.

2. SOCS-3 elevation causes interferon resistance.

3. SOCS-3 elevation causes insulin resistance in the liver.

4. SOCS-3 depletion reduces liver insulin resistance, but causes systemic insulin resistance.

5. SOCS-3 is further elevated in people who have treated unsuccessfully.

These findings suggest a new and viable target for therapy.  

[jmjm530]

If that is her position, then I also agree with her.

But unless I'm reading things wrong, that has been MY position, not hers,  but maybe I'm reading things wrong.

But once again, my opinion is that in the majority of cases you try weight loss and lifestyle changes first, then try something like Metformin if that doesn't work. And yes, where IR presents itself and there isn't a weight problem, it's not just a matter of losing weight.

-- Jim

[mikesimon]

I think CO would advise obese patients to try and lose weight. Perhaps I am being presumptuous but my impression is that she believes that Metformin can also be a significant aid in reducing IR in patients who don't achieve the goal through weight loss alone and for those patients who are IR and don't have a weight problem. If that is her position I agree with her and if it isn't I still agree with the position.
Mike

[jmjm530]

From memory, Agaston states that a low-carb diet like South Beach can bring IR and metabolic syndrome under control, therefore diet should be a first-line treatment.

CO, But they can "be enough" in some cases and that's why they should be (and are recommended) as a first-line treatment IR in many cases. If your personal opinion is that people aren't motivated enough to do the hard work, that's another story. And I'm still not clear on your position -- would you ask your IR patients to try and lose weight and make lifestyle changes before administering a drug like Metaformin -- do you even give them a choice -- or do you just skip that step and put them right on Metaformin?

[CoWriter]

"As for losing weight, I doubt anyone would diagree in princple.
But as the South Beach Diet indicates being overweight can be caused by IR.
From memory doesnt Agatston state that being overweight is a direct result of a high carb diet. Leptin is also getting the blame in similar diets ie rosedale. All gets a bit circular i know. Being over weight leads to IR. IR leads to weight gain."


Thank YOU!

Of course I'm not saying lifestyle changes aren't important.  I'm just saying they're not enough.  

Co

[CockSparrow]

Just to make it clear i believe that we should try and resolve IR before we start Tx.
Using whatever means we can.
I dont like the way some of these studies similstart Insulin sensitising drugs with the first shot of IFN. Seeing as IFN can induce IR yet at the same time also resolve it.

CS

[CockSparrow]

Say one thing about CoWriter, She is passionate.

As for losing weight, I doubt anyone would diagree in princple.
But as the South Beach Diet indicates being overweight can be caused by IR.
From memory doesnt Agatston state that being overweight is a direct result of a high carb diet. Leptin is also getting the blame in similar diets ie rosedale. All gets a bit circular i know. Being over weight leads to IR. IR leads to weight gain.

In otherwords I guess Co is saying if you resolve IR then the weight loss will look after itself as it did in Meki's case. Which is also what Agatston is saying.

No simple answers really
CS

PS Meki, I'll try and answer you Posts Questions Tonite. My Tonite that is.