SOCS3 Gene: Insulin Resistance, IFN resistance

[MKAndrew]

For six years, I believed there was a single-source connection between interferon resistance and interferon resistance.  It is, as I suspected, a gene.  The gene is SOCS3 - Suppressor Of Cytokine Signaling-3.  The discovery of this gene also sheds some light on why prior nonresponders have more trouble acheiving SVR.

1. SOCS-3 is elevated by HCV's core protein.

2. SOCS-3 elevation causes interferon resistance.

3. SOCS-3 elevation causes insulin resistance in the liver.

4. SOCS-3 depletion reduces liver insulin resistance, but causes systemic insulin resistance.

5. SOCS-3 is further elevated in people who have treated unsuccessfully.

These findings suggest a new and viable target for therapy.  

[jmjm530]

CS: IR has been known as a negative for quite a while, but there have been no studies that show that improving IR improves svr.
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As I mentioned in the other thread, many liver specialists having been asking patients to lose weight for some time prior to treatment -- so even without specific studies they have been connecting the dots which seems quite logical. BTW what is your position on using first-line measures like diet, exercise, stop smoking, etc, before taking on another drug like Metaformin?

[comeagain]

Did you here that your a smoker aint you me my self stopped 17 years ago started when I was 11 though so been smokoing quite a lot.

[CockSparrow]

Yes there have been studies done. And yes it is associated with non response.
I suspect almost everyone who has a null response is Insulin Restistant
I am, Miles is and so in Bandman to give some examples.

IR is the pre cursor to diabetes. Not everyone who is insulin resistant becomes diabetic.

IR has been known as a negative for quite a while, but there have been no studies that show that improving IR improves svr. Some are starting to come out now that suggest it will.
There have been studies that show reducing weight lowers IR and thus increases svr

CS

[bajawoman]

I am reading also that smoking is also a factor insulin resistance that is my next to do on my list is to quit smoking as it may also be a factor for me   sorry to ruin your candyfest

[comeagain]

dont say that i´m just sitting here crunching candy reading this !!!

[bajawoman]

I am curious have any studies been done if IR is a leading factor for Non Response to interferon treatment  of all the Non Responders How many are Insulin Resistant? From what I am reading seems Many? I would think Top Heptologists have computer records of their patients  
  Why after all these years of the Interferon treatment  is this only now coming to light??
Diabetics with Chronic HCV  is that different than insulin resistant?  Or are Diabetic conditions the same as Pre Diabetic and do people with Diabetes on tx do they SVR what is their treatment  I do not understand all the technical data much as I am knew to all this but Diabetes is a real factor where I live very high rates due I would think in major part to sugar intake