SVR rates confusion

[wyntre9]

Let me say up front I'm confused!

I thought I understood about SVR rates but after reading forum the past few days it occurs to me that I may be interpreting everything a** backwards.

Clarification, PLEEZE!

I'm 1A, not UND by week 12, Und around week 16, currently on 72 week TX.

I thought that 1A's who reached UND by week 12 had at least a 50% chance of SVR by doing 48 week SOC.

I also thought that slow responders (ie; those who reach UND between weeks 12 and 24) had an SVR rate of only 29%.

Therefore, my understanding was that slow responders who extend to 72 weeks TX increase their chances of SVR .....  but to WHAT?

I mean, do the studies say 1A's who extend to 72 weeks have a 50% SVR rate?  Is it 70%?  29%?

Does anyone know?

Wyntre

[Bill1954]

Wyntre;

Our posts are crossing; you might have misinterpreted this data that suggests:
~~~~~~~~~~~
“…Among the Week 4 HCV RNA undetectable patients, SVR rates were 79% in the arm treated for 24 weeks (i.e., genotype 2 or 3) and 64% in the arm treated for 48 weeks (i.e., genotype 1)…”
~~~~~~~~~~
Unfortunately, (according to this study, anyway) once a GT-1 patient does *not* achieve UND status by week 4, they start to breath different air. Increasing ones statistical odds from 28% to 44% is enough motivation for me. By the way, I was undetectable to <5 IU/mL by week 8 this treatment… I’m currently extending based on a Hx of prior relapse, as well as my ability to tolerate meds.

I’m doing well, thanks for asking. I’ve got classes 4 days a week right now at the local community college, so I’m staying busy in that department. I do seem to feel apathetic in terms of physical exertion; no running or even walking lately. I mentioned above that I kind of fell in a little hole during the mid-thirties- back on track since week 40, though. I wish you the same, gal.

Take care,

Bill

[wyntre9]

I just read through both links (thank you very much) and realized my mathematical dyslexia combined with regular dyslexia must have somehow translated THIS:

"18 Months Therapy (Pegasys+Ribavirin): study found relapse rate reduced by 70%; viral response rate in genotype 1 increased by 50%"

into MY fantasy cruising on De Nile wish that 72 weeks = 70% SVR whereas 48 weeks = 50% SVR.

Doya think I might have a future in advertising?

wyn

[FlGuy]

...and translated from the original Spanish, I guess.

[Bill1954]

You posted above:

…” Therefore, my understanding was that slow responders who extend to 72 weeks TX increase their chances of SVR .....  but to WHAT?..”

“WHAT” = 44%, according to the interpretation by Liz Highleyman of Sanchez-Tapias.

(At least that’s my interpretation of L. Highleyman’s interpretation of Sanchez-Tapias’s interpretation, Lol!)

[wyntre9]

Thanks, Bill.

What's a sense of humour?  *LOL*

These are exactly the stats I was looking for although they're NOT nearly as encouraging as I'd deluded myself into thinking.

Only 44% get SVR after 72 weeks?

Jeeezzzz . . . And I thought it was 72% after 44 weeks.  (just kidding. I'm mathematically dyslexic)

No, seriously, I did think the SVR rates WERE closer to 70% with extended TX.

I was right.

I was wrong again.  :(

How are you holding up now?  I seem to be going through the 35-40 week TX Blues.

wyn

[wyntre9]

Yeah, I've seen this but it doesn't say anything about percentages.

Thanks anyway.

wyn