SVR rates confusion

[wyntre9]

Let me say up front I'm confused!

I thought I understood about SVR rates but after reading forum the past few days it occurs to me that I may be interpreting everything a** backwards.

Clarification, PLEEZE!

I'm 1A, not UND by week 12, Und around week 16, currently on 72 week TX.

I thought that 1A's who reached UND by week 12 had at least a 50% chance of SVR by doing 48 week SOC.

I also thought that slow responders (ie; those who reach UND between weeks 12 and 24) had an SVR rate of only 29%.

Therefore, my understanding was that slow responders who extend to 72 weeks TX increase their chances of SVR .....  but to WHAT?

I mean, do the studies say 1A's who extend to 72 weeks have a 50% SVR rate?  Is it 70%?  29%?

Does anyone know?

Wyntre

[Bill1954]

Hi Wyntre;

Here is an overview by Liz Highleyman from the J M Sanchez-Tapias data (I believe it’s from the Teravic 4 study, actually).

http://www.hivandhepatitis.com/hep_c/news/2006/082906_a.html

An excerpt from the study: …”Looking only at the genotype 1 patients with detectable HCV RNA at Week 4, 44% of those treated for 72 weeks achieved SVR, compared with 28% of those treated for 48 weeks (P = 0.003)…”

You’ll need to browse through the article, but I think this is the pertinent data you’re looking for (one source at least).

For reference, here is the Sanchez study itself:

http://www.natap.org/2004/EASL/easl_06.htm

And more info from Berg:  

http://tinyurl.com/2bjymn

I hope you’re feeling a little better; I had some treatment issues in weeks 35 to 40 that seriously taxed my sense of humor, but now at week 51, life’s pleasant again. Hopefully you were just going through a phase.

Take care,

Bill

[orphanedhawk]

Confunsion, another word for tx??

I hope this link helps.   Take care.        OH

http://www.hivandhepatitis.com/2007icr/easl/docs/042407_a.html

Selected Patients with Genotype 1 HCV May Attain SVR by Extending Treatment Duration to 72 Weeks