Aa
The best treatment
Which is the best treatment for geno 3a
I am humbled, and thank you for your kid words. There were those, like I, that emboldened me with courage to seek the treatment and get it over with...
I hope treatment is going well and the side effects aren't hitting you too hard.
And honestly, even if that treatment doesn't work (Which I am willing to bet A LOT that it will--given what you have told me about yourself) the treatments and cure rates are ALWAYS getting better...
I am interested in how everything is going. Shoot me a personal message if you would like!
TAKE CARE!
I hope treatment is going well and the side effects aren't hitting you too hard.
And honestly, even if that treatment doesn't work (Which I am willing to bet A LOT that it will--given what you have told me about yourself) the treatments and cure rates are ALWAYS getting better...
I am interested in how everything is going. Shoot me a personal message if you would like!
TAKE CARE!
want to try for svr for the fourth time. i would like to know if the further holds a sofosbuvir and dactasvir combo.
Yes ahavs,
I have started treatment, thanks to you. You took out the fear of Peg-Riba treatment by sharing your experience. I started on 31st December.
Will have my 4 week test shortly. Hope to be as lucky as you were :)
I have started treatment, thanks to you. You took out the fear of Peg-Riba treatment by sharing your experience. I started on 31st December.
Will have my 4 week test shortly. Hope to be as lucky as you were :)
"I have had the virus a long time 29 years.......
He also said it would probably Bly be another 28 years before my hep c starts to bother me..."
If I were in your place I would:
Get a different doctor.
Get an IL28B genetic test and do Peg/riba tx. (I'm not a huge fan of clinical trials.)
Good luck.
He also said it would probably Bly be another 28 years before my hep c starts to bother me..."
If I were in your place I would:
Get a different doctor.
Get an IL28B genetic test and do Peg/riba tx. (I'm not a huge fan of clinical trials.)
Good luck.
sorry forgot to add that I am on treatment with per interferon and ribavarin.
I agree with ahavs.
If you have an opportunity to go for Sovaldi, go for it.
If Sovaldi is unlikely to be available to you in the next few years, ypu can go for peg-interferon and ribavarin.
I am into week 4 of treatment for type 3 and had minimal side effects so far.
But then again side effects vary from person to person.
If you have an opportunity to go for Sovaldi, go for it.
If Sovaldi is unlikely to be available to you in the next few years, ypu can go for peg-interferon and ribavarin.
I am into week 4 of treatment for type 3 and had minimal side effects so far.
But then again side effects vary from person to person.
There are no absolutes with this virus and how people's bodies react. I had no fatty liver and basically no damage from having the virus. I am also a Genotype 3a.
Do you know what your viral load is? If it is on the low end, I just say go ahead and do the Riba and Interferon. I know there will be people that will disagree with me. If your overall health is pretty good going into treatment, you shouldn't have too much trouble with the interferon. You will read a lot of horror stories on here about the riba/intraf combo, but there are thousands of other people that seek treatment and just decide not to come on forums such as these to tell their stories. I have met many others that had Hep C and went through the treatment, and it was 50/50. Some of the older patients that were in poor health going into treatment had some trouble because the meds seem to aggravate any other pre-existing conditions. And there were many others that only suffered some minor fatigue, worked a full time job, had kids etc. I worked and lifted weights 4 days a week still.
All I can say is, from my experience, I am happy the virus is gone and it's a huge load off of my shoulders. I was horrified to treat, and I really could have waited, but I am glad I chose to treat.
Do you know what your viral load is? If it is on the low end, I just say go ahead and do the Riba and Interferon. I know there will be people that will disagree with me. If your overall health is pretty good going into treatment, you shouldn't have too much trouble with the interferon. You will read a lot of horror stories on here about the riba/intraf combo, but there are thousands of other people that seek treatment and just decide not to come on forums such as these to tell their stories. I have met many others that had Hep C and went through the treatment, and it was 50/50. Some of the older patients that were in poor health going into treatment had some trouble because the meds seem to aggravate any other pre-existing conditions. And there were many others that only suffered some minor fatigue, worked a full time job, had kids etc. I worked and lifted weights 4 days a week still.
All I can say is, from my experience, I am happy the virus is gone and it's a huge load off of my shoulders. I was horrified to treat, and I really could have waited, but I am glad I chose to treat.
Thanks for your comment, I have just seen great news for sofobusvur and RIBA taken for 24 weeks with a 85 percent chance of a cure.
I have just seen an updated gilead sciences phase three. Trial of sofobusvur with ribavarin for 24 weeks effacy 85 percent for geno 3s, so we have just as much hope as geno 1.
Sorry you have gone through so much, I take it you are going through their compassionate care program? I was just reading about them programs for people in dire need of care post TP... but this combo will still be awhile for the general public.
I'm thinking there was a press release not to long ago and things looked very good for genotype 3 with this combo... Your another example of why people need to rid themselves if at all possible, you have had to go through way to much... Best to you
I'm thinking there was a press release not to long ago and things looked very good for genotype 3 with this combo... Your another example of why people need to rid themselves if at all possible, you have had to go through way to much... Best to you
I am Geno 3 for 30 + years until detected 2010 @ that time was terminal chronic cirrhosis stage..
Found and made team @ Mayo Phoenix, AZ. and was transplanted OCT 2 2012. 6 mouths after transplant went into severe rejection due to virus that was to be next up for treatment but entered the catch 22 syndrome with treatment and could not go forward. Lobbied Gilhead 4 months later because could not get counts to go normal because of combination of immunosuppression and off chart virus load. GL-7977 was released as study case to me in late stage study but was given up after 3 appeals. 2 week in, all counts were normal and virus was undetectable. I keep hoping this works like the doc says it will!
Found and made team @ Mayo Phoenix, AZ. and was transplanted OCT 2 2012. 6 mouths after transplant went into severe rejection due to virus that was to be next up for treatment but entered the catch 22 syndrome with treatment and could not go forward. Lobbied Gilhead 4 months later because could not get counts to go normal because of combination of immunosuppression and off chart virus load. GL-7977 was released as study case to me in late stage study but was given up after 3 appeals. 2 week in, all counts were normal and virus was undetectable. I keep hoping this works like the doc says it will!
"SOV GL-7977 is almost here. Possible next month!!"
That's not what is about to be approved for any genotype as far as I know.
That's not what is about to be approved for any genotype as far as I know.
Hang Tough
SOV GL-7977 is almost here. Possible next month!!
2 weeks in and gone, 8 weeks now and 16 to go.
So So side effects and Kicks A!#
See you on the other side.
SOV GL-7977 is almost here. Possible next month!!
2 weeks in and gone, 8 weeks now and 16 to go.
So So side effects and Kicks A!#
See you on the other side.
Your doctor is assuming a lot, so he thinks fatty liver is nothing to be concerned about?
Besides the results was posted by pooh, so once again not sure where he gets his from.......... Best to you
Besides the results was posted by pooh, so once again not sure where he gets his from.......... Best to you
Hi I have done research on geno 3a. Apparently we get fatty livers and we are the harder to treat according to the hepatitis c trust. But, I have a different answer from my hepatologist who sets up hepatology liver clinics in the uk. He told me geno 3a is the one you want and even with the new drugs I have an eighty five percent chance of success. He also said it would probably Bly be another 28 years before my hep c starts to bother me. Also that if it was hIm he would wait for the newer drugs because of the nasty side effects of interferon and RIBA. Anyway I went home and couldn't forget that I had the virus so I decided to opt for treatment now. So he sent me to another hospital which he set up because the hospital where I am hasn't the funding yet, where I saw a young hepatologist newly qualified and she said if it was her she wouldn't wait. As you don't know when the virus will change. So all very confusing but I am going tomorrow to talk about a drugs trial of rimantidine, interferon and RIBA. I am going with an open mind so we will see and I will have another chance to find out more about the treatment.
Hi, I have had the virus a long time 29 years, no damage so far but I just want the best treatment options with the best cure rate. I have seen two hepatologist and they have given me different answers. One said he would wait for the newer drugs and I have an 85percent chance of success. He also said geno 3a is the best one to have. He has been a hepatologist for the last 20 years and moves around the uk setting up hepatology clinics. Then when I said I wanted to treat he sent me to another hospital because the one near me isn't set up yet as he is waiting for the funding, then the next hepatologist who is newly trained said personally she wouldn't wait and get on with it as she has seen people with end stage liver disease!
And to add to the valuable information that Can-do posted, this excerpt is from the same presentation at Clinical Care Options. Here is what Dr. Fred Poodad said:
"Emerging Treatment Options for Genotype 3 HCV"
Fred Poordad, MD:
The interferon-free combination of the nucleoside analogue sofosbuvir with ribavirin has shown promise in the treatment of genotypes 2 and 3 HCV, and at the time of writing has been submitted for approval for these genotypes.
The phase III Fission trial was a randomized, open-label, active-control, noninferiority study comparing 12 weeks of sofosbuvir plus ribavirin with 24 weeks of peginterferon/ribavirin in treatment-naive patients with genotype 2 or 3 HCV infection. The overall SVR rates were 67% for both sofosbuvir plus ribavirin and peginterferon/ribavirin.[5] Subanalysis based on HCV genotype found that patients with genotype 2 infection had a 97% SVR rate with sofosbuvir plus ribavirin compared with 78% SVR rate with peginterferon/ribavirin. However, the sofosbuvir plus ribavirin regimen for patients infected with genotype 3 HCV achieved an SVR of 56% vs a 63% SVR rate with peginterferon/ribavirin. These results indicate the noninferiority endpoint was met, but for genotype 3 HCV infection, the data are clearly not as satisfying as hoped.
The blinded, active-controlled phase III FUSION study explored treatment with 12 weeks of sofosbuvir plus ribavirin, followed by 4 weeks of matching placebo, or 16 weeks of sofosbuvir plus ribavirin in treatment-experienced patients with genotype 2 or 3 HCV infection. After 12 weeks of treatment in patients with genotype 3 HCV infection, the SVR rate was only 30%.[6] However, the additional 4 weeks of treatment doubled the SVR rate to 62%."
"Emerging Treatment Options for Genotype 3 HCV"
Fred Poordad, MD:
The interferon-free combination of the nucleoside analogue sofosbuvir with ribavirin has shown promise in the treatment of genotypes 2 and 3 HCV, and at the time of writing has been submitted for approval for these genotypes.
The phase III Fission trial was a randomized, open-label, active-control, noninferiority study comparing 12 weeks of sofosbuvir plus ribavirin with 24 weeks of peginterferon/ribavirin in treatment-naive patients with genotype 2 or 3 HCV infection. The overall SVR rates were 67% for both sofosbuvir plus ribavirin and peginterferon/ribavirin.[5] Subanalysis based on HCV genotype found that patients with genotype 2 infection had a 97% SVR rate with sofosbuvir plus ribavirin compared with 78% SVR rate with peginterferon/ribavirin. However, the sofosbuvir plus ribavirin regimen for patients infected with genotype 3 HCV achieved an SVR of 56% vs a 63% SVR rate with peginterferon/ribavirin. These results indicate the noninferiority endpoint was met, but for genotype 3 HCV infection, the data are clearly not as satisfying as hoped.
The blinded, active-controlled phase III FUSION study explored treatment with 12 weeks of sofosbuvir plus ribavirin, followed by 4 weeks of matching placebo, or 16 weeks of sofosbuvir plus ribavirin in treatment-experienced patients with genotype 2 or 3 HCV infection. After 12 weeks of treatment in patients with genotype 3 HCV infection, the SVR rate was only 30%.[6] However, the additional 4 weeks of treatment doubled the SVR rate to 62%."
There seems to either be some confusion or people are just not taking the time to do their research when it comes to genotype 3 and these meds that are about to be approved. It's as clear as can be the success rate is not all that great, and because of that alone insurance might not go along with this treatment. This is as current as one can get, people please quit guessing and research.
Paul Y. Kwo, MD:
In addition, disease severity is an important consideration in choosing whether to treat patients with genotype 3 HCV infection or wait for later therapies. Decisions will also be influenced by how payers approve the use of these new agents. Some payers may only approve peginterferon/ribavirin initially, because it will be less expensive, before allowing providers to move on to newer options for genotype 3 HCV infections, given that these newer regimens have not yet been demonstrated to be more efficacious, though they may be shorter and better tolerated.
http://www.clinicaloptions.com/hepatitis/Annual%20Updates/2013%20Annual%20Update/Modules/Advanced%20HCV%20Treatment.aspx
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With all that said there is drugs that are still in trials but are not the ones about to be approved that so far seem to have better results, keep in mind you liver condition and your insurance plays a big part on when and just what drugs they might cover........Good luck
Paul Y. Kwo, MD:
In addition, disease severity is an important consideration in choosing whether to treat patients with genotype 3 HCV infection or wait for later therapies. Decisions will also be influenced by how payers approve the use of these new agents. Some payers may only approve peginterferon/ribavirin initially, because it will be less expensive, before allowing providers to move on to newer options for genotype 3 HCV infections, given that these newer regimens have not yet been demonstrated to be more efficacious, though they may be shorter and better tolerated.
http://www.clinicaloptions.com/hepatitis/Annual%20Updates/2013%20Annual%20Update/Modules/Advanced%20HCV%20Treatment.aspx
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With all that said there is drugs that are still in trials but are not the ones about to be approved that so far seem to have better results, keep in mind you liver condition and your insurance plays a big part on when and just what drugs they might cover........Good luck
Hello,
There is a lot to take into consideration with this question. The new interferon free treatments are just around the corner, so if you haven't had the virus long or don't have much liver damage, you may want to speak with your doctor and consider waiting for the new meds. How does your blood work look? Have you had a biopsy?
From my experience, I opted to treat with the interferon and riba for 24weeks. Four months post treatment and still UND. I decided to treat because I had the virus for about 5 years, I was 27 at the time I started it, and my over all health was very good. I tolerated the interferon very well, but it seems that everyone's reaction to the medication differs.
You are 46, I am not sure how long you have had the virus, but if your health is poor going into interferon treatment, it tends to exacerbate any health problems you have throughout the duration of the treatment. I know a lot of folks that went through it. It was tough, but they made through and don't have HCV anymore. Have you spoken with a doctor about treatment options?
Take care!
There is a lot to take into consideration with this question. The new interferon free treatments are just around the corner, so if you haven't had the virus long or don't have much liver damage, you may want to speak with your doctor and consider waiting for the new meds. How does your blood work look? Have you had a biopsy?
From my experience, I opted to treat with the interferon and riba for 24weeks. Four months post treatment and still UND. I decided to treat because I had the virus for about 5 years, I was 27 at the time I started it, and my over all health was very good. I tolerated the interferon very well, but it seems that everyone's reaction to the medication differs.
You are 46, I am not sure how long you have had the virus, but if your health is poor going into interferon treatment, it tends to exacerbate any health problems you have throughout the duration of the treatment. I know a lot of folks that went through it. It was tough, but they made through and don't have HCV anymore. Have you spoken with a doctor about treatment options?
Take care!
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