Several questions were raised in the thread:
http://www.medhelp.org/posts/Hepatitis-C/What-is-absolute-Neutrophils/show/1280368
about the causes of HCV treatment induced neutropenia (low neutrophil counts) and I thought it would be interesting to learn more about this part of treatment.
Specifically, they are:
- what is the incidence of neutropenia due to interferon monotherapy?
- what is the incidence of neutropenia due to ribavirin monotherapy?
- what is the incidence of neutropenia due to SOC treatment?
- how does interferon lower neutrophil counts?
- how does ribavirin lower neutrophil counts?
- what are appropriate steps in dealing with treatment neutropenia?
I will start by setting what I think I know about the subject aside and go to my personal treatment history, but hope to follow up with some answers sourced in literature.
First of all, neutropenia may be defined in a number of ways so we need to keep in mind that different studies may use different levels. The normal range for absolute neutrophil counts in a healthy person is 2,000-10,000 cells per microliter of blood syrum and doctors start to get concerned when the number drops below around 1,000. Both upper and lower limits vary by lab doing the bloodwork.
My own personal absolute neutrophil counts from SOC treatment were:
baseline prior to treatment ~4,000
at the start of the 3rd week ~3,200
at the start of the 5th week ~2,100
in the 8th week they were ~1,900
in the 12th week they were ~1,100
they continued to slowly decline until week 21 when they reached a low of 860 and have bounced back to fluctuate around 1,200 ever since. I have never taken any neupogen although I have been on and off of procrit for my hemoglobin. I'm currently in week 51 of treatment.
HCVguy