I picked up on that also (anemia), and posted it in a prior post during one discussion when the original news release came out along with several other points. If the two companies could collaborate to identify what specific compound in each caused the anemia and alter that specific compound in an off setting way, (more in one and less in the other) without altering any other components of each drug and have the same end results at this stage of the evolutional cycle, I think there would be the magic bullet both are seeking.
Andiamo1, I agree with your post, CTA is always the best policy.
I will post this to jmjm insightful posts about VX seem like there will be a lot of debate.
jasper
lastly on anemia, I think it certainly has to be looked at in light of recent labeling changes to epo.
Oh well, speaking of anemia, off for my 2 donut and 4 riba breakfast (g)
"and of course severe anemia can lead to heart attack" exactly. If you take any large group of people, there is a reasonable probability that one of them might have a heart attack. If you make them all anemic, you increase that probability.
The consent forms we sign have to list every major event that occurs while in treatment, so they list heart attacks. This does not mean there is any cause and effect link between heart attacks and Telaprevir.
I worry that this thread might influence someone not to take it and that could end up as a very bad decision made for the wrong reason.
and of course severe anemia can lead to heart attack
Seems like some of what is being listed here is a result of TVR in combo with soc, as opposed to singling out the TVR events minus soc..
This little blurp appears to narrow the profile to tvr alone
"Consistent with prior studies, the adverse event profile showed that skin events, nausea and anemia are the most important AE’s associated with TVR"
I think that anemia might be an important concern, especially when tvr is dosed with ribavirin which obviously has it's own anemia problems...kind of a double whammy anemia thing..
I agree with you. I took this into consideration before I signed the consent as I have a family history of heart problems. It is mentioned as an uncommon side. Who knows if it was treatment related or not. Any adverse events that occur during all trials have to be reported to the FDA whether it is treatment related or not.
By the way, are you still dose reduced on your riba?