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Avatar universal

Well boys & gals, had to stop my riba today.

How long will I maintain a useful amount of riba in my blood? I was 100% compliant until 1/30, that is 26 weeks. I suffer migraines and they have progressively become more numerous the last 3 months. I decided I was gonna make 24 wks no matter what. Was intending to do 36 weeks as a RVR. Starting last tues. EVERY time I took my Riba I got a headache. Imitrex is the only thing that works for me but you are not supposed to take more than 4 doses per month. My Neuro. says 8 doses a month are safe. 1 or 2 doses a day is NOT good. Gonna see if I can get in to see him but he can be tough to get to. Soooo, back to my ???. I know riba has a very long 1/2 life. Anyone know how long I can go without it before re-starting it would be a waste? jerry  
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Avatar universal
I too had read something along these lines and you have bought it back to my very weary mind. thanks for the good word, jerry
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Avatar universal
HCA
Riba reduction in RVR patients post week 16 does not prejudice SVR.
There was a good study on this but I didn't bookmark it.(Don't bookmark anything now).
Role of riba critial in first 16 weeks to supress design of successful variant.
I would be surprised and disappointed if you don't clear.
The half life is not really an issue.
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Avatar universal
I was able to achieve undetectable with a dose as low as 200 mg. of ribavirin + ifn. Riba caused severe gastrointestinal problems for me along with anemia. That was over the course of many years of treatments. Unfortunately I've always had rebound. Never got an SVR. I am amazed you made it this far with such a high dose. I don't recommend you go that low however.
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Avatar universal
Yeah, I tried reducing, first to 1000mg, then 800, then 600, no luck. No riba yesterday but still picked up a headache last nite. The migraines were my main concern when deciding treatment. I feel fortunate to have made it as long as I did with out them becoming chronic. Any reason you can think of for me not not to continue on with the Peg/Alinia? (asuming the migraines back off) jerry
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Avatar universal
If you werent taking Alinia, you would be risking breakthru and/or Relapse.
So you would be better off dose reducing to 600 and see if that helps.
As you are taking Alinia who knows.
And as you well and truely RVRed then 24 weeks may well have been enough.
You are taking a risk, but in my opinion not a very big one.

The riba half life is 12 days.

CS
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Avatar universal
283,000vl. Yes, my hope also. I plan on continuing the Peg/Alinia for the additional 12 weeks at least. jerry
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