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How long will the Incevick stay in your system?
I'm on week 12 of the incevik (tx) can anyone tell how long it stays in the system after completion and how long will the side effects stay as well?
Welcome to the forum.
If you have been off the Incivek for 7 days, then you are no doubt still taking the Interferon and the Ribavirin. The nerve stinging, like biting sensations, or like steel wool, or crawling sensations, are probably from the Interferon, not from the Incivek. I took Incivek but those sensations never even started until I was almost finished with Incivek or even until I was completely finished with it. I was on Interferon and Ribavirin for a total of 48 weeks. Those biting, stinging sensations gradually decreased after I finished taking the Interferon, but it took months for them to completely disappear. I know they are very uncomfortable and annoying, but try to hang in there. If you attain SVR (cure) it is all worth it.
The itching may be from the Incivek but the Ribavirin can also cause itching. If it was from the Incivek, it will gradually decrease. However, if it is from the Ribavirin, and it continues, ask your doctor for a stronger antihistamine, such as prescription Hydroxyzine, for the itching. I was on Hydroxyzine 50 mg every 6 hours as needed for the itching. If you have a rash, ask your doctor for a stronger Hydrocortisone preparation, a prescription Hydrocortisone cream or ointment. I used Fluocinomide ointment and Hydrosone Valerate cream for the rash. The itching can be treated and controlled with prescription medications so there is no need for you to be suffering from the itching.
Also, use a very good body cream such as Eucerine cream which will help with the dry skin. Other tips would be to keep your home cool (68 degrees or less, wear loose light weight cotton clothing, avoid the sun and the heat, sleep with light covers and sleep in soft cotton sheets, avoid all picky fabric and cut out all neck tags. Avoid anything that makes you hot or itchy. Sleep with fans on to cool you at night. There are lots more suggestions but the main thing is to avoid getting hot and to avoid irritating the skin.
Hang in there. Treatment is not easy but it is worth it to attain SVR.
Best of luck.
If you have been off the Incivek for 7 days, then you are no doubt still taking the Interferon and the Ribavirin. The nerve stinging, like biting sensations, or like steel wool, or crawling sensations, are probably from the Interferon, not from the Incivek. I took Incivek but those sensations never even started until I was almost finished with Incivek or even until I was completely finished with it. I was on Interferon and Ribavirin for a total of 48 weeks. Those biting, stinging sensations gradually decreased after I finished taking the Interferon, but it took months for them to completely disappear. I know they are very uncomfortable and annoying, but try to hang in there. If you attain SVR (cure) it is all worth it.
The itching may be from the Incivek but the Ribavirin can also cause itching. If it was from the Incivek, it will gradually decrease. However, if it is from the Ribavirin, and it continues, ask your doctor for a stronger antihistamine, such as prescription Hydroxyzine, for the itching. I was on Hydroxyzine 50 mg every 6 hours as needed for the itching. If you have a rash, ask your doctor for a stronger Hydrocortisone preparation, a prescription Hydrocortisone cream or ointment. I used Fluocinomide ointment and Hydrosone Valerate cream for the rash. The itching can be treated and controlled with prescription medications so there is no need for you to be suffering from the itching.
Also, use a very good body cream such as Eucerine cream which will help with the dry skin. Other tips would be to keep your home cool (68 degrees or less, wear loose light weight cotton clothing, avoid the sun and the heat, sleep with light covers and sleep in soft cotton sheets, avoid all picky fabric and cut out all neck tags. Avoid anything that makes you hot or itchy. Sleep with fans on to cool you at night. There are lots more suggestions but the main thing is to avoid getting hot and to avoid irritating the skin.
Hang in there. Treatment is not easy but it is worth it to attain SVR.
Best of luck.
how long does the nevere sting and inching last..it feels like something biteing me and sting and inching all at the same time,and there is know bite marks or rash..ive been off incevick for 7 full days now...
I'm am so thankful that the flaming butt was gone at week 8, but the nausea, dry mouth , tiredness just to name a few are still there.What's funny is I have gain 10 pounds well I guess not to funny on my part lol.
I got this far so I'm praying this new drug to work I still have to stay on the Interferon/Riba for 3 more month which I'm not really clear why that is, so I will ask my GI at my next appointment.
I got this far so I'm praying this new drug to work I still have to stay on the Interferon/Riba for 3 more month which I'm not really clear why that is, so I will ask my GI at my next appointment.
Flaming butt is gone as well as nausea but last 2 wks were tough, I lost 4 pounds and could only choke needed fat grams for pills so still weak and beat up feeling
So it clears out fairly fast. I figured the side effects will probably stay for a while. I just hope they calm down some so I can try and get back to some sort of a normal life. Thanks so much.
Elimination
Following administration of a single oral dose of 750 mg 14C-telaprevir in healthy subjects, 90% of total radioactivity was recovered in feces, urine and
expired air within 96 hours post-dose. The median recovery of the administered radioactive dose was approximately 82% in the feces, 9% in exhaled air and
1% in urine. The contribution of unchanged 14C-telaprevir and the R-diastereomer of telaprevir towards total radioactivity recovered in feces was 31.9% and
18.8%, respectively. After oral administration, the apparent total clearance (Cl/F) was estimated to be 32.4 L/h with an inter-individual variability of 27.2%.
The mean elimination half-life after single-dose oral administration of telaprevir 750 mg typically ranged from about 4.0 to 4.7 hours. At steady state, the
effective half-life is about 9 to 11 hours.
http://pi.vrtx.com/files/uspi_telaprevir.pdf
I'm 6 days post incivek and am still pretty beat up feeling from last 2 wks of incivek
Following administration of a single oral dose of 750 mg 14C-telaprevir in healthy subjects, 90% of total radioactivity was recovered in feces, urine and
expired air within 96 hours post-dose. The median recovery of the administered radioactive dose was approximately 82% in the feces, 9% in exhaled air and
1% in urine. The contribution of unchanged 14C-telaprevir and the R-diastereomer of telaprevir towards total radioactivity recovered in feces was 31.9% and
18.8%, respectively. After oral administration, the apparent total clearance (Cl/F) was estimated to be 32.4 L/h with an inter-individual variability of 27.2%.
The mean elimination half-life after single-dose oral administration of telaprevir 750 mg typically ranged from about 4.0 to 4.7 hours. At steady state, the
effective half-life is about 9 to 11 hours.
http://pi.vrtx.com/files/uspi_telaprevir.pdf
I'm 6 days post incivek and am still pretty beat up feeling from last 2 wks of incivek
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