Aa
blood tests
got a copy of my week 12 results, undetectable, hcv antibody high (>11), wbc alert 1.7 platelets alert 99
i see dr tomorrow ...should i be worried about my wbc and platelet #'s im wondering if they are going to suggest rescue drugs or transfusion or dose reduction ...
i see dr tomorrow ...should i be worried about my wbc and platelet #'s im wondering if they are going to suggest rescue drugs or transfusion or dose reduction ...
levels are coming back up, no dose reduction or rescue drugs, starting to feel alot better more energy etc... 8 more weeks to week 24 and hopefully that will be it...
Hi fret, yes i know where your coming from, what i have a problem wraping my head around is that these same people suggest that certain people should extend tx to 48 weeks but dose reducing is also ok. i've read here where people are reducing up to half their meds, some even stopping and starting. Yet the same people are not saying if you don't reduce then you don't need to extend tx.
From reading the trials there wasn't a whole lot of cirrhotics, or other hard to tx people in them to compare with........... And the ILB28 testing wasn't even being done until the very end.
My doctor who was also the Principal investigator for boceprevir, at least by my experience wasn't very fond of dose reducing.
Hope all is well with you guy.
From reading the trials there wasn't a whole lot of cirrhotics, or other hard to tx people in them to compare with........... And the ILB28 testing wasn't even being done until the very end.
My doctor who was also the Principal investigator for boceprevir, at least by my experience wasn't very fond of dose reducing.
Hope all is well with you guy.
There's a bit of information mentioned in the AASLD guidelines. All I'm saying is people should not stress about a dose reduction if they're on triple therapy. It's in there under "Adverse Events".
http://www.aasld.org/practiceguidelines/Documents/2011UpdateGenotype1HCVbyAASLD24641.pdf
http://www.aasld.org/practiceguidelines/Documents/2011UpdateGenotype1HCVbyAASLD24641.pdf
It seems more and more we are hearing(at least on the forum ) that doctors ,with the addition P.I'S are less concerned about dose reductions ,if you are UND. early.
The success rate in some of the studies,bore that out... reducing was less of a concern than in the past on SOC.
Treating in the general population ,it is probably to early to know for certain ,if this will be the case or not,however personally ...I would still be somewhat nervous about reducing ,unless it was an absolute last resort,or not doing so ,would be detrimental to my treatment.
Good luck..
Will
Thats a great question
The success rate in some of the studies,bore that out... reducing was less of a concern than in the past on SOC.
Treating in the general population ,it is probably to early to know for certain ,if this will be the case or not,however personally ...I would still be somewhat nervous about reducing ,unless it was an absolute last resort,or not doing so ,would be detrimental to my treatment.
Good luck..
Will
Thats a great question
So your saying someone that has a lot of liver damage, maybe a type CT or TT who also was a prior slow responder to SOC should just dose reduce?
You might be right, i just don't buy it.........
You might be right, i just don't buy it.........
"They said dose reduction first, rescue drugs second... i am starting to think with this new triple therapy if you respond well (undetectable from almost the beginning) they are not so concerned about dose reductions of the peg/riba later on ... because the chance of the virus coming back is low ... maybe???"
I absolutely agree with that line of thinking. A dose reduction is definitely the way to go with either of the triple therapies. I know some people are dead set against it but they should'nt be. good luck!!
I absolutely agree with that line of thinking. A dose reduction is definitely the way to go with either of the triple therapies. I know some people are dead set against it but they should'nt be. good luck!!
so, the dr is talking a dose reduction of the peg for the wbc issue and a dose reduction of the riba for the hemo/rbc but not yet... waiting on results from blood test yesterday the hope is levels will be stabilized or even get better now that i am off the Incivek ...
They said dose reduction first, rescue drugs second... i am starting to think with this new triple therapy if you respond well (undetectable from almost the beginning) they are not so concerned about dose reductions of the peg/riba later on ... because the chance of the virus coming back is low ... maybe???
I dont know...just wondering if i should push for rescue drugs instead of a dose reduction if it becomes an issue, i have read posts on this board for years where people fought with the drs to not do a dose reduction because of the chances of the virus coming back...
again, maybe with the triple therapy maybe that is not such an issue anymore???
They said dose reduction first, rescue drugs second... i am starting to think with this new triple therapy if you respond well (undetectable from almost the beginning) they are not so concerned about dose reductions of the peg/riba later on ... because the chance of the virus coming back is low ... maybe???
I dont know...just wondering if i should push for rescue drugs instead of a dose reduction if it becomes an issue, i have read posts on this board for years where people fought with the drs to not do a dose reduction because of the chances of the virus coming back...
again, maybe with the triple therapy maybe that is not such an issue anymore???
Many congrats on your UND, great news!. Hope the blood helps you right away!! WTG!!
Congrats on your UND results. Since my hgb dropped so did the platelet, WBC, RBC counts. My NP reduced my RIBA to 800 mg and my hgb has stayed at 10.7. Had CBC drawn today and have doc appointment on Thursday. Hoping for a good CBC result and and UND status. On week 7.
looks good ! ....i would do weekly cbcs..keep an eye on things...good luck...billy
Your blood counts looks like somebodys on tx and it seems to be working, platelets are good, mine was only 80 when i started.
Best to you
Best to you
Glad to hear u got ur results! Woohoo! Maybe some rescue, let us know what Dr says. Karen :)
thanks ya i was <43 at wk 2 and undetectable at week 4 also so prob only have another 10 wks to go to do a full 6 month hope i make it lol
At week 12, Hgb @ 10.7 is something to watch since it may continue to go down over time. Usually most doctors will consider Procrit at 10.0. Your wbc's appear low, but usually they watch the ANC (Grans). I'd suspect you'll also be talking about neupogen to boost the wbc's. Fortunately, the neupogen usually works very quickly for the wbc's, but the Procrit often takes weeks to respond. Talk to your doctor about both.
I'm not that familiar with the platelets, but although out of range, not low enough to worry yet. Hope this helps. Best of luck to you.
I'm not that familiar with the platelets, but although out of range, not low enough to worry yet. Hope this helps. Best of luck to you.
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