breakthrue

[bahamasnut]

Can a breakthrue be reversed by doing tx again ?

[Willy50]

(i wrote)
." there are not often many trials which treat g-3's."
=========================================
What I mean to say....what would be more accurate is that many trials will attempt to treat genotype 3's, but generally speaking there have been fewer trial arms and smaller quantities of g-3's in trials conducted in the United States.  Genotype 1 is the genotype that has been getting most of the attention in the US since that is the hardest to treat w/ SOC and the most prevalent.

willy

[curiouslady1]

The Pharmasset trial that he may have been eligible for is unfortunately taking place in NZ. . . a bit of a trek from Virginia.  But keep checking clinicaltrials.gov as "Chance favors the prepared mind"

[Willy50]

My take on it is this;

If your hubby just broke through and wanted to take another "swing" at TX if he were doing the same form of TX he would likely have the same result.  In some ways....since he may have a more resistant group of virii he could even have less response.

To overcome this people take to more extreme measures.  Cocksparrow was a non-responder, if memory serves, and so he knew that his immune response was possibly insufficient.  Therefore he took certain measures to stack the cards more to his favor.  One of those factors, as lynda pointed out was IR; insulin resistance.  He changed his diet, lost weight and his IR factor changed.  IR can negatively affect ones immune response.

CS did a number of supplements, one was alinia, he predosed riba and high dosed it as well and when he started interferon..... if memory serves he started with a more frequent regimen; maybe a shot every five days....then 6 days and then to a normal 7 day interval.  This is a rather shorthand version.  There are several threads where it is described in detail.  It was effective; he had been a nonresponder his first time and if memory serves, he was nearly undetectable at 2 weeks, but got his RVR and treated....once again if memory serves.....about 36 weeks.  He has been SVR for several years now.  He succeeded but it was a very hard TX.

The newer forms of TX look very attractive.  IF your hubby can wait I would also explore those forms of TX as well as the TX that CS succeeded with.  I believe there are some decent trials right now and there will be in the future as well, although....be forewarned.... there are not often many trials which treat g-3's.

best,
willy

[lynda607]

Sorry about the genotype mix up.  From reading previous posts, I have read that a member of this forum called CoWriter worked with a previous member called Cocksparrow who is genotype 3 and a relapser and together they devised a treatment protocol  by which Cocksparrow ultimately achieved SVR.  You may want to PM her and perhaps she could provide the treatment protocol they used.

Here is her profile page:
http://www.medhelp.org/personal_pages/user/568322

[bahamasnut]

Thank you linda, one thing is he is geno 3 and i have read that i someone has a breakthrue on tx it will be hard  to achieve svr if teatment is done again?

[lynda607]

In order for your husband to have any chance at SVR being a geno 2 he would have to do at least 48 weeks of interferon and ribavirin next time.

Maybe check for insulin resistance?  He responded well to interferon having gone UND at 4 wks but it did not work well enough with the immune system to suppress the virus.  Was he taking ribavirin according to his weight or was he taking 800 mg?  Ribavirin stops the virus from replicating and plays a key role in ultimately eradicating HCV when pegylated interferon and ribavirin are used and sometimes more ribavirin will accomplish the task.

In any event, he needs some time to recuperate from the last treatment and if he chooses to treat again then he and his doctor can talk about tailoring the second treatment.  There are also some Pharmasset trials that involve geno 2 & 3 and have had very good results.