geinotype2 hepc kidney diseasse

[bluebird305]

I am a genotype2b virus. and advanced cirrhosis and 3rd stage 3 kidney disease.  Can anybody tell me the complications that may occur during treatment as I know that the interferon and rib attacks the other organs.  Should I wait for the new treatment.  I am also taking mental pills for depression and anxiety.  I would be grateful for any feed back.  Thanks a lot   Bluebird305

[HectorSF]

Only your hepatologist at a liver clinic or transplant center who knows your complete health status can determine if it is safe to do HCV treatment or not. There are too many individual factors that we don't know about to offer an educated opinion. Beside we are not experienced with kidney disease which is obviously a serious matter as kidneys commonly fail when liver failure occurs.

You say you have advanced cirrhosis? What do you mean?
If you are decompensated, which is what is commonly meant by "advanced cirrhosis", you liver is probably too damaged to tolerate any interferon based treatment. As the label for peg-interferon says "contraindicated in patients with decompensated hepatic disease prior to or during treatment".

Also there are issues using peg-interferon and ribavirin in patients with kidney disease.
"This drug (interferon) is known to be excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function."
"..should be used with caution in patients with creatinine clearance <50 mL/min"

Ribavirin
Based on the pharmacokinetic and safety results from this trial, patients with creatinine clearance less than or equal to 50 mL/min should receive a reduced dose of COPEGUS; and patients with creatinine clearance less
than 30 mL/min should receive a reduced dose of PEGASYS. The clinical and hematologic status of patients with creatinine clearance less than or equal to 50 mL/min receiving COPEGUS should be carefully monitored.
Patients with clinically significant laboratory abnormalities or adverse reactions which are persistently severe or worsening should have therapy withdrawn.

Gilead's Sofosbuvir +Ribavirin all oral, none interferon treatment for genotype 2s with be available in early 2014.

Talk to your hepatologist.
Good luck to you!
Hector

[Advocate1955]

Hi Blue,
Only your hepatologist can answer that question. It all depends on how advanced your liver damage is, as there are various "stages" of Cirrhosis. I believe I recall that you have two symptoms indicating a stage called "decompensated cirrhosis" (ascites-fluid build up, and HE-Hepatic Encephalopathy-confusion, memory problems, forgetfulness, fatigue, etc). Your hepatologist may decide that treating with Interferon and Ribavirin (the two drugs that are used right now for G2's) would be too hard in your liver. He/she may decide it would be best to wait for a new treatment and focus on taking excellent care of your liver til then.
It's great to see you posting a question. :)
Advocate1955