geno type

[nio79]

So i did my geno type and the Dr i saw never heard it before she say, it is geno type 3k. anyone knows or experience this genotype? And how is the treatment, is That a rare geno type and how is the succes rate for treating That particular type?

[Shyrlgame]

Okay I have found reference to your genotype:


The biochip contains 120 oligonucleotides that identify genotypes 1 to 6 and 36 (1a, 1b, 1c, 1d, 1e, 2a, 2b, 2c, 2d, 2i, 2j, 2k, 2l, 2m, 3a, 3b, 3k, 4a, 4c, 4d, 4f, 4h, 4i, 4k, 4n, 4o, 4p, 4r, 4t, 5a, 6a, 6b, 6d, 6g, 6h, and 6k) subtypes.

And as well 7,8 & 9, that Dee referenced.  

So is not a typo!  But you could find lots of refernce to genotype 3 and be sure that treatment protocol would be the same.

[Shyrlgame]

Apparently 3k is common among blood donors in Indonesia.

[ActingBrandNew]

Im not sure but I will go through my bookmarks after this to verify but I believe that genotype 3k used to be genotype 10a but was reclassified. 3k is most prevalent in Indonesia and Iran if my memory serves right. Again, I will look after I post this.

[ActingBrandNew]

Prior to 1994, new variants were identified in Vietnam, Thailand, Burma and Indonesia. These viral genotypes were originally classified as genotypes 7, 8, 9, 10 and 11. These variants were reclassified in 2005; genotype 10a came to be denominated subtype 3k, and genotypes 7a, 7d, 7b, 7e/7c, 11a, 9a, 9b, 9c, 8b and 8a became subtypes 6e, 6c, 6d, 6f, 6g, 6h, 6i, 6j, 6k and 6l, respectively [1].

http://www.scielo.br/scielo.php?pid=S1413-86702007000700009&script=sci_arttext

[ActingBrandNew]

Besides being a Genotype 3k, how is your liver? Have you had a biopsy? If so do you have any fibrosis? Has your doctor mentioned  fatty liver (hepatic steatosis)?  What is your viral load? I see you are <40 so that is a plus. A little more information can be helpful.

Sofosbuvir will hopefully be on the market soon but the only plus side for a Genotype 3 with that is the fact you will not have to take interferon. Studies have shown it to be not as effective for a G3 as it is on others.

EASL 2013: Sofosbuvir + Ribavirin Cures Most Genotype 2 Hepatitis C, but Genotype 3 Response Is Lower

http://www.hivandhepatitis.com/hepatitis-c/hepatitis-c-topics/hcv-treatment/4081-easl-2013-sofosbuvir-ribavirin-cures-most-genotype-2-hepatitis-c-but-genotype-3-response-is-lower

[desrt]

You are correct in anticipating the possibility of depression type feelings with interferon therapy. A lot of doctors even start their patients on an SSRI type anti-depressant like Prozac a couple weeks before starting treatment. It's not quite as bad as it sounds, though some patients do describe it (at least a couple days each week) as being similar to withdrawal. The SSRIs actually seem to make this more bearable on a physical basis and are not just a happy pill.
If you do choose to go with the current standard of care (pegylated IFN and ribavirin, and yes it's the IFN that causes the depression and 'flulike' feelings) there are some additional tests like the IL28B that can help guide your treatment decisions as you go along.
Good luck whatever you decide.

desrt
former 3e
(and yeah, I used to get the 'typo' thing too)