Aa
genotype 1b....... anyone else 1b
i've read so much about.genotype 1b.most of it is very scary.. is there anyone that is 1b that has some good news to share. i'm so worried, i'm beginning to cry & pray every night. i haven't started treatment yet, but me and doc have talked about maybe starting at the end of the year.
I am really sorry you feel in that way. Easy to say not to worry, but it will get better once the shock is subsiding. I had some homeopathic help to get over that
I have been recently diagnosed as well, 1b and the IL28 is CT, not the best position to be in. I have been told that on Interferon and Ribavarin, response rate is 30%.
Telaprovir is not funded yet where I live, will be in 12 months. That would have been increase the chance at 60%. Don't you find these numbers somehow irelevant sometimes. If it meant to be it will be. It is crazy, I had only numbers in my head for the last 3 months. I pretty much managed my case and at last I have a good team. In 4 days I will find out if I am starting the Interferon or if I am still waiting. In the mean time I am trying to do my best, and get my body in the best place physically and mentally so I will be able to cope with the treatment.
I have been recently diagnosed as well, 1b and the IL28 is CT, not the best position to be in. I have been told that on Interferon and Ribavarin, response rate is 30%.
Telaprovir is not funded yet where I live, will be in 12 months. That would have been increase the chance at 60%. Don't you find these numbers somehow irelevant sometimes. If it meant to be it will be. It is crazy, I had only numbers in my head for the last 3 months. I pretty much managed my case and at last I have a good team. In 4 days I will find out if I am starting the Interferon or if I am still waiting. In the mean time I am trying to do my best, and get my body in the best place physically and mentally so I will be able to cope with the treatment.
GS7977 will probably not work for 1b, not by itself
It has 100% results for genotype 2 and 3. In the 1b case, after 12 weeks of treatment all but one from the 12 people involved in the trial did not maintain an SVR
It has 100% results for genotype 2 and 3. In the 1b case, after 12 weeks of treatment all but one from the 12 people involved in the trial did not maintain an SVR
With the new all oral drugs that are in clinical trials and hopefully out to market in the next few years, 1b's are actually doing a little better than 1a's. What stage are you? Haven't read all of the responses, so hope I'm not asking you to repeat yourself.
I'm also a 1b, and have my appointment friday about the new Gilead drug GS7977. Hoping I get it, short tx, only 12 weeks.... Keep your chin up, don't freak [we all do at some point], put one foot in front of the other and take the next indicated step, whatever that is for you. And don't forget to BREATHE!
1b also. Starting tx probably within the next couple of weeks.
Have a great day!
Jules
Have a great day!
Jules
yes i've had two biopsy. in 2004 grade 1, stage 0 and in 2011 grade 2, stage 1. so it's progressing, slow but still progressing.
I am also1b, Had my 3rd shot of Pegasys this morning. Experiece little sx so far,there are times i feel better than before i started treatment. I think it is my mind telling myself how better off iam now that iam taking care of this beast. It is so good and helpfull to read all of these post,I wish you all the best,you can beat this, you have so many friends here.
Welcome to the forum. I too WAS 1b.. Treated with Incivek.. UND at 4, 8, 12, and 24 weeks of treatment, and two months after treatment. I have my 6 month test coming up in August and I am maintaining positive thoughts that it too will be UND. Treatment is harsh, but the end game is worth it.. Have you had a biopsy yet?
It is also very normal to go to that bad place.. we all go through the stages.. denial, anger, depression, acceptance.. I might have missed one.. Anyway.. once you get to acceptance you will be in a much better place..
It is also very normal to go to that bad place.. we all go through the stages.. denial, anger, depression, acceptance.. I might have missed one.. Anyway.. once you get to acceptance you will be in a much better place..
you have fill me with hope. i was in such a bad place, that is hard to come back and read the post. i'm sorry it took me so long. i've had hep C a very long time and never had to think about it. as long as i didn't pass it on to anyone else. now with the disease progressing i have to think about treatment. thank you for sharing your stories with me. i pray that you all stay well and that it works for me also.
Welcome, I am 1b also. I treated on incivek. I was und at 4 weeks and was last tested at 3 months post, still und. I find out if I am svr next month and expect I am. I feel better than pretx now. Courage, the journey is tough, the reward is great. You can do this, many have over and over again. Now we will likely only need to do it once due to the new drugs. Just keep your eye on the goal.
Welcome... Am am 1b just finishing week 12 of triple therapy with telaprevir, pegasys and riba. I was UND at week 4 and 8. Will have 12 week draw in the morning. Hoping of course for a repeat of the UND. My treatment has gone well except for a bad bout of vomitting and such for 3 days that put me in the er for a few hours to hydrate. Closely following that was a round of mouth thrush that was promptly cured when meds were prescribed. Easy...NO... Manageable and worth it to be hep c free...ABSOLUTELY. This forum makes all the difference. Best wishes to you.....truly
I was also a 1b and from trial data thats the best subtype to have, our odds are a little better.
For boceprevir........ Due to a somewhat lower genetic barrier to the emergence of resistance, patients infected with genotype 1a HCV tend to fare less well, as reflected by the SVR rates, which were approximately 7% lower in genotype 1a patients compared with 1b patients
For telaprevir.........The presence of drug-resistant variants at treatment failure was less likely with subtype 1b vs 1a HCV infection. In addition, subtype 1b was found to revert to wild type more quickly than subtype 1a (P < .0001).[23] However, there is no current suggestion that patients should be treated or monitored differently based on HCV subtype; however, knowledge of subgenotype may allow counseling of patients on whether their subtype is a negative or positive predictor of success for the triple-therapy regimen. Finally, as mentioned previously, cross-resistance between boceprevir and telaprevir is anticipated due to the overlapping resistance mutations, and therefore, it is unlikely that switching from one to the other upon failure will be effective.
http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2011%20Annual%20Update/Modules/DAA%20Naive/Pages/Page%206.aspx
For boceprevir........ Due to a somewhat lower genetic barrier to the emergence of resistance, patients infected with genotype 1a HCV tend to fare less well, as reflected by the SVR rates, which were approximately 7% lower in genotype 1a patients compared with 1b patients
For telaprevir.........The presence of drug-resistant variants at treatment failure was less likely with subtype 1b vs 1a HCV infection. In addition, subtype 1b was found to revert to wild type more quickly than subtype 1a (P < .0001).[23] However, there is no current suggestion that patients should be treated or monitored differently based on HCV subtype; however, knowledge of subgenotype may allow counseling of patients on whether their subtype is a negative or positive predictor of success for the triple-therapy regimen. Finally, as mentioned previously, cross-resistance between boceprevir and telaprevir is anticipated due to the overlapping resistance mutations, and therefore, it is unlikely that switching from one to the other upon failure will be effective.
http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2011%20Annual%20Update/Modules/DAA%20Naive/Pages/Page%206.aspx
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