Aa
great news!
Gilead Submits New Drug Application to U.S. FDA for Sofosbuvir for the Treatment of Hepatitis C
http://www.gilead.com/pr_1804362
It came out even sooner than most of us expected.
Hopefully, it is a start of a new era in Hep C treatment!
http://www.gilead.com/pr_1804362
It came out even sooner than most of us expected.
Hopefully, it is a start of a new era in Hep C treatment!
Thats encouraging! Surely we could adjust to a treatment without interferon and poly glycol (anti-freeze). :-)
Even though you are a G3 like myself...keep in mind that if you or I do relapse (God forbid) Sofosbuvir + Ribavirin are.....wait for it.....interferon FREE!
AND my friend...the study I posted above boasted a 62 percent SVR after only 16 weeks of therapy. I mean...it beats a blank.
I don't know...call me mister optimist....
AND my friend...the study I posted above boasted a 62 percent SVR after only 16 weeks of therapy. I mean...it beats a blank.
I don't know...call me mister optimist....
I agree that getting an 8 week VL won't change Tx plans. I was DET at week 4 and would have done 48 weeks regardless. But it was sure encouraging to know that I was UND at week 8.
I can understand your concern about relapse and wondering what Tx is available if you do. Currently, I don't think there is another Tx available other than those that are now in trials.
I do know that low maintenance interferon was used in the past but I do not think it is currently being used as maintenance Tx. Someone will correct me if I am wrong about that.
I also know that, in the past, some people, when they have failed treatment, lost weight and lowered their insulin resistance in order to correct or change some of the negative host factors that may have been affecting Tx outcome. Some also treated longer and with higher doses. Whether any of that is an option for you, I do not know. I just know that some people have done it in the past.
I can understand your concern about relapse and wondering what Tx is available if you do. Currently, I don't think there is another Tx available other than those that are now in trials.
I do know that low maintenance interferon was used in the past but I do not think it is currently being used as maintenance Tx. Someone will correct me if I am wrong about that.
I also know that, in the past, some people, when they have failed treatment, lost weight and lowered their insulin resistance in order to correct or change some of the negative host factors that may have been affecting Tx outcome. Some also treated longer and with higher doses. Whether any of that is an option for you, I do not know. I just know that some people have done it in the past.
Thank you Pooh.
I know you had a DET VL at 4 weeks. Did you have an 8 week VL test? If so, what was the VL? Also, were you able to increase your Ribavirin dose to 1200 mg a day.
My doctor said it wouldn't make any difference if we got a vl test at 8 weeks because it wouldn't change his tx plans. We will get a vl test at 12 wks. He did up the riba from 800 to 1000 after the 4 wk vl test. Both he and his nurse are so much better than the Gastro place that I first went to that it just doesn't seem right to push very hard on alternate directions. He was encouraged that the vl load had come down as far as it had given my age, weight and liver condition.
Actingbrandnew was concerned about his gen 3 virus coming back when his treatment ended. That made me wonder what if it does and what then?
I wonder why we couldn't go on a low maintenance dose of tx just to keep the vl load low. Or, is there another treatment to try?
You are most kind and helpful. Thanks again
nuhepper
I know you had a DET VL at 4 weeks. Did you have an 8 week VL test? If so, what was the VL? Also, were you able to increase your Ribavirin dose to 1200 mg a day.
My doctor said it wouldn't make any difference if we got a vl test at 8 weeks because it wouldn't change his tx plans. We will get a vl test at 12 wks. He did up the riba from 800 to 1000 after the 4 wk vl test. Both he and his nurse are so much better than the Gastro place that I first went to that it just doesn't seem right to push very hard on alternate directions. He was encouraged that the vl load had come down as far as it had given my age, weight and liver condition.
Actingbrandnew was concerned about his gen 3 virus coming back when his treatment ended. That made me wonder what if it does and what then?
I wonder why we couldn't go on a low maintenance dose of tx just to keep the vl load low. Or, is there another treatment to try?
You are most kind and helpful. Thanks again
nuhepper
"What is copeg?"
------------------------------------------
Copegas is Ribavirin.
"If 48 weeks of inf and riba doesn't achieve SVR, then what tx is available? "
------------------------------------------
There are several trials which are testing new drugs and/or old drugs in various combinations and hopefully one or more of them will be effective in treating Genotype 3.
I am providing some links to articles on Genotype 3. They may not give you the answers you seek but they are informative and may give you a better idea of the possibilities.
http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02715.x/full
http://www.medscape.com/viewarticle/739955
The following link has several articles on which you can click:
http://www.hepatitiscnewdrugresearch.com/genotype-3hcv-treatment.html
I know you had a DET VL at 4 weeks. Did you have an 8 week VL test? If so, what was the VL? Also, were you able to increase your Ribavirin dose to 1200 mg a day.
While I know it is very concerning and nerve wracking, try to do the best you can to get through treatment and hopefully succeed in attaining SVR. We are all in the same boat so we do understand how serious and how concerning the treatment and the waiting can be.
------------------------------------------
Copegas is Ribavirin.
"If 48 weeks of inf and riba doesn't achieve SVR, then what tx is available? "
------------------------------------------
There are several trials which are testing new drugs and/or old drugs in various combinations and hopefully one or more of them will be effective in treating Genotype 3.
I am providing some links to articles on Genotype 3. They may not give you the answers you seek but they are informative and may give you a better idea of the possibilities.
http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02715.x/full
http://www.medscape.com/viewarticle/739955
The following link has several articles on which you can click:
http://www.hepatitiscnewdrugresearch.com/genotype-3hcv-treatment.html
I know you had a DET VL at 4 weeks. Did you have an 8 week VL test? If so, what was the VL? Also, were you able to increase your Ribavirin dose to 1200 mg a day.
While I know it is very concerning and nerve wracking, try to do the best you can to get through treatment and hopefully succeed in attaining SVR. We are all in the same boat so we do understand how serious and how concerning the treatment and the waiting can be.
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