hepatitis c genotip 3 solution!!!

[vesnic]

hello from macedonia..I have one question..my brother is 25 years and he has this hepatitis c genotip 3..at the moment he is on therapy ..this therapy is one year..and I want to ask ..is there posibility for permanent solution for this situacion..I pray for him every day ..his my brother and I love him..his life is just begining..;((((((((((

[vesnic]

Thanks Willbb..I will try to  resarch every link that can be helpfull..
One more thanks ..and all the best ...;))!!!

[willbb]

Hi .below is a link to fairly recent reputable article that  has much info. about Geno 3 .  Present treatments,,predictors of response and possible future options.

Best to you and  your brother..
Will

http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02715.x/full

[vesnic]

Like I sad ..he is doing fine..he take the therapy...normal..he told me that his liver is clean..no damage at all..he made also biopsy..and now he is taking the therapy...first time was 6 mounts and now its one year..
he made also control of how is taking the therapy..so we wait the  resalts..
after two weeks i will know how is blood control going..so i will tell you about..
thanks to all who want to share information about heppatitis c genotip 3...

[Emily_MHManager]

Hi everyone -

This thread has gotten way off track.  If you would like to offer vesnic some support and info, please do so, but the back and forth has to stop in order to do that.

Emily

[BoceprevirGal]

thanx for this imfo, Guy

[BoceprevirGal]

He tried with the two and failed both times

[desrt]

"There is also a test, that can indicate success with the treatment, called a IL28B test. People with a CC marker, have a slightly better chance to cure, and then people with a CT (alle) marker. The people who are tougher to treat have a TT marker.

This is maybe what Boceprevir28wkGal was referring to.

http://www.gastrojournal.org/article/S0016-5085(10)00841-3/abstract

Background & Aims
Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa–induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to treatment with peginterferon and ribavirin in a well-characterized cohort of genotype 2/3 patients.

Methods
DNA was analyzed from 268 patients (Caucasian: genotype 2, 213; genotype 3, 55). Patients were randomly assigned to groups that received standard duration (24 wk; n = 68) or variable durations of therapy. Patients who received variable durations (VD) and had a rapid virologic response (RVR) were treated for 12 weeks (VD12; n = 122); those without an RVR were treated for 24 weeks (VD24; n = 78). IL-28B genotypes (rs12979860) were analyzed for association with treatment response

"Results
The frequencies of the IL-28B genotypes were as follows: CC, 37%; CT, 48%; and TT, 15%; 82% of patients with the CC genotype achieved a sustained virologic response (SVR), compared with 75% with the CT and 58% with the TT genotypes (P = .0046). Differences between IL-28B genotypes were greatest among patients who failed to attain RVR (VD24 SVR rates: CC, 87%; CT, 67%; and TT, 29%; P = .0002). Among patients with RVRs (61%), the IL-28B genotype was not associated with SVR (>70% for all IL-28B genotypes). In a multivariable logistic regression model, IL-28B genotype predicted SVR (odds ratio, 1.76; 95% confidence interval, 1.16–2.7).

Conclusions
An IL-28B polymorphism was associated with an SVR in patients infected with genotype 2/3 HCV who did not achieve a RVR. Analysis of IL-28B genotype might be used to guide treatment for these patients"



In other words, this test is only significant if your brother is still detectible at week 4.

[BoceprevirGal]

thanks Will

[BoceprevirGal]

I just left a message, for pooh, that I would also like you to read. I have been in contact with Emily, the Moderator, and have let her know about this lecture, as well, to lend credibility to myself.
  I would never use this site, as a "playground", being sick myself,and having empathy for others going thru what I have gone thru,and am going thru!

[BoceprevirGal]

I do attend weekly lectures, given by my Doctor. Many people have even traveled from different states, to set up appts with her,as many of her treatments give hope to those who have been turned down by other Doctors.
   At our last lecture, she mentioned that Booceprevir has shown some resluts, "in the test tube" for genotype 3, and she told us that she is prescribing it to one of her genotype 3 null responders.
   If anybody on here is serious about Hep C education, and would like to meet up with me (I'm in the S.F.Bay Area), I would be happy if they would accompany me to the weekly lecture, it is open to all!
  I dont feel comfortable posting the imfo via the internet

[BoceprevirGal]

I thought 35% was fairly high, so I am taking my Riba with two heaping tablespoons of peanut-butter (whichis 14 grams of fat) and two small containers of whole milk yogurt (each yogurt is 7 grams of fat)
   Of course, I also take a walk afterwards, and my weight has stayed the same. An avocado is also high in fat~

[BoceprevirGal]

I know of a geno type 3 that was just prescribed the triple tx with Victrelis, that's the only reason I mentioned it~ I sure hope it works for him

[BoceprevirGal]

Sure, here's one link, will look for more- not Teleprivir, just Boceprevir
http://www.natap.org/2011/APSL/APSL_03.htm

[BoceprevirGal]

Good, Vesnic...when he gets his 4 week viral load test, that can also help him see how the Interferon is working for him, with the Riba pills.
   There is also a test, that can indicate success with the treatment, called a IL28B test. People with a CC marker, have a slightly better chance to cure, and then people with a CT (alle) marker. The people who are tougher to treat have a TT marker. You can google this "IL288 test", to research, but the best thing is to just have your brother take his medicine on time, etc-
  The worst case scenario would be that he doesn't clear again, but the good news is, the Medical Field is finally making HUGE progress with curing Hep C, and they are hoping that within 20 yrs they will have a 100% cure for everyone with Hep C. They have already approved 2 new meds, the one I am on, Boceprivir, has shown hope,in the test tube, for being affective at specifically targeting the genotype 3...and they will be using these new meds, called Protease Inhiibitors, on people like your brother, who didn't clear the virus the first time.
   I caught the Hep C virus when I was 27 yrs, and did remain healthy and happy, for the next 20 yrs...it usually takes 20 yrs to start showing symptoms. Did your brother have a biopsy?

[vesnic]

thank you people for helping me to find something new ...that could help my brother  in his treatment...he is oki..but  a littele scared because first treatment didnt get the resalts that we wanted..so these one year therapy is too serios for him..and I always talk to him to be relax as posible he can be
he is too young....he has this virus 5 years..we waited the injection to aprove from state...and know he is takeing every week ..once this therapy..but also drink a lot of tablets....so it is important the food that he is takeing..
one more thanks to all..so if you have something that can help I am here to see ...

[BoceprevirGal]

I have read that the Ribavirin does absorb better, when taken with 27 grams of fat. So, when he takes his pills, he can put two large tablespoons of peanut butter on bread, and 2 large whole milk dairy items, like tow yogurt containers, etc. There was also a study thatmentioned coffee helps, (although they dont know why)..so I put half-and half (cream) in, with the coffee, that has lots of fat.
   I also would think that too much fiber (grains, veggies) might send the ribavirin thru the digestive tract too quick, so I avoid alot of roughage, unless I need it, and then I do it in the middle of the day, inbetween Riba doses...good luck with your little brother.

[Bill1954]

Vesnic, there aren’t any specific dietary restrictions for HCV patients unless they have cirrhosis or problems with iron storage. If there is a particular concern discuss it with your brother’s doctor.

Good luck to all,

--Bill

[vesnic]

thanks Bill..I hope that everything goes well..he is too young ..and has  a lot to give in this life..He is in good psyhological condicion..he is positive ..but insade I feel he is scare to dead ..because in the first therapy he was diferent with a lot of expectation..and now  he is trying  to give all from hisself to get try this disise..hmmm:((((((

[vesnic]

yes its true..first he was at six mounts therapy but the resalts were positive so now he is on one year therapy..
can you tell me information about what kind of food he has to eat ..or something ..thanks!!

[BoceprevirGal]

Yeah, if you read Vesnics' post, he did mention his brothers' treatment was one year. Perhaps his brother tried tx with 6 months, and it returned. I think once this happens, then they treat for a year, but only the OP has this imfo

[mykids247]

g 2 here also. 24 weeks and not a minute longer.

[orphanedhawk]

Treatment for genotype 2 and 3 is usually 24 weeks.
I just completed tx.

Bo~ please check your facts and/or wording before posting.

[BoceprevirGal]

Sorry about your brother. Did a liver biopsy indicate his liver was scarred, at such an early age. Lots of times, Hep C takes 20 yrs, to damage a liver. Genotype 2 and 3 is more easily treated, then genotype 1, and many people have cleared, after a year of treatment.

[Bill1954]

Hello Vesnic, and welcome to the discussion group.

Yes, assuming he is currently using pegylated interferon and ribavirin, he has roughly 70% odds of successful, permanent clinical resolution.

The term used is ‘SVR’, or Sustained Viral Response. This occurs when the patient completes his prescribed treatment with undetectable viral status; then six months after treatment if the virus is still undetectable it will not return.

Good luck to both your brother and your family-

--Bill