i think i have had viral breakthough due to huge interferon reduction at week 5

alico222

I think I have had a viral breakthough when I was reduced at week 5 to 90mg interferon, as I had night sweats etc.
Does anyone think this is the virus out in the open. Is it worth me carrying on with treatment.
Thanks
Alico.

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Best Answer

paen53

I'm just curious.....was your INF decreased to 90 mcg based only on the night sweats? What were the etc.'s? Have you had a 4 week PCR run yet? I would push for a PCR as soon as possible - that's a huge cut in meds so early in the game. If there wasn't a life threatening reason for the decrease, I would run, not walk to a new Dr. These early weeks are SO important in reaching UND and ultimately SVR.

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willing

viral breakthrough during tx is a tiny jump in VL from (likely) present but UND to detectable. As Trish points out you won't find a qualified Dr. anywhere on the planet who will attribute that small shift in VL to any physiological change(night sweats, increase decrease in AST/ALT, joint pain, etc.). However that small shift does have a major impact on your tx outcome. Successful tx depends on VL heading in one direction only: down, down, down.

I'd suggest forgetting the night sweats and focusing on understanding the reason for the dose reduction. A sensitive PCR may confirm breakthrough, but even an UND result doesn't mean your tx wasn't jeopardized by the reduction. hcvjames may be a good contact as he underwent a couple of "restarts" on his last tx.

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AKHepper

you need to ask them about neupogen

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alico222

I think I need to clarify the night sweats were after I was reduced. The reduction but in one swoop was to 90 because neutrophils dropped to 0.5
Alico

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mikesimon

I'd want a PCR if you can get one.
Is that possible?

Mike

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alico222

is ther anywhere i can go for expert specialist advice as to what i should do now?

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AKHepper

interferon reduction is no good, pretty sure that's why I relapsed back in 2004. They didn't know about rescue drugs back then, I guess. No excuse for it now.

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