Aa
liver stages
Havent heard anyone here start out their journey of Hep C with LIVER FAILURE...I never felt sick untill the chain of events started...healthy...even healthy enough to under go surgery, got a slice on my throat...ear to ear....being co-infected(hepB and C) starts out LIVERFAILURE? Is there a site to help someone like me understand co-infection and how its different..liver failure seams to likely to happen at the long end of the field...NOT IN THE BEGINING...right??....maybe if I could educate myself better I wont feel that my change of fighting this as others are...feeling like I am coming in on the later part of the movie ..and it will end before I even get to chance to try !!! all the references Ive been given is either one or the other...NOT BOTH AND IS TREATMENT AVAILABLE FOR THOSE CO-INFECTED??? THANK YOU....finding me that reference will keep me not so bothersome on wanting answers now!!! (smile)
Sorry i can't find a more recent link about co-infection with HCV and HBV than this 2005 article. I did recently see something more up-to-date and maybe someone else will know.
"Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is not uncommon, particularly because of similar routes of infection. In HBV-infected patients, the rate of HCV coinfection ranges from 10% to 30%.[1]
Patients who are coinfected have various serologic and virologic profiles and a diverse spectrum of disease. Dual infection with HBV and HCV is associated with more advanced liver disease and an increased risk of hepatocellular carcinoma (HCC), making consideration of treatment for such patients a priority.[2,3] Treatment of coinfected patients is challenging and has not been well studied. The limited published literature will be briefly reviewed....
Treatment Recommendations
As with monoinfected patients, those with dual HBV/HCV infection being considered for treatment should undergo laboratory testing, including serum HBV DNA and HCV RNA levels, HCV genotype, HBeAg, anti-HBe, as well as hematologic and liver function studies. Testing should also be performed to exclude other parenterally transmitted viruses such as hepatitis delta virus and the HIV.
Determining the optimal treatment strategy requires an assessment of the "dominant" hepatotropic virus (Table 2). Patients should be considered for therapy if they meet the inclusion criteria of established guidelines for treatment of either HBV or HCV monoinfection. In patients with HCV-dominant disease, peginterferon plus ribavirin would be the best choice of therapy given the experience with peginterferon in hepatitis C patients and the published studies of interferon plus ribavirin in the coinfected population. In patients with active HBV disease, interferon or peginterferon alone or with lamivudine should be considered. Additional studies are required before adefovir or entecavir can be recommended in this patient population, but regimens containing these agents may be useful on a case-by-case basis in patients with HBV-dominant disease. Referral to a transplant center is indicated for coinfected patients with fulminant hepatitis, decompensated cirrhosis, or HCC who are appropriate candidates for transplantation."
http://www.clinicaloptions.com/Hepatitis/Resources/News%20and%20Comment/Expert%20Viewpoints/July-August%202005.aspx
"Coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is not uncommon, particularly because of similar routes of infection. In HBV-infected patients, the rate of HCV coinfection ranges from 10% to 30%.[1]
Patients who are coinfected have various serologic and virologic profiles and a diverse spectrum of disease. Dual infection with HBV and HCV is associated with more advanced liver disease and an increased risk of hepatocellular carcinoma (HCC), making consideration of treatment for such patients a priority.[2,3] Treatment of coinfected patients is challenging and has not been well studied. The limited published literature will be briefly reviewed....
Treatment Recommendations
As with monoinfected patients, those with dual HBV/HCV infection being considered for treatment should undergo laboratory testing, including serum HBV DNA and HCV RNA levels, HCV genotype, HBeAg, anti-HBe, as well as hematologic and liver function studies. Testing should also be performed to exclude other parenterally transmitted viruses such as hepatitis delta virus and the HIV.
Determining the optimal treatment strategy requires an assessment of the "dominant" hepatotropic virus (Table 2). Patients should be considered for therapy if they meet the inclusion criteria of established guidelines for treatment of either HBV or HCV monoinfection. In patients with HCV-dominant disease, peginterferon plus ribavirin would be the best choice of therapy given the experience with peginterferon in hepatitis C patients and the published studies of interferon plus ribavirin in the coinfected population. In patients with active HBV disease, interferon or peginterferon alone or with lamivudine should be considered. Additional studies are required before adefovir or entecavir can be recommended in this patient population, but regimens containing these agents may be useful on a case-by-case basis in patients with HBV-dominant disease. Referral to a transplant center is indicated for coinfected patients with fulminant hepatitis, decompensated cirrhosis, or HCC who are appropriate candidates for transplantation."
http://www.clinicaloptions.com/Hepatitis/Resources/News%20and%20Comment/Expert%20Viewpoints/July-August%202005.aspx
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