Sofosbuvir / Ledipasvir for type 1a

[LeelaLo]

Hi there!

I'm looking for more info about the new orals for HCV 1a, hope that so one here might help! My Doc says that previous treatment MAY build up some resistance to re treatment, making outcome less certain. I notice that the Gilead trials did include treatment experienced people, including with 'protease inhibitors' (incivek / telaprivir?) and that they were on the whole equally successful. So I'm wondering if anyone has achieved SVR with this new combo after having relapsed after previous triple therapy with the Incivek/telaprivir, Rib and Interferon?!

Any feedback would be GREATLY appreciated, as I am struggling so much with this triple therapy that I'm very very close to throwing in the towel, hoping that all is not lost with the newbies on the horizon!

Thanks in advance

LeelaLo x

[johnny679]

Sofosbuvir and Ledipasvir will be approved by pbs in Australia around 2018 . These are the words of 2 very good hepatolist .

[Pamelajean1]

Thank you ms Maddie!
And continued success on your journey to a CURE....you're almost there!

[ms maddie]

I think having it handled by Health Advocate will be very helpful.  They will now the ins and outs of the appeal process.  I pray you will get your approval very soon.  Good Luck!

[Pamelajean1]

I was hoping to be right behind you in treating....unfortunately I'm on my 2nd appeal with insurance. Very disappointing.
I do have a third party Health Advocate involved with this appeal though so I remain somewhat hopeful.

Thanks for thinking of me.

[ms maddie]

Did you ever start on the Sovaldi/Ollysio combo?  I thought you were looking into it.  I did start it about a month ago.

[Pamelajean1]

I wanted to find some evidence that if I fail with Sovaldi/Olysio that it wouldn't keep me from retreating with Sovaldi/Ledi....if I'm reading this right, it seems I can!  Since Olysio is a protease inhibitor....

About the ION Studies....Sovaldi/Ledi

"The Phase 3 ION studies are randomized, open-label Phase 3 clinical trials evaluating the efficacy and safety of a once-daily fixed-dose combination of SOF/LDV for 8, 12 or 24 weeks, with and without RBV, among 1,952 genotype 1 HCV patients. The studies included patients who were treatment-naïve or who had ***failed previous treatment, including protease inhibitor-based regimens.*** The primary endpoint for each study was SVR12. Complete results from all three studies will be presented at a future scientific conference.

The ION-2 study evaluated 440 treatment-experienced genotype 1 HCV patients who had failed past therapy with regimens containing Peg-IFN (including Peg-IFN ***plus a protease inhibitor***). Patients received SOF/LDV with or without RBV for 12 or 24 weeks."

My hep doc has told me I could retreat with Sofo/Ledi if I fail with Sofo/Olysio and I personally know of people that are treating successfully with Sofo /Olysio that failed with incivek/interferon/RIBA.

Hope that helps!

[asle]

Just a note, once you have taken one of the PI's, (Boceprevir & Telaprevir), you can't take that again.
The combo offered at the moment is one of the new drugs/Riba/Interferon for 12 or 24 weeks.

[asle]

Hi there.
I live in Australia and am finding it hard to find out information about what new drugs are available for Genotype 1, and what combinations are available here. I have an appointment with someone tomorrow, and I will ask them about this.

There are hundreds and hundreds of people that have been part of MedHelp and have treated successfully with the triple therapy you are currently on. They don't all post in the forum when they reach SVR, and so you are reading posts on the Post Treatment site that only people with lingering issues post. Take this into consideration. Also, most people join this forum because they have side effects and need advice etc. So, you may not hear from people who are treating without too much problem.
Perhaps some of the people who have reached SVR on this treatment will jump in and reassure you.

I noticed that you were Undetected at 12 weeks. Were you still Detected at 4 and 8 weeks? What was your log drop at 4 or 8 weeks when you had your HCV PCR?
Triple therapy can be harsh. I had a lot of side effects, and had blood transfusions, reduced Ribavirin, you name it.
What is happening that makes you want to throw in the towel?
And what does your GI think? Do you trust your medical team?
If you stay undetected, and can do the next 4 months, I would stay on treatment.
If you stop, you will have to wait at least a year to go on treatment again, as you will have to clear the other drugs out of your system, and wait til we know what combo will be available for GT1.
You will also have to take a combo that may include one of the new drugs with Interferon and or/Ribavirin anyway.
The new drugs, Sofosbuvir and Ledipasvir have not yet been approved by the PBS, so cost is a problem.
Perhaps if you can answer some of these questions and I can/or others will, get back to you.