i am a non responder,after 2 previous tratments with other interferons,now after having a liver biopsy my dr wants me to go on pegasys with copegus, he wants to prescribe the 180mcg/0.5ml shot along which is prefilled but he wants me to take some of the other prefilled shot which would make it more than the normal 180 mcg. i did not ask him exactly how much it will total cause i have doubts about this,i have never heard of this. and may just stick with the 180 once a week.i was also prescribed 1200 mg of copegus, if THE 180 pegasys is increased won't i have to take a higher dose of copegus ? i haven't started the treatment yet,even though i have the meds at home, this sounds kind of strange to me !