You guys remind me of the 70s, when my friends and I would be tripping on acid and discussing all the mysteries of the universe. But now you guys drug of choice is peg/riba combo cocktail. lol Peace
Yeah, right. LOL. They always throw in that "regression anlaysis" stuff. But basically, being male is an indpendent negative *pre-tx* predictor for SVR, but my understanding from talks with those supposedly in the know is that it gets overriden once treatment starts with *during-tx* predictors such as the week 4 PCR. In other words, if being male in your case was such a negative predictor -- or your stage 3? damage for that matter -- then you probably never would have cleared at week 4. See???
I'm in a bit of a fog now -- so what follows is at your own risk LOL -- you're a geno 2 or 3 right who cleared at week 4. Standard tx is 24 weeks but you could conceivably treat-short course for 12 weeks or 16 weeks depending on whether you're on Peg intron or Pegasys.
But you're a stage 3? You're male? And you have a good sense of humor? OK. Putting all that in my regression equataion :) I could understand forgoing the short course and making yourself sick for 24 weeks while you entertain us with your woes. However, why the 48 weeks given being non-detecible at week 4? I'm sure the tomatoes in your fridge will be very happy with any leftover Procrit.:)My guess is your SVR stats will not change whether you treat for 12, 24 or 48 weeks. If you relapse (unlikely) you're gonna relapse but it will be for reasons other than treatment length. You kmow, sunspots hasn't been discussed a lot around here but personally that's how I decided to when to begin and end tx. :)
-- Jim
Sad to say, but I never had much of an attention span for math. Can anyone help me interpret the following from an abstract on predictors of SVR failures in genos 2 & 3? I know Cougar... I should just settle in for the ride, but where's the anxiety in that? I'm engaged in psychological warfare aagainst the bugs, and I want them scared :) And, I actually want to understand the benefit in going 48 wks vs. 24.
From the abstract.........
The Method:
Identification of variables associated with treatment failure was done by comparing variables of interest between SVR and non-SVR groups using Wilcoxon test for continuous variables and Chi-Square for categorical variables. Individual logistic regression was done to obtain Odds Ratios (OR). Multivariate modeling was done to identify independent predictors of treatment failure.
Sample Results:
...Male gender (p=0.01, OR=6.2, 95% CI 1.5-43.3),.....
Given the above sample result (one of several), how does one interpret the negative impact of being male on the likelyhood of SVR? The abstract: http://www.hcvadvocate.org/news/reports/DDW_2005/May%2015%20HCV.htm
hello again and thanks for support. I was wondering if anyone knows of a good book for pregnant with hep c because, although i have almost every book out there on hep c i have not found anything substantial on the subject. Only the warnings on low iron intake or all other warnings but no real good suggestions... My doctor here does not seem to be very savvy on hep c as I have a feeling i am his first pregnant patient with hepc. I will be calling my doc in Europe tonight but i just wondered if anyone here has any suggestions. I have had 2 biopies already and i know my liver is in good condition..no cysts or lesions on the surface and the levels seem to stay pretty good all the time. My concern is the change over now. That i am not sure how to handle. Thank you.
Goof prev: "In the Italian study, on which I seem fixated"
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If you find yourself handing out canoli's at halloween, then maybe it's time to start reading the German study :)
Hey goof what did you do to the thread below, I couldn't post a comment. Are you sure you're allowed to play on the computer.
Jim, can't help you; I go into riba-rage when my girlfriend ask me what I want for dinner. Can't make any decisions and it's starting to get a little difficult to communicate.
Friole they sell sharps containers at the pharmacy retail. Where I live your doctor or the pharmacy will take the full ones.
Peace