does anyone know

[cooderbrown]

I started sovaldi, ribavirin, and pegasys on April 12, Iam geno type 1b, at 4 wk viral load Iam undetected what are my chances of svr

[nan535]

Great news, Hector!  Keep the faith...

Nan

[cooderbrown]

I thought the same same thing july 4  I hope this is a good sign , especially after failing 2 previous times. I will remain positive and keep watching my diet. HOW ARE YOU DOING?

[flyinlynn]

Good luck cooderbrown

Good day to complete treatment 4th of July freedom day!

Best to ya
Lynn

[cooderbrown]

had my 8 week viral load still not detected, geno type 1b, on sovaldi, pegasys, and ribavirin, will finish treatment july 4, will get another viral loa done then. then 3 months after EOT hope it stays gone holding my breath!!!!!

[cooderbrown]

hi Hector 70% is a lot better than my two previous treatments of only 30% I have hope and will never give up thanks

[cooderbrown]

thanks for the great reply I really needed that Love to all

[cooderbrown]

thanks for the positive feed back, I pray for you and others everyday ,we will beat this

[cooderbrown]

thanks for the positive encouragement I to failed twice with the old treatments 3rd times a charm I will remain positive thanks to people like you God Bless

[can-do-man]

Cooder, just wanted to make it clear your odds are much better now then when those of us treated with just the old SOC. My first treatment my odds was at the most 30% and that was doing a 72 week course. The most important thing in my opinion is keep taking all your meds for the full course and don't let any hype get in the way. Then your odds are very much on your side. Best to you.
-----------------------

Hector, you couldn't ask for a better team and Hospital. Plus you fully understand these things. If one has a TP there's never been better meds to cure those then what is coming out. You will soon be joining Mikesimon and OH and a few others that have been here that are now Hep free and out raising h*ll...:)

As for people being a donor, I can't think of a better way to leave this life then by giving others and their family that kind of gift. They are my hero.

Fine here thank you.
Can-do

[HectorSF]

Hi.

Yeah so much misinformation about the new treatments if post in this forum no wonder so many people are confused. Lots of SVR numbers that have nothing to do with the poster's hep C treatment naive or not, IL28B, 1a or 1b, stage of liver disease and the particular treatment they are on. These things do matter according to SVR rates in the trials. I tried to explained all of this basics of the new treatments in another post.

I guess no one read it or believed it. Oh well...
------------------------------------------------------------------------------------------------------
Hey, I am 7 months post LT (liver transplant as they say in the med journals) in about a week, the 16th. No new cancer at 6 month scan. So thankful. Still high risk but still beating the odds (knock on my lower right rib cage). A few bumps in the road with my immunosuppression meds and a recent foot infection but all and all a friggin' atheist miracle! haha My 36 year old female liver is treating me very well. She is also keeping my hep C at bay. Normal ALT and AST levels. I will be talking to Dr. Terrualt in a week or so and we will devise a plan (the nuclear option?) to kill off this persistent bugger once and for all. Maybe treat next year? We'll see.
Hope you are well!
Hector

[Auds52]

Your outcome looks positive . Nothing to it isn't really how i view my treatment my life has been turned upside down i barely have a day when i.m ok but i.ll keep going because my aim is to get my life back x

[flyinlynn]

Hi Can-do

I made the mistaken assumption the OP was treatment naive. I neglected to check for prior posts or info on coderbrowns profile.

I just wanted to get something out there to refine the comment of "Nothing to it, just get a viral load test every 4 to 6 months!
You're fine." I just didn't want to leave that hanging.

I guess cut and past on a cell phone has some limitations.

Thanks for clarifying my comments with a more thorough and complete answer Hector.

Best wishes to all
Lynn

[can-do-man]

Thanks Hector... People need to research and understand these results before passing out info. also the OP IS a prior treatment failure.

[HectorSF]

Right. And these figures are only for the treatment naive.

Also for genotype 1b the correct line is "Genotype 1b 82% (54/66) ".
The first 1b is a reference to note b. below the figures.

The last few sentences were cut off. It should read.

"It is estimated that the response rate in patients who previously failed pegylated interferon and ribavirin therapy will approximate the observed response rate in NEUTRINO subjects with multiple baseline factors traditionally associated with a lower response to interferon-based treatment (Table 9). The SVR rate in the NEUTRINO trial in genotype 1 subjects with IL28B non-C/C alleles, HCV RNA >800,000 IU/mL and Metavir F3/F4 fibrosis was 71% (37/52)."

NOTE: All candidates that treated became undetectable. They always do on Sovaldi based treatments. "On-treatment virologic failure
0/327 " All people that fail treatment do so after stopping treatment. "Relapse". No one doesn't become undetectable and there are no breakthroughs during treatment so the only way to fail treatment is to relapse as noted in trial data.

Hector

[flyinlynn]

Table 8 Response Rates in Study NEUTRINO
SOVALDI + Peg-IFN alfa + RBV 12 weeks
N=327a
Overall SVR
90% (295/327)
Genotype 1b
89% (261/292)
Genotype 1a
92% (206/225)
Genotype 1b
82% (54/66)
Genotype 4
96% (27/28)
Outcome for subjects without SVR
On-treatment virologic failure
0/327
Relapsec
9% (28/326)
Otherd
1% (4/327)
a. Including seven subjects with genotype 5 or 6 infection.
b. One subject had genotype 1a/1b mixed infection.
c. The denominator for relapse is the number of subjects with HCV RNA 800,000 IU/mL
71% (37/52)
SVR rates were 98% (93/95) in subjects with baseline IL28B C/C allele and 87% (202/232) in subjects with baseline IL28B non-C/C alleles.
It is estimated that the response rate in patients who previously failed pegylated interferon and ribavirin therapy will approximate the observed response rate in NEUTRINO subjects with multiple baseline factors traditionally associated with a lower response to interferon-based treatment (Table 9). The SVR rate in the NEUTRINO trial

[SimpleMan1959]

Nothing to it, just get a viral load test every 4 to 6 months!
You're fine.