Aa
tylenols real history
things your mama never told you.....
Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure.Flaks B, Flaks A, Shaw AP.
Groups of male and female inbred Leeds strain rats were fed diets containing either 0.5% or 1.0% paracetamol by weight for up to 18 months. At the 1.0% dosage level, 20% of rats of both sexes developed neoplastic nodules of the liver, a statistically significant incidence. These rats also showed gross enlargement of their livers and an increase in foci of cellular alteration, the latter also being observed in the low dosage male rats. Papillomas of the transitional epithelium of the bladder developed in all paracetamol-treated groups, and three rats bore bladder carcinomas. However, significant yields of bladder tumours were only obtained from low dosage females and high dosage males. Additionally, 20 to 25% of paracetamol-treated rats developed hyperplasia of the bladder epithelium, which was not coincident with the presence of bladder calculi. A low yield of tumours at various other sites also arose following paracetamol feeding. An electron microscope study of the livers of paracetamol-treated rats revealed ultrastructural changes in the hepatocytes that resemble those that result from exposure to a variety of known hepatocarcinogens.
Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure.Flaks B, Flaks A, Shaw AP.
Groups of male and female inbred Leeds strain rats were fed diets containing either 0.5% or 1.0% paracetamol by weight for up to 18 months. At the 1.0% dosage level, 20% of rats of both sexes developed neoplastic nodules of the liver, a statistically significant incidence. These rats also showed gross enlargement of their livers and an increase in foci of cellular alteration, the latter also being observed in the low dosage male rats. Papillomas of the transitional epithelium of the bladder developed in all paracetamol-treated groups, and three rats bore bladder carcinomas. However, significant yields of bladder tumours were only obtained from low dosage females and high dosage males. Additionally, 20 to 25% of paracetamol-treated rats developed hyperplasia of the bladder epithelium, which was not coincident with the presence of bladder calculi. A low yield of tumours at various other sites also arose following paracetamol feeding. An electron microscope study of the livers of paracetamol-treated rats revealed ultrastructural changes in the hepatocytes that resemble those that result from exposure to a variety of known hepatocarcinogens.
Hahahaha.. I remember that song. As a matter of fact, I went to high school in Akron. OH with one of the writers (Jerry Buckner). A really bad way to mark your success. Hahahahah....
Magnum
Magnum
The quote was from Mary B's posting above but is consistent with everything I've read in the last five years.
http://74.125.93.132/search?q=cache:W_ss1ix2X20J:www.faetc.org/Hepatitis/Patient/Hepatitis_C_Patient_Education_Slides.ppt+CDC+tylenol+dosage+with+HCV&cd=10&hl=en&ct=clnk&gl=us
I've heard of some doctors willing to go as high as 3000 mg/day but that's the exception rather than the rule. My understanding is no more than 1000 mg/day with cirrhosis.
http://74.125.93.132/search?q=cache:W_ss1ix2X20J:www.faetc.org/Hepatitis/Patient/Hepatitis_C_Patient_Education_Slides.ppt+CDC+tylenol+dosage+with+HCV&cd=10&hl=en&ct=clnk&gl=us
I've heard of some doctors willing to go as high as 3000 mg/day but that's the exception rather than the rule. My understanding is no more than 1000 mg/day with cirrhosis.
Ddn't one of the mice wear tweed (the "control" mouse)? If I remember right the "control" mouse got less cancer and more women.
Thanks for the memories!
jd
Thanks for the memories!
jd
"the new ASSLD recommendation is no more that 2 grams period per day for liver patients and this only if in stage 1 or 2."
If you have no worse than mild to moderate fibrosis and your pain can be controlled with no more than 4 tablets in a 24 hour period, go for it. It's not rocket science.
If you have no worse than mild to moderate fibrosis and your pain can be controlled with no more than 4 tablets in a 24 hour period, go for it. It's not rocket science.
An article on acetominophen that talks about it in general and then specifically for persons with Hep C:
http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Acetominophen.pdf
Excerpts from that article:
Acetaminophen for People with Hepatitis
What does all this mean for people with chronic hepatitis
B or C? Doctors often recommend acetaminophen to
relieve symptoms such as body aches and fever, which are
common side effects of interferon therapy. For most people,
acetaminophen is safe and effective. According to the FDA’s
Dr. John Senior, “It’s very clear the average dose for the
average person is very safe. But we are not all average
people.” For many individuals, acetaminophen is still a good
choice, especially considering that other over-the-counter
pain-relievers can cause problems of their own (such
as stomach bleeding with aspirin and nonsteroidal antiinflammatory
drugs).
Many HCV providers now recommend that their patients
with HCV take a somewhat lower dose than is generally
recommended for people with healthy livers. It is also
important that medical providers know what medications
their patients are using (including over-the-counter and
prescription medications) so that the medical provider
can best advise a person with hepatitis C on how much
acetaminophen is safe.
The following tips can help prevent acetaminophen-related
liver toxicity:
• Do not take more than the recommended dose of 4 grams
within a 24-hour period (for example, 12 regular strength or 8
extra strength Tylenol tablets)
• Do not take the full day’s dose at one time; space it out over
the course of the day
• Do not take acetaminophen for more than 10 days in a row
• Avoid drinking alcohol; this is important for people with
hepatitis whether or not they use acetaminophen
• People who do consume 2-3 alcoholic drinks per day
should not take more than half the usual recommended dose
of acetaminophen (2 grams within 24 hours)
• People with advanced liver fibrosis or cirrhosis should avoid
acetaminophen
• Write down how much acetaminophen you take, and when,
if you have trouble remembering
• Check the labels of all medications; small doses of
acetaminophen in combination remedies can add up to big
trouble.
http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Acetominophen.pdf
Excerpts from that article:
Acetaminophen for People with Hepatitis
What does all this mean for people with chronic hepatitis
B or C? Doctors often recommend acetaminophen to
relieve symptoms such as body aches and fever, which are
common side effects of interferon therapy. For most people,
acetaminophen is safe and effective. According to the FDA’s
Dr. John Senior, “It’s very clear the average dose for the
average person is very safe. But we are not all average
people.” For many individuals, acetaminophen is still a good
choice, especially considering that other over-the-counter
pain-relievers can cause problems of their own (such
as stomach bleeding with aspirin and nonsteroidal antiinflammatory
drugs).
Many HCV providers now recommend that their patients
with HCV take a somewhat lower dose than is generally
recommended for people with healthy livers. It is also
important that medical providers know what medications
their patients are using (including over-the-counter and
prescription medications) so that the medical provider
can best advise a person with hepatitis C on how much
acetaminophen is safe.
The following tips can help prevent acetaminophen-related
liver toxicity:
• Do not take more than the recommended dose of 4 grams
within a 24-hour period (for example, 12 regular strength or 8
extra strength Tylenol tablets)
• Do not take the full day’s dose at one time; space it out over
the course of the day
• Do not take acetaminophen for more than 10 days in a row
• Avoid drinking alcohol; this is important for people with
hepatitis whether or not they use acetaminophen
• People who do consume 2-3 alcoholic drinks per day
should not take more than half the usual recommended dose
of acetaminophen (2 grams within 24 hours)
• People with advanced liver fibrosis or cirrhosis should avoid
acetaminophen
• Write down how much acetaminophen you take, and when,
if you have trouble remembering
• Check the labels of all medications; small doses of
acetaminophen in combination remedies can add up to big
trouble.
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