viral load <15 at week 2

[TIMBOY67]

week 2 blood OF 16 week sof/rib trial results returned . VL <15 .is this still a good predictor for svr ?

[hepcat1954]

You are responding well to the Tx!  Stay the course!

Good luck to you!
HC
...

[TIMBOY67]

thanks hc ,

My baseline was 3.5 million week1  530 , week2  <15 ,
Im on gilead sof/rib 16 weeks .

Staying positive , so far no sides , feeling good & hoping for the best
result in svr

Prev non resp int/rib , gen 3 , non cirhotic , .

T.B.

[hepcat1954]

What was your initial VL?  What trial are you on?

I was on a Sofosbuvir + Ledipasvir trial for 12 weeks.  Initial VL 550,000.  Week 1 VL < 15 IU/mL.  Week 2 VL UND.  I have been UND ever since.

I've heard of many trial participants who were < 15 IU/mL at Week 2 and who then became UND at Week 4 and have stayed that way.  Keep steady with your trial.

Best predictor of SVR is UND at EOT (End of Trial) and UND at PT (Post Trial) Week 24.  (Being SVR24 is best predictor of permanent cure!)

Good luck,
HC
...

[HectorSF]

Hi Tim,

While previous studies with peg-interferon (PegIFN) based therapy demonstrated that early viral kinetics could help to predict SVR rates this is not the case with Sovaldi + Ribavirin treatment.

Treatment with non-interferon based treatments work differently than previous interferon based treatments so what applied to interferon based treatments RVR, eRVR, EVR are no longer applicable. In other words...
early viral kinetics with Sovaldi/sofosbuvir based treatment is no predictor of treatment success.

Almost all patients achieve UND by week 4 (95%+). Once undetectable no one ever has a breakthrough while on Sovaldi. Again this is different than with interferon based treatment. Because Sovaldi has a high barrier to resistance. So the only way patients fail treatment is by having a Relapse after they stop treatment. This usually occurs within the first month after stopping treatment.

Predictors for success with Sovaldi/sofosbuvir + RBV based treatments include genotype, previous treatment experience, cirrhosis or not, treatment duration etc.

So to sum up...Can we predict relapse with early viral kinetics with Sovaldi/sofosbuvir + Ribavirin based regimen?
No.

Good luck with your treatment!
Hector