I'm 1A with beginning VL of 1.5M and mild fibrosis based on biopsy. My doctor has me on one a week of interferon (pegasys) and 1200ml of riba per day. I cleared in 13 weeks. I wouldn't care to face the needle every night but I am a sissy at times. Don't know why he would go the once a day option versus once a week. Must be a reason maybe it isn't as hard on your system one way or the other. Could be other medical conditions involved. I hope you do well no matter which way you go. Dale