Aa
when taking incivek and anal burning
occurs...is this an indication that all of the incivek is not being absorbed..some being passed out causing burning and other issues....for myself the burning was there in the first few weeks...as my hgb dropped and other sx came out the burning went away...is that because my body was taking in more of the incivek..passing out less incivek reducing anal burning??...for folks that get anal burning is that a sign...a sign that they aren't taking in the incivek properly....or taking in too much and they should reduce the incivek? just wondering if anyone has thought about this.....billy
Been on encivek four weeks, it is a *****. I tried everything to calm it down. I described it to my wife like I was ******** out a cactus. Hot showers, I would lay in tub let water run over me. Dr. Prescribed lidocaine, it burns like hell when applied, but slowly numbs it.
I hate to admit it but I want to the street and got myself percocets to deal with pain. I will continue to do this until the encivek cycle is over.
I hate to admit it but I want to the street and got myself percocets to deal with pain. I will continue to do this until the encivek cycle is over.
I don't know about everyone else but my a**hole burns like a mutha and brings me to tears. The Dr precribed a cortizone procto cream - not much help. Tucks was like pouring acid on a road burn! I religiously take the 20 grms of FAT and am gaining weight accordingly. I try to drink 64 ounces of water I know I drink it all night long and pee accordingly every 2 hours. Also it takes a good hour for my hands to warm up. I live in snow country but this is a different coldness. Numbing of the balls of my feet not a sore big toe - so who the hell knows - i am sure in about 5 years we will see incivek listed on one of those 2AM TV lawyer ads asking us if our assholes fell out as a result of taking incivek back when.... if so... we could be due a lot of money in some scamming lawsuit (that is.... if we are still alive) HA! coming up on do or die week 12 - we shall see . . . .
i don't just reduce my dose.....there are plenty of folks that only had anal burning for a few weeks...not just me......and yes i don't want to take any more drugs then i need to...thats just the way i am...i never have...i also am not trying to give advice...just trying to help figure out this hep c...and no one would or wanted to give an opinion on if the anal burning stopped while taking incivek this was an indication of how well the incivek was being absorbed....sorry guys...maybe i'm wrong on this...billy
Sometimes I wish this was like facebook and I could hit the like button ;)
I dont think anyone on here is sarcastic or mean, just honest.
I dont think anyone on here is sarcastic or mean, just honest.
No one is being unkind. They're trying to keep people out of trouble because of misinformation. The greatest injustice one can do to another is to misinform which may ultimately jeopardize treatment results. We're not talking about holding hands and guiding someone through a rough time here. Working dog does not read enough about the PI's to speak intelligently - he only knows his experience and it does not translate to treatment success.
calm down,,,, in Rodney Kings words " cant we all just get along", it hurts when peeps are sarcastic we have all been through a lot and I think most of us want to help each other.. lets try to be kind in our words.
Mary
Mary
..is that because my body was taking in more of the incivek..passing out less incivek reducing anal burning
IMO I think your worried about stopping early and looking for some sort of justification to make yourself feel better about it, that some how you managed to absorb the incivek better than everyone else so it must be ok that I stopped early. Wrong answer.
IMO I think your worried about stopping early and looking for some sort of justification to make yourself feel better about it, that some how you managed to absorb the incivek better than everyone else so it must be ok that I stopped early. Wrong answer.
Try not to over-think this. Incivek is new. None of us is equipped with enough information to alter the dose. Your doctor is the only person who should prescribe drugs or recommend doses of any drug.
Its a bad idea to take meds other than exactly as prescribed.
Its a bad idea to take meds other than exactly as prescribed.
I got the question and I answered it accordingly. The gist is people with anal problems are absorbing Incivek just fine. Do you actually think it's prudent to say because you only had those issues for several weeks means you were absorbing it more efficiently? Seems to me if that were the case you would have been UND at 4 weeks and you were not. I had anal issues the entire 12 weeks, and I was UND at 4 weeks. I don't see where your initial post was helpful at all and you are no authority on what has been tested or needs to be tested so indicating people are taking in too much Incivek and they should reduce they should reduce the dosage irresponsible. You are not a chemist or medical researcher and should leave dosing recommendations to the experts including ribavirin and interferon.
dog,
I think your question was understood and I personally don't know the answer to it --- I am not even taking Incevik. Perhaps someone will do a study on burning vs absorption, but I rather doubt it. The issue I had was with this statement:
"...for folks that get anal burning is that a sign...a sign that they aren't taking in the incivek properly....or taking in too much and they should reduce the incivek?"
You are making the suggestion that there should be a reduction in the dose. You are correct that there is not enough information out there now. Will they do weight based INC later? I kind of doubt it, but we shall see.
I think your question was understood and I personally don't know the answer to it --- I am not even taking Incevik. Perhaps someone will do a study on burning vs absorption, but I rather doubt it. The issue I had was with this statement:
"...for folks that get anal burning is that a sign...a sign that they aren't taking in the incivek properly....or taking in too much and they should reduce the incivek?"
You are making the suggestion that there should be a reduction in the dose. You are correct that there is not enough information out there now. Will they do weight based INC later? I kind of doubt it, but we shall see.
first i don't think anyone got this question...i never missed buy more then one hour on my incivek...and never missed in my interferon...i just stopped the incivek 5 days early....and have been on 1200 riba most of tx....the question was.... if someone has anal burning is that because the incivek is some of theincivek getting passed out of there systems....i've been reading about folks here that the anal burning lasts for many weeks....mine only lasted the first few weeks then stopped and other sx got way worse...so maybe i absorbed more of the incivek then folks that have the anal burning for more weeks...i think in the near future there will be much more info coming out on drug doses as they will not just go by weight for dose...the more we all keep each other informed on not only whats been tested but also needs to be tested or looked at the better for future folks....not me...i'm just trying to help....soon i'll be busy and may not have time to help much......billy
working dog
You sure do try to come up with reasons to self-administer the Incevik. I am glad jbugu had information on hand to dispell this. It is a bad idea to give people the idea that the amount of Incevik is up to them. IT works because it is taken per the label. You stopped early, and that may end up being okay, but let's not tell everyone else to do the same or change doses because of side effects.
I forgot a riba on Monday morning and did not realize it until Monday evening's dose. I just could not find it in me to flat out skip it so I spread the missing dose over 3 days. I don't know, dog, but to me, being successful is much more important that my inconvenience. I could have told myself that if I just skipped it , it would help my anemia, but I really want to clear this virus once and for all and not have to do this a third time.
frijole
You sure do try to come up with reasons to self-administer the Incevik. I am glad jbugu had information on hand to dispell this. It is a bad idea to give people the idea that the amount of Incevik is up to them. IT works because it is taken per the label. You stopped early, and that may end up being okay, but let's not tell everyone else to do the same or change doses because of side effects.
I forgot a riba on Monday morning and did not realize it until Monday evening's dose. I just could not find it in me to flat out skip it so I spread the missing dose over 3 days. I don't know, dog, but to me, being successful is much more important that my inconvenience. I could have told myself that if I just skipped it , it would help my anemia, but I really want to clear this virus once and for all and not have to do this a third time.
frijole
I whole heartedly agree with jbugu. The thought of people messing with their Incivek dosage, potentially not being successful and as a result being left with long term resistance is not to be taken lightly. Even more reason for people to treat with a doctor who fully understands the implications of not following the regiment correctly.
-Dave
-Dave
Perhaps if you researched the Incivek prescribing guidelines you would know exactly what happens during the Incivek process. Anal issues are a very good indication the Incivek is being absorbed properly and eliminated properly. Incivek isn't like ribavirin, you can't reduce it because you're having issues.
Anorectal Signs and Symptoms
In the controlled clinical trials, 29% of subjects treated with INCIVEK combination treatment experienced anorectal adverse events, compared to 7% of those treated with peginterferon alfa and ribavirin alone. The majority of these events (e.g., hemorrhoids, anorectal discomfort, anal pruritus, and rectal burning) were mild to moderate in severity; less than 1% led to treatment discontinuation and all resolved during or after completion of INCIVEK dosing.
Elimination
Following administration of a single oral dose of 750 mg 14C-telaprevir in healthy subjects, 90% of total radioactivity was recovered in feces, urine and expired air within 96 hours post-dose. The median recovery of the administered radioactive dose was approximately 82% in the feces, 9% in exhaled air and 1% in urine. The contribution of unchanged 14C-telaprevir and the R-diastereomer of telaprevir towards total radioactivity recovered in feces was 31.9% and 18.8%, respectively. After oral administration, the apparent total clearance (Cl/F) was estimated to be 32.4 L/h with an inter-individual variability of 27.2%. The mean elimination half-life after single-dose oral administration of telaprevir 750 mg typically ranged from about 4.0 to 4.7 hours. At steady state, the effective half-life is about 9 to 11 hours.
Dose Reduction
To prevent treatment failure, the dose of INCIVEK must not be reduced or interrupted. Refer to the respective prescribing information for dose modification of peginterferon alfa and ribavirin [see Warnings and Precautions (5.7)].
Anorectal Signs and Symptoms
In the controlled clinical trials, 29% of subjects treated with INCIVEK combination treatment experienced anorectal adverse events, compared to 7% of those treated with peginterferon alfa and ribavirin alone. The majority of these events (e.g., hemorrhoids, anorectal discomfort, anal pruritus, and rectal burning) were mild to moderate in severity; less than 1% led to treatment discontinuation and all resolved during or after completion of INCIVEK dosing.
Elimination
Following administration of a single oral dose of 750 mg 14C-telaprevir in healthy subjects, 90% of total radioactivity was recovered in feces, urine and expired air within 96 hours post-dose. The median recovery of the administered radioactive dose was approximately 82% in the feces, 9% in exhaled air and 1% in urine. The contribution of unchanged 14C-telaprevir and the R-diastereomer of telaprevir towards total radioactivity recovered in feces was 31.9% and 18.8%, respectively. After oral administration, the apparent total clearance (Cl/F) was estimated to be 32.4 L/h with an inter-individual variability of 27.2%. The mean elimination half-life after single-dose oral administration of telaprevir 750 mg typically ranged from about 4.0 to 4.7 hours. At steady state, the effective half-life is about 9 to 11 hours.
Dose Reduction
To prevent treatment failure, the dose of INCIVEK must not be reduced or interrupted. Refer to the respective prescribing information for dose modification of peginterferon alfa and ribavirin [see Warnings and Precautions (5.7)].
My doctor explained to me that it was similar to having the skin rash since there is skin in the immediate area where the anus is (just inside of the hole and I guess before the tissue texture changes). Not a pretty thought....lol.
I personally also thought that things itched and burned a little less when I made a determined effort to drink lots and lots of water.
Once I completed the incivek all of my anal issues disappeared!
I personally also thought that things itched and burned a little less when I made a determined effort to drink lots and lots of water.
Once I completed the incivek all of my anal issues disappeared!
Have an Answer?
You are reading content posted in the Hepatitis C Community
Learn about this treatable virus.
Getting tested for this viral infection.
3 key steps to getting on treatment.
4 steps to getting on therapy.
What you need to know about Hep C drugs.
How the drugs might affect you.
These tips may up your chances of a cure.
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
