Enymes won't go any lower than the 20's

[SunShineGirlie]

I am in week #9 triple therapy Incevik - 4 week PCR Quest <5 8 week PCR Quest <5 (both <43 (undetected called out on test) not  Quest test, RNA test sent to local Hospital) - at 2 weeks it was <43 but showed detected RNA test sent to local Hospital.

My concern has a two question and wondered if anyone has any trial data on this;

1.) My liver enzymes still have not gone below the low 20's.  It is my understanding that the enzyme levels should be in the teens at this point, yes? Now that being said I have fatty liver and that MAY be the cause of the slight elevation, but cannot find any trial data to support that.  Of course my concern is, is this a warning sign of relapse after the treatment is over (I relapsed within 3 months last time after the SOC was complete and my enzymes resembled what they are at this point.

2.) Even though, according to the Vertex protocol it appears I am in line for a shortened treatment time if I remain undetected at weeks 12 and 24.  If you had these enzymes would it influence your treatment time, perhaps a longer duration?

Also - I am a TT - if memory serves that means I am a slow respnder (if at all|) to interferon.  When the Vertex drug was in trial did they do an arm where they did NOT use interferon after the 12 weeks of the PI was met?

Thanks - Sunny

[GoofyDad]

Mine dropped from around 100 to 20's then back up to 40's on TX. No troubles - now SVR and in the teens. It took a few months after tx to get to those levels.

[orphanedhawk]

How I wish my enzymes were even close to the 20s. You are doing great!

[SunShineGirlie]

it is a marker to determine if you would be a good responder to interferon, TT is the least likely to respond - Sunny

[SunShineGirlie]

good luck ginger, can't wait to hear your results - Sunny

[Aquisi]

What's a "TT"? Can't find it on my Acronyms  list. Also CC and CT?
Thanks

[GINGERPAL]

hi sunny.  i am also a TT.  I tried to treat once before with soc, but did not go und at week 12.  
I am now treating with incevik.   On Wed. I had  my 1 wk VL test done.
Keep up the good work...I wish you well.    ginger

[SunShineGirlie]

Hi there!   Nice to meet you :)

Yes, I am a TT 1a relapser.  I am real pleased with my PCR's just concerned about my enzymes.  Maybe I am just being paranoid that it won't work, again.  How are you feeling, do you have any PCR info yet? Sunny

[TripleCrown]

Congrats!!! R u 1a TT? that us a HUGE deal.. Being undetected. Previously our chances were 20% or less on peg/RIBA alone ...
Yeah! I'm so happy for you. And you inspire me to stay the course!!
Week six almost at an end.

[SunShineGirlie]

Hi James, nice to meet you!  Thank you for your input and encouragement - Sunny

[James10500]

That's normal. 0-40ish so this is not an issue. Congrats

[SunShineGirlie]

Hi Anne, thanks for your input!  The Doc told me the enzymes were in the normal range, it is good to know there is another one on here that had similar levels.  I had always read others posts saying they had enzymes in the teens once they cleared the virus.  Have a nice day - Sunny

[Anne1717]

Your liver enzymes are perfectly normal.  Even before I had hep c mine were late teens, early 20's and that is normal.  Other factors affect LFT's as well including fatty liver or certain medications.  I have hypothyroidism which elevates enzymes, osteopenia or osteoporosis would do the same.  I wouldn't worry at all