Aa
More all-oral research .including genotypes 1,2 and 3.
Pharmasett anounces three new Inf. free Phase III trials for all geno types:
http://investor.pharmasset.com/releasedetail.cfm?ReleaseID=619564
http://investor.pharmasset.com/releasedetail.cfm?ReleaseID=619564
As the one in my PSI7977 Cohort who was on RBV and 7977 only (no IFN), and talking with my equivalents in a couple of other cohorts, RBV can make you 'ragey' - one of the other participants nicknames it 'roid-rage'.
Can make life a bit unpleasant for people around you, somewhat mitigated by not wanting to be around them anyhow.
On a side note, I have my SVR36 test on Friday. Cleared my HCV with just RBV and 7977, to SVR24, and they decide they want to extend rechecking out to 48 weeks. Kinda spoiled the party somewhat! Lol!.
(I suspect this is because success rates at 24 weeks were so close to 100%, they wanted to go for gold and see if they'd knocked off the relapsers as well)
Am delighted to see they are moving into Stage III, and also that they are starting trials without even RBV - which will probably truly be virtually side-effect free treatment. I presume(?) that there will be no placebo trial, since they can't offer SOC (incl IFN) as a placebo, and that the entire intake will get treatment. (Which was the case in my Stg-II 7977 trial)
Can make life a bit unpleasant for people around you, somewhat mitigated by not wanting to be around them anyhow.
On a side note, I have my SVR36 test on Friday. Cleared my HCV with just RBV and 7977, to SVR24, and they decide they want to extend rechecking out to 48 weeks. Kinda spoiled the party somewhat! Lol!.
(I suspect this is because success rates at 24 weeks were so close to 100%, they wanted to go for gold and see if they'd knocked off the relapsers as well)
Am delighted to see they are moving into Stage III, and also that they are starting trials without even RBV - which will probably truly be virtually side-effect free treatment. I presume(?) that there will be no placebo trial, since they can't offer SOC (incl IFN) as a placebo, and that the entire intake will get treatment. (Which was the case in my Stg-II 7977 trial)
The next phase of this trial can't come soon enough for me to jump in!!
Glad to hear you are doing well.
Glad to hear you are doing well.
Those that have been on INF and had a bad reaction from it.
They mention in the study outline that there will be legs for "those who can not take ifn." Are these people w/ autoimmune disorders? What else would keep a person from being able to take ifn? Just wondering...
“I don't think we have much experience with Ribaviron when it is not paired with ifn, do we?” Good Point.
“None of us were taking Ribaviron” Was this a Typo? If not, I’m confused about how anyone could have sx from a drug your not taking.
Nevertheless, here are the listed sx from Ribavirin
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000301/#
Ribavirin may cause anemia (condition in which there is a decrease in the number of red blood cells)
Ribavirin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
· cough
· upset stomach
· vomiting
· diarrhea
· constipation
· heartburn
· loss of appetite
· weight loss
· changes in ability to taste food
· dry mouth
· difficulty concentrating
· difficulty falling asleep or staying asleep
· memory loss
· rash
· dry, irritated, or itchy skin
· sweating
· painful or irregular menstruation (period)
· muscle or bone pain
· hair loss
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, or those listed in the IMPORTANT WARNING section, call your doctor immediately:
· hives
· swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
· hoarseness
· difficulty swallowing or breathing
· pain in the stomach or lower back
· bloody diarrhea
· bright red blood in stools
· black, tarry stools
· stomach bloating
· confusion
· dark-colored urine
· yellowing of the skin or eyes
· unusual bleeding or bruising
· vision changes
· fever, chills, and other signs of infection
· depression
· thinking about hurting or killing yourself
· mood changes
· excessive worry
· irritability
· starting to use street drugs or alcohol again if you used these substances in the past
· intolerance to cold
Ribavirin may slow growth and weight gain in children. Talk to your child's doctor about the risks of giving this medication to your child.
Ribavirin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
“None of us were taking Ribaviron” Was this a Typo? If not, I’m confused about how anyone could have sx from a drug your not taking.
Nevertheless, here are the listed sx from Ribavirin
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000301/#
Ribavirin may cause anemia (condition in which there is a decrease in the number of red blood cells)
Ribavirin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
· cough
· upset stomach
· vomiting
· diarrhea
· constipation
· heartburn
· loss of appetite
· weight loss
· changes in ability to taste food
· dry mouth
· difficulty concentrating
· difficulty falling asleep or staying asleep
· memory loss
· rash
· dry, irritated, or itchy skin
· sweating
· painful or irregular menstruation (period)
· muscle or bone pain
· hair loss
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, or those listed in the IMPORTANT WARNING section, call your doctor immediately:
· hives
· swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
· hoarseness
· difficulty swallowing or breathing
· pain in the stomach or lower back
· bloody diarrhea
· bright red blood in stools
· black, tarry stools
· stomach bloating
· confusion
· dark-colored urine
· yellowing of the skin or eyes
· unusual bleeding or bruising
· vision changes
· fever, chills, and other signs of infection
· depression
· thinking about hurting or killing yourself
· mood changes
· excessive worry
· irritability
· starting to use street drugs or alcohol again if you used these substances in the past
· intolerance to cold
Ribavirin may slow growth and weight gain in children. Talk to your child's doctor about the risks of giving this medication to your child.
Ribavirin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
that's so true..my study has a ribavirin arm and when I seemed disappointed to not be in that arm my study coordinator said "Why you want to feel all the side effects that come with the ribaviri?" She then named them and now I am grateful beyond words to so far be having the result I am with no sides..The Quantum study is at my Dr's office and the arms that get the placebo will eventually get the study meds.
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