Welcome to MedHelp --
Very sorry to hear how long you have been suffering -- I can give you a few comments on your data above, but I'm not medically trained, so .... it's just some ideas for you, based on what I've learned from dancing with Lyme.
--spinal taps are currently not viewed by Lyme specialists (LLMDs) as particularly helpful in diagnosing Lyme or in ruling it out, because Lyme does not always present in spinal fluid. I'm not familiar with the test parameters, so can't comment further.
--it's not uncommon for illness or extreme stress to cause a flare up of symptoms, because stress impacts your immune system's ability to hold the Lyme infection in check.
--your 2005 Igenex tests appear quite positive, based on a list of meanings for the various bands on the test, as posted a while back at truthaboutlymedisease [dot] com:
IgG results indicate a more recent infection, and IgM results indicate an older infection, but as long as you have probably had Lyme, this timeline framework is less distinct. I have read and been told that after a long infection, the immune system often doesn't react much at all to show the infection on tests, so any reaction is significant:
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band 30 IND
31 IND = Outer surface protein A (OspA), which shows up ONLY in Lyme
34 ++ = OspB, also shows up ONLY in Lyme
39 + = only shows up in Lyme
41 +
58 IND = may relate to Lyme
66 +
with a Negative IGG result
41 IND = may or may not indicate Lyme
58 IND = may relate to Lyme
66 IND
93 IND = probably Lyme-related
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Overall, tests for lyme are not perfect. They are not yes/no, up/down, red/green -- they are instead 'maybe' and 'middling' indicators that are clues for an experienced doc to read, not an absolute answer. That's why an LLMD is important, because s/he knows that the tests are clues, not answers, and what matters is your history and symptoms, using the tests as data but not conclusions.
Rheumatologists and neurologists are not known for understanding Lyme, and they too often don't take it seriously. If I were you, I would find a Lyme specialist for a work up. It's not too late! If you need help finding a Lyme doc, trying searching online for "LLMD Cleveland" or whatever area you live in. You may have to try several searches to get the right overlap geographically esp if you live near a state line or other boundary.
Let us know how you do, okay? Keep trying -- it's worth it to feel better. Take care --
"IgG results indicate a more recent infection, and IgM results indicate an older infection,"
IgM is the more RECENT infection indicator, and IgG is the OLDER infection indicator, so your results are consistent with having a long-term infection. That was from 2005, tho, and things do change. A longterm infection sometimes doesn't show up much if at all on the tests, because the immune system gives up after a while and doesn't produce the antibodies that the tests measure.
I think of the antibodies as the police, and after patrolling a bad neighborhood for a while and not seeing any criminal activity, the police go somewhere else that needs attention. If however you are given antibiotics, it can stir up your immune system, so the cops come back and your test results may rise.
There is also a PCR test that can be run, that to my understanding looks not for your immune system's reaction to the bacteria, but looks directly for DNA from the bacteria.