Hello!
AKT 4 is same as the present medications, only some dose adjustments. I already confirmed to you that he needs 4 drugs isoniazid, rifampicin, ethambutol and pyrazinamide for 2 months and followed by isoniazid and rifampicin for further 6 months for his Tuberculosis.
Regular follow up and protein diet has already been discussed with you.
Follow your senior physician's advice and believe in his diagnosis and treatment and give some time. If it is tuberculosis it will respond for sure!
Take care!
dear dr vinod
how r u
as advised by u i got the tests repeat on 28 apr i am forwarding you the reports of my son nikhil
before the start of treatment of AKT4, live 52, pyridoxine 10 mg and after 3 weeks of treatment
pls study these reports and give ur valuable advice
reports dtd 06 apr 2010 before AKT4
HAEMATOLOGY
Haematology performed on Fully Automatic 5 part differential COULTER Haematology Analyzer
Investigation Result Unit Reference Range
Haemogram
Haemoglobin. : 13.1 g/dl M : 13 - 18 g/dl
F : 11.5 - 16.5 g/dl
TLC . : 10,600 /c.mm. A : 4000 - 11000 /c.mm.
DLC.
Neutrophils : 68.4 % A : 50 - 80 %
Lymphocytes : 22.1 % A : 25 - 50 %
Monocytes : 7.6 % A : 2 - 10 %
Eosinophils : 1.4 % A : < 6 %
Basophils : 0.5 % A : < 2 %
E.S.R. (Westregen's) : 110 mm/1st Hr F : < 20 mm/1st Hr
M : < 15 mm/1st Hr
R.B.C. Count. : 4.66 mil./cmm M : 4.5 - 6.5 mil./cmm
F : 3.8 - 5.8 mil. /cmm
Packed Cell Volume : 40.2 % M : 40 - 54 %
F : 37 - 47 %
Platelets Count. : 343 thousand/cmm A : 150 - 450 thousand/cmm
M.C.V : 86 fl A : 76 - 96 fl
M.C.H : 28.2 pg. A : 27 - 32 pg.
M.C.H.C : 32.7 % A : 30 - 35 %
RDW : 11.6 % A : 11.6 - 14 %
Peripheral Blood Smear :
RBCs are normocytic normochromic. No significant anisopoikilocytosis is seen.
WBC series is normal in number & distribution. Platelets are adequate. No
haemo-parasite is seen. No abnormal / immature cell is seen
BIO-CHEMISTRY REPORT
Biochemistry tests performed on Fully Automatic ROCHE COBAS 400 INTEGRA & HITACHI 902 / Semi Auto RA-50
/ AVL 9180 / D-10
Investigation Result Unit Reference Range
B. Glucose Fasting. : 78.69 mg/dl A : 70 - 110 mg/dl
Liver Function Test
S. Bilirubin (Total) : 0.32 mg/dL A : < 1 mg/dL
---------------------------------------------------------------------------------------------------
S. Bilirubin (Conjugated) : 0.12 mg/dL A : < 0.6 mg/dL
S. Bilirubin (Unconjugated) : 0.20 mg/dL A : 0.1 - 1 mg/dL
S.G.O.T.(A.S.T) : 20.41 U/L
S.G.P.T.(A.L.T ) : 48.57 U/L
S. Alkaline Phosphatase : 74.77 U/L
S. Protein. : 8.60 gm/dL A : 6.6 - 8.7 gm/dL
S. Albumin : 4.01 gm/dL A : 3.5 - 5.2 gm/dL
S. Globulin : 4.59 gm/dl
A/G. Ratio : 0.87 : 1
HORMONES ANALYSIS REPORT
HORMONE ANALYSIS DONE ON COBAS e411 ELECTRO CHEMILUMINESCENCE & ABBOTT AXSYM SYSTEMS
Investigation Result Unit Reference Range
S. TSH : 2.020 uIU/ml A : 0.27 - 4.2 uIU/ml
reports dtd 28 apr 2010 after 3 weeks of treatment
HAEMATOLOGY
Haematology performed on Fully Automatic 5 part differential COULTER Haematology Analyzer
Investigation Result Unit Reference Range
Haemogram
Haemoglobin. : 14.7 g/dl M : 13 - 18 g/dl
F : 11.5 - 16.5 g/dl
TLC . : 8,300 /c.mm. A : 4000 - 11000 /c.mm.
Differential Leucocyte count
Neutrophils : 57.7 % A : 50 - 80 %
Lymphocytes : 31.7 % A : 25 - 50 %
Monocytes : 7.0 % A : 2 - 10 %
Eosinophils : 3.0 % A : < 6 %
Basophils : 0.6 % A : < 2 %
E.S.R. (Westregen's) : 45 mm/1st Hr
RBC Count 5.29
Packed Cell Volume (Hematocrit) : 42.7 %
Platelets Count. : 217 thousand/cmm A : 150 - 450 thousand/cmm
M.C.V : 81 fl A : 76 - 96 fl
M.C.H : 27.9 pg. A : 27 - 32 pg.
M.C.H.C : 34.5 % A : 30 - 35 %
RDW : 13.9 % A : 11.6 - 14 %
Peripheral Blood Smear :
RBCs are normocytic normochromic. No significant anisopoikilocytosis is seen.
BIO-CHEMISTRY REPORT
Biochemistry tests performed on Fully Automatic ROCHE COBAS 400 INTEGRA & HITACHI 902 / Semi Auto RA-50
/ AVL 9180 / D-10
Investigation Result Unit Reference Range
B. Glucose Fasting. : 75.46 mg/dl A : 70 - 110 mg/dl
Liver Function Test
S. Bilirubin (Total) : 0.22 mg/dL A : < 1 mg/dL
S. Bilirubin (Conjugated) : 0.10 mg/dL A : < 0.6 mg/dL
S. Bilirubin (Unconjugated) : 0.12 mg/dL A : 0.1 - 1 mg/dL
S.G.O.T.(A.S.T) : 32.47 U/L M : < 40 U/L
S.G.P.T.(A.L.T ) : 75.94 U/L M : < 41 U/L
S. Alkaline Phosphatase : 72.14 U/L M : 40 - 129 U/L
S. Protein. : 8.40 gm/dL A : 6.6 - 8.7 gm/dL
S. Albumin : 4.74 gm/dL A : 3.5 - 5.2 gm/dL
S. Globulin : 3.65 gm/dl
A/G. Ratio : 1.30 : 1
Investigation Result
S. TSH : 3.520
regards
rajni jindal 9811035568
pls also give ur specific advice on raised value of SGPT(ALT)- 75.94
wat are its reasons, repercussions on lever and its remedies
do u suggest any change in medicine due to the raised value
Hello!
All the medications he is taking are metabolized in the liver, nothing to worry as his serum bilirubin values are normal.
Give him LIV 52 and Pyridoxine supplements and only go for some rational tests in the future. Monitor his X-rays, ESR which are sufficient.
Take care!
thanx a lot sir
i have few more doubts
kindly give ur views
1.isnt sudden fall of ESR to 45 from 110 within three weeks is noticable?
2.or it may happen?
3.what is the relation of ESR to AKT4?
4.in the report before AKT4 started the Lymphocytes was 22.1(less) but in latest report it is 31.7(within limits). is improvement due to AKT4 medicine?
5.now SGPT(ALT) wl come down or it may rise further?
6.what are the future complications on the health of lever after the AKT 4 course is completed?
7.since akt4 was started, 10 ml (2 times a day)of liv 52 and Pyridoxine 10 mg a day is being given to him. do u suggest any change in it?
8.even than akt4 can effect the liver?
9.can we go for MRI in place of X Rays?
10.is MRI more harmful than X Ray? or X Ray is more harmful?
11.what is the periodicity we go for X Rays/MRI and ESR tests?
sir, i really appreciate ur prompt and very correct response. this is really a human service u r doing to the patients
regards
Hello!
I will answer only relevant questions for your son.
1) ESR denotes his infection with Tuberculosis, but this is not as specific as X-rays.
3) AKT4 is a 4 drug antibiotic which kills the tuberculosis bacteria so all this improvement.
4) Lymphocyte level coming to normal is a good sign
5) SGPT may stabilize and ultimately come to normal if there are no further complications with respect to his liver.
6) Liver is a highly regenerative organ and it can withstand these antibiotics course and after 2-3 months he will only take isoniazid and rifampicin so the load will decrease.
7) Continue the same dose of LIV52 and Pyridoxine.
9) X-rays are enough and you can go for them every month for initial 2 months and then after 3 months. Furthermore 3 X-rays are enough.
10) Let his doctor suggest if he needs anything extra.
Take care!