Having a high Anti-TPO Ab means your thyroid glands keep getting non functional as months, years go by and low thyroid hormones can give symptoms as you are experiencing now. Its beneficial to start on a low dose thyroid hormone pill either levothyroxine or natural dessicated thyroid like 12.5 mcg levothyroxine or 1/4 grain NDT. Though the TSH reference range is broad like .5 to 5.5, normal thyroid gland people's TSH fall under .5 to 1.5.
I was told I had Hashimoto's disease-- anti-tpo was high, but my TSH was also high. When she checked my FT3 and FT4, those numbers were initially out of whack. So, she put me on dessicated thyroid. When I started taking that, my throat started to swell. We've been trying to adjust my numbers and medication levels for 18 months, and when they were finally normal, I still didnt' feel right. Heart racing, tightness in chest (I have low cholesterol, slight drinker -- only 2 a month, no smoking, weight still in normal range, though it doesn't go up or down quickly.) I was feeling tremendous anxiety in the normal ranges, and my anti-tpo is now 248. I definitely don't have answers or even think they treat hashimoto's, other than possibly an ultrasound and looking at your thyroid -- possibly a biopsy to look for cancerous cells or a toxic nodule. On another response to somebody, the following link was recommended: http://www.thyroiduk.org.uk/tuk/TUK_PDFs/diagnosis_and_treatment_of_hypothyroidism_issue_1.pdf