Hi there. Well, I'm not totally sure what you mean it radiates to your knee. You have pain all the way down to your knee? I'd say that is unusual. I've had super uncomfortable menstrual cramps in my life as well as a cyst on my ovary that eventually passed (very painful). I did just weather through with ibuprofen. It does work well for me for relieving pain and discomfort. But if you are concerned or if the pain is super bad, then it might be wise to check in with your doctor. best of luck to you