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Coffee proven to be a liver protector

A study has shown drinking 3 cups of coffee a day can protect the liver from damage. In this studyof hepatitis c subjects, people drank 1 2 or 3 or more cups of coffee a day. Those who drank 3 or more cups also drank more alcohol and smoked more cigarettes than the other groups. The results were the group drinkig the most coffee had the least liver damage despite smoking and drinking the most. It's very promising.

www.hepatitis-central.com/my/archives/2008/11/coffee_drinkers.html
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683664 tn?1330966324
Funny to see your post, was just going to start a thread about coffee.

Tx Week 5.  Have always enjoyed my cup of coffee in the morning, down to one cup these days.  Suddenly I can't tolerate it!  For the past week I've been noticing I throw up after drinking it!!  Have had some serious nausea and all other GI sx, but the coffee seems to really upset my system now.  This morning I drank tea instead, no nausea yet.

What is it about tx and coffee?
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Avatar universal
Here's the paper with a better link. Free Medscape reg may be required.
http://www.medscape.com/viewarticle/583121
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AASLD 2008: High Coffee Consumption May Slow Hepatitis C Progression  CME

From The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)

November 6, 2008 (San Francisco, California) — Increased coffee consumption may slow the progression of liver damage caused by hepatitis C virus infection, researchers reported in a poster here at The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD). Patients who self-reported drinking 3 or more cups of coffee per day were less likely to have liver disease progression than those who drank less coffee daily.

"In population studies, coffee intake has been inversely associated with cirrhosis, chronic liver disease, and hepatocellular carcinoma. But, no studies have examined the relationship between coffee consumption and progression of advanced liver disease," wrote Neal D. Freedman, MD, of the National Cancer Institute at the National Institutes of Health, Department of Health and Human Services, in Rockville, Maryland, and colleagues.

To study this relationship, Freedman analyzed patient questionnaire data about food frequency, including coffee and tea consumption, from the 3.5-year HALT-C randomized trial of 1050 hepatitis C patients at Ishak stage 3 or higher who were unresponsive to standard drug therapies. Some patients in the HALT-C trial received no treatment, and others received 90 µg/week of pegylated interferon alfa-2a.

Of the 808 patients who responded to the questionnaire at baseline, 711 drank zero to 2 cups of coffee a day, and 97 drank 3 or more cups of coffee daily. Those who drank the most coffee also consumed the most alcohol and cigarettes. These coffee drinkers, however, had healthier livers than the other participants, with less steatosis (evaluated by biopsy) and lower bilirubin levels, α-fetoprotein levels, and aspartate aminotransferase/alanine aminotransferase ratios (P < .05).

Liver disease had progressed in 208 patients at the 13-month follow-up, but outcome rates decreased from 10.4/100 person-years (no coffee daily) to 6.0/100 person-years (3 or more cups of coffee daily; P = 0.002). The hazard ratio for coffee consumption ranged from 1.21 (0.81 - 1.79) for no coffee daily to 0.53 (0.29 - 0.95) for 3 or more cups daily (95% confidence intervals; P = .0005). The results show that "coffee consumption may slow the progression of fibrotic liver disease," Freedman wrote in the abstract.

"This is an observational study," Freedman told Medscape Gastroenterology, "so it may be that coffee is a marker for some other activity," he said. "It may be that people who are feeling sicker don't drink as much coffee." He looked at tea drinkers as well but did not find an association between tea consumption and liver disease, he said.

The questionnaire did not ask about the strength of the coffee, what people put in their coffee, or whether people drank caffeinated or decaffeinated coffee, Freedman said. About 85% of coffee consumed nationally is caffeinated. Freedman said that hypotheses about what part of coffee is beneficial to the liver are "pretty speculative" although "maybe the best data is for caffeine." Of the 1000-plus compounds in coffee, several of them may be influencing liver disease, he said.

One advantage of the study was its focus on "the natural history of clinically significant disease progression, which other studies have not been able to do," said Freedman's colleague James Everhart, MD, of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, in Bethesda, Maryland. The study also benefited from a homogenous population. "They all started off with liver disease, so we knew they had liver disease and were able to then look at progression of liver disease from that point on," he told Medscape Gastroenterology.

Actual coffee consumption can be difficult to measure. Samir Rouabhia, MD, from the University Hospital Center Touhami Benflis, Department of Internal Medicine, in Batna, Algeria, said that people tend to drink coffee unevenly. "One day you take one cup and one day you take three cups," he told Medscape Gastroenterology, which makes it difficult to measure coffee's effect on the liver. He also pointed out that it's unclear how the coffee was prepared and how strong it was.

Drs. Freedman, Everhart, and Rouabhia have disclosed no relevant financial relationships. The study received no commercial support.

The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases: Abstract 1778. Presented November 4, 2008.
Pearls for Practice

    * Although patients with hepatitis C virus infection who drank the most coffee (3 or more cups daily) also consumed the most alcohol and cigarettes, they had slower progression of fibrotic liver disease. Hazard ratio for progression of liver disease was 1.21 for no coffee daily to 0.53 for 3 or more cups daily (95% confidence intervals; P = .0005).
    * Those who consumed 3 or more cups of coffee daily had less evidence of liver damage than did other participants with hepatitis C virus infection, with less steatosis on biopsy, and significantly lower bilirubin levels, α-fetoprotein levels, and aspartate aminotransferase/alanine aminotransferase ratios.

CME/CE Test


Medscape Medical News 2008. ©2008 Medscape

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Avatar universal
Organic coffee is best...they dont really know why it helps the liver...its not the caffine because tea dosent have the same effect...tea is also good for the live too tho...they first thought it was the antioxandants in the coffee...but tea has that too...there proberly is something in coffee not yet fully understood....i drink my coffee with distilled water...organic milk and organic sugar....best cup of coffee on the planet
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476246 tn?1418870914
No coffee for me  :-)
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Avatar universal
One thing that popped into my mind was the potential association between coffee and insulin resistance, as I did read that coffee was beneficial with type II Diabetes
http://www.liversupport.com/wordpress/2006/06/coffees-liver-benefits/

That said, a further Google shows article running ten to one against coffee -- i.e. coffee makes IR worse.

Maybe our IR Maven, CO, will chime in but hopefully not to tell us that IR is also the cause of the recent stock market crash :)

Not sure if the coffee studies broke out Steatosis independently of HCC, but that would be helpful in figuring out why coffee seems to help with HCC. Meanwhile, I will continue to drink my coffee WITHOUT sugar. Rock.."organic" sugar...what you thinking here. LOL.

-- Jim
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Avatar universal
" I will continue to drink my coffee WITHOUT sugar"
Jim, I suspect your coffee is flown in weekly, only organic, picked and prepared by only union scale laborers....I doubt it would require sugar...
:^)
-pro
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Avatar universal
I was going to post some info on the organic sugar...but it seems too many closed minded people  on this fourm...sorry...no more talking bout health foods for me...ill stick with the SOC drug tallk and my BOC progress reports and keep ya all up to date...and ill crack the odd  fuuny remake now and then....that is one thing i WILL not STOP
Helpful - 0
Avatar universal
THIS is not directed at anyone in particlualr Jim...just the whole damn world...I GIVE UP
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626749 tn?1256515702
My Dr explained coffee is a very strong substance to put thru your system every day.
It sounded reasonable to me, so stopped cold turkey. Had the headache from H E L L for a few days. Now 5 mo latter don't miss it to much.
I only drank organic French roast from whole foods, sometimes with a little organic milk, no sugar, 1 big, real strong cup, in the morning, mmmm.

IMO, if on tx, why chance anything extra that has not been tested with peg and riba therapy.  Probably wont hurt, but with out a study we don't know.  
Don't know about you guys, on TX my metabolism seems to be working in overdrive. My resting heart rate is up 10-20 beats per minute on tx. Pre tx it use to be 62-65. On tx don't feel like my body needs any more metabolic work from any added substances needing to be metabolized.

jmho
apache

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683664 tn?1330966324
Thanks for responding to my question.  I also feel really ramped up metabolically.  I don't miss the effect of the coffee, just the comfort of it, but a cup of Earl Grey worked fine!   I think I'll stick with tea for now.
Helpful - 0
Avatar universal
Sorry Rock if I hit a sensitive spot -- just thought that "organic sugar" was a bit of an oxymoron like jumbo shrimp or an honest politician. Can't speak for others, but I've always found your take on diet/nutrition interesting and informative and often entertaining. Just doesn't mean I have to agree all the time.

Be well,

-- Jim
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408795 tn?1324935675
Are you supposed to stop drinking coffee during tx?  I could have missed the boat from my medical team or maybe I didn't want to hear, that I would need to stop?  My coffee consumption has gone down to 1 cup max.  I just don't enjoy it the way I used to and I barely picked up on it a couple of days ago.  thx
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Avatar universal
ITS not you my man....i just posted my opinions on the blue green algae...( stem enhance)...and a couple of people call it a scam...i guess i just thought that was a little offenive in my booksI AM NOT A SCAMMER...they could have just said it it woks for me..good...by it think ill past...its frustrating knowing something works ..for me anyway  and my friends and family...and i try to help others...i think some of you know what im talkn about here....im thinking maybe some people think im out to make money or get rich...stupid i say...o well ya cant say i didnt try to help..i did my best
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Avatar universal
Fret: Are you supposed to stop drinking coffee during tx?
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I never said or heard that. Personally, I couldn't drink any coffee on treatment because of significant GERD (chronic reflux). Post treatment I do enjoy coffee and perhaps even more because in a sense it reminds me I'm back to normal and not on treatment anymore! But back to you concern -- if coffee agrees with you on treatment I don't see why you shouldn't drink it. On the other hand, if you lose your taste for it, then don't.

-- Jim

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408795 tn?1324935675
No I don't remember it being said that I would have to stop, but I do notice that my appreciation has gone downhill.  Just making sure.


fret
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568322 tn?1370165440
"One thing that popped into my mind was the potential association between coffee and insulin resistance, as I did read that coffee was beneficial with type II Diabetes

Maybe our IR Maven, CO, will chime in but hopefully not to tell us that IR is also the cause of the recent stock market crash :) "

_______________________

ROFL.....it's ALL about insulin resistance, you know that....LOL

Actually, for diabetics, coffee RAISES their blood sugar....and a new study found that  drinking 4 cups of coffee daily, increases their blood sugar by at least 8% ALL DAY LONG, especially after meals.

http://www.gulfnews.com/world/U.S.A/10185569.html

Diabetics are already insulin resistant, and making their blood sugar go up would make it even worse (which, as we know, would worsen the hyperinsulinemia and high levels of insulin make interferon ineffective).

Caffeine has many negative effects....especially during treatment.....  

Have you ever wondered how scientists find diabetic mice to do studies?  No, mice are not given itty bitty questionares asking them if they're diabetic....LOL  Scientists don't go searching for diabetic mice....instead, they take a group of mice and MAKE THEM diabetic by feeding them a toxic substance called ALLOXAN.  Alloxan poisons and kills the insulin-producing cells in the pancreas and that makes the mice diabetic.

Alloxan is produced in the body from caffeine.  The damage done to the pancreas by Alloxan from caffeine is cumulative.  The longer it goes on, and the more caffeine one ingests, the more damage is done.  

Caffeine also stimulates the release of excess stress hormones and interferes with the chemistry in our brain and exacerbates stress, anxiety, panic, insomnia and depression.  

Although caffeine initially gives you a "lift," it may later have the opposite effect as the effects of the caffeine wear off.  It can also make it more difficult to fall asleep and stay asleep. A lack of sleep can worsen depression.

Caffeine can affect blood sugar and fluctuations in blood sugar can be associated with mood changes.

In clinical experiments, scientists induce panic attacks with caffeine.  When panic disorder patients are given a dose of caffeine equal to 4-5 cups of coffee, about half of them experience a panic attack.  So I wonder how many people with Hep C suffer from anxiety and panic attacks caused by coffee.

Caffeine depletes the body of Vitamin B6 and without enough Vitamin B6, our body can't manufacture serotonin.  People who suffer from anxiety and depression, have low serotonin levels.  And as we know, the Hep C virus and treatment can both cause depression.  
  
So if you add HCV +treatment+coffee, you have a higher risk of depression.

And last but not least, when the Hepatitis C virus gets into your body, it tries to increase your metabolism so that it can reproduce more quickly.  And I could have sworn some people said coffee increases their metabolism.

During treatment, I believe that the risk from coffee use is higher than the possible benefit.  Oh yeah....I didn't find any benefits, did I?  LOL

(***Note to all:  I did NOT say go off coffee cold turkey)


To be fair, since the study you quoted is not about the possible effects of coffee during treatment, but about the possibility of liver protection and what may be creating that effect, I will say this...

It can't be from a decrease in IR.  Furthermore, the coffee drinkers in the study included those that drank decaffeinated and caffeinated coffee put together in a group.  So we're talking people who drank 133mg caffeine/cup put in the same group as people who drank 5mg caffeine/cup.  And then they said their biopsies were better.....which ones?  Those of people who drank the real coffee or decaf?  LOL

And as if that wasn't enough...we don't know whether 99% drank decaf and 1% drank caffeinated coffee....LOL  because they didn't note that.

I tend to not believe flawed studies.

Co



Caffeine content:

8 oz of brewed coffee.......133 mg of caffeine.
8 oz of instant coffee........  93 mg of caffeine.
8 oz Decaf.......... 5 mg of caffeine.
Helpful - 0
619930 tn?1260374254
With the exception of one week or so, I have been continuing to drink coffee during treatment.  I'm sure it would have been easier for my liver, but some things are so tough to give up. :)

The following is for entertainment purposes only:

I love coffee, I love tea
I love the java jive and it loves me
Coffee and tea and the java and me
A cup, a cup, a cup, a cup, a cup (boy!)

I love java, sweet and hot
Whoops Mr. Moto, I'm a coffee pot
Shoot the pot and I'll pour me a shot
A cup, a cup, a cup, a cup, a cup

Oh slip me a slug from the wonderful mug
And I'll cut a rug just snug in a jug
A sliced up onion and a raw one
Draw one -
Waiter, waiter, percolator

I love coffee, I love tea
I love the java jive and it loves me
Coffee and tea and the java and me
A cup, a cup, a cup, a cup, a cup

Boston bean (soy beans)
Green bean (cabbage and greens)
I'm not keen about a bean
Unless it is a chili chili bean (boy!)

I love java sweet and hot
Whoops Mr. Moto Im a coffee pot (yeah)
Shoot me the pot and I'll pour me a shot
A cup, a cup, a cup (yeah)

Slip me a slug of the wonderful mug
an I'll cut a rug just as snug in a jug
Drop a nickel in the pot joe
Takin it slow
Waiter, waiter, percolator

I love coffee, I love tea
I love the java jive and it loves me
Coffee and tea and the java and me
A cup, a cup, a cup, a cup, boy!
Helpful - 0
568322 tn?1370165440
"I never said or heard that. Personally, I couldn't drink any coffee on treatment because of significant GERD (chronic reflux)."

I could have sworn that on the "Riba with fat" you said for breakfast you had egg&cheese omelette cooked with butter, hash browns, toast with butter and jelly....and coffee.

But I could be wrong.

Co
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568322 tn?1370165440
You know the part I find very interesting?  Where it says.....


"Those who drank the most coffee also consumed the most ALCOHOL and cigarettes."


The people in the study were in the HALT-C trial.  So if indeed they were drinking alcohol, then somebody didn't do their job.

And they wonder why the HALT-C showed there was no benefit for maintenance?  And they were allowing the patients to drink?

Please tell me it isn't so.

Co

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Avatar universal
I think I've stated in one of these threads that coffee is more times than not linked with diabetes, so really no disagreement if one has diabetes and  if that's what a patient's plan calls for. However, not in every case as per the study referenced below with type II diabetes. But in any case, given the recent paper (and others similar) in AASLD, I think those of us with an increased risk of HCC (liver cancer) should pause before putting down that cup of Java. The jury is by no means in and it does appear it's not necessarily the caffeine since tea does not appear to confer the same benefit. Here's one balanced look at what's in the coffee pot...
http://www.liversupport.com/wordpress/2006/06/coffees-liver-benefits/
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CO: I could have sworn that on the "Riba with fat" you said for breakfast you had egg&cheese omelette cooked with butter, hash browns, toast with butter and jelly....and coffee. But I could be wrong.
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Not just wrong, but profoundly wrong, like with your riba/fat comments. LOL. I doubt if I had more than a half dozen cups of coffee during my 54 weeks of treatment, which is about my daily consumption now -- if you go by the number of shots of expresso in my daily brew!
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Avatar universal
Will that be one lump or two?
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Avatar universal
CO: The people in the study were in the HALT-C trial.  So if indeed they were drinking alcohol, then somebody didn't do their job.

And they wonder why the HALT-C showed there was no benefit for maintenance?  And they were allowing the patients to drink?

Please tell me it isn't so.
--------------
It's probably not so. Yes, the cohort studied was from Halt-C, but it's unclear if the coffee/cig/alcohol consumption was during treatment or before/after. My guess it's the latter.
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626749 tn?1256515702
Yummmm, I am having a 'riba with fat' breakfast 2moro morning.
Might add ham...

Thanks Jim, glad to know that is the breakfast of hepper champions...lol.

apache
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Avatar universal
Please don't wake up the anti-fat during treatment monster in "Co-Writer". LOL. Honestly, my tennis elbow is starting to act up from posting today, so I'm outta here :) And yeah, I had ham AND cheese omelets often. Gotta add a little more sat fat to the riba  u know :)

Be well,

-- Jim
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