long term effects

[Nickmbb]

For the past 6 year, I have been taking 8mg of valium everyday. Fot the past 2 years, I have been having a host of unexplained aches and pains through out my body. My PCP has stress tested me...had an egg done, cant find any reason for the strange aches and pains that seem to plaque my upper body. Someone told me that these may actually be withdraw from valium even though I'm still taking the drug. I asked my PCP about this and he sort of shoe-shoed the idea. He can't explain the pains, but does not think that 8mg of valium could of cause me to tolerrabce and withdraw. Any ideas? Is my PCP just covering his arse?

[J. E. W.]

This sounds to much like cloning to me. Very scarry stuff!!!!! Thats just my oppinion . To many what ifs for me.. Good luck on your journey my friend..   Ill be praying for you..              J.E.W.

[braindead]

How long were you on percs and how much?
I was on 6 to 8 hydro 7.5s, plus 3 or 4 oxy's each day,
for 12-13 months.
There was a point for the first month without,
that I would have paid 8 grand for just the RD.
I'm sure many movie stars went for it repeatedly,
and are continuing but once they get the gene therapy
they'll be surprized to find out they don't want
the drugs anymore.
Do you think people like that will avoid the re-adaptive
treatment and just opt for the Rapid Detox?
Not if they love their mom.

As a matter of course, stars can do crack and heroin
right up till the day before shooting a film now,
go through RD and show up sober on the set.

That's probably why the first place to do it, and the
first local society to be able to afford it, are
in Beverly Hills.

[braindead]

The company licensed to do ot is CITA (www.citabio.com)
CITA Biomedical inc. is a "penny stock" currently at $.0025$/share, but once was at about $.012. It's a good time to buy
it I imagine, but I'm no stock broker. The "ticker" is "DETOX"
on the stock market.
The company is not answering a lot of questions about the gene
therapy though, since it's a packaged deal with the detox.

I so want to do it, but it could be a hoax to get the stock to come up! (woodsuck..woodsuck)
Here you go,...
This is an excerpt of an older study that led to the current
art.
By the way I'm able to get "Buprenex Injectable", any day of
the week at my local Rx. Are you talking about "Subutex", the
U.S. version of the sub-lingual tablet that's called "temgesic"
in mexico??

Anyways the "rapid detox" has been around a while and without
exception buprinorphine is the state of the art, many detox
centers including CITA use it for the detox portion of the treatment. It does take affect within hours and seems
miraculus, so it would be hard to distinguish a clinic
simply using buprenex, and one using it AND gene therapy
to make the change PERMANENT.
It's the "neuro-adaptation" (or re-adaptation) that
"resets" your neuro-receptors, and it is this part that is
heavily licensed, but a lot of clinics are boasting that they
use it when all they do is the buprinorphine and no real
"gene therapy" treatment.
It seems like it would be prime for suckering rich addicts
for 8 grand, and then not even delivering the goods.

I honestly believe CITA has the goods, but how would you
make sure they weren't just giving you some cocktail?

The bottom line is the PET or SPECT (single photon electron
computerized tomography) scan will show a before and after.
But then how do you know it's YOUR PET scan?

I guess I've just become too paranoid and untrusting, if
I could get the procedure then I wouldn't be as paranoid,
then maybe I'd let them do the procedure, but then I wouln't
need it, but then what if it didn't work?(lol)

I'm not sure but I think what they give you is
"GDNF antisense oligoneucleotide ", but there are probably
a half dozen that have been passed.
It's also possible that they inject you with hydrogen peroxide
saturated with nitrous oxide,
if you read the excerpt about what they did to rats in the
animal tests.
They even say below, in "hidden" nerd language,
"pre-treatment with L-N-nitric arginine methylester(10mg/kg)" that they gave the rats an equivilent of you or I injecting 3/4 gram of pure cocaine, chronically, then re-adapted them.
So the same stuff must be used for blow as for opiates.
(arginine methylester is synthetic cocaine)
AKA "ecgonine methyl ester"

CITA is in Beverly Hills, but they have offices in
hospitals around the country.
________________________________________________________________
"[The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats]

Zhou W, Liu H, Xie X.

Ningbo Institute of Microcirculation & Henbane, Ningbo Drug Addiction Research and Treatment Center, Ningbo 315010, China.

OBJECTIVE: To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of nitric oxide synthase on the expression of these genes in the spinal cord, brainstem and frontal cortex during morphine withdrawal, and to observe the effects of GDNF antisense oligoneucleotide (i.c.v) on the morphine withdrawal symptoms in rats. METHODS: The levels of GDNF, GDNFR-alpha and GDNFR-beta mRNA were assayed by reverse transcription polymerase chain reaction (RT-PCR) with the beta-actin mRNA as an internal control. RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence. These genes were decreased at 1 h, increased at 2 h after administration of naloxone in morphine dependent rats. While the GDNF, GDNFR-alpha and GDNFR-beta levels in the frontal cortex were increased significantly at 1, 2 and 4 h after the injection of naloxone during morphine withdrawal. The pre-treatment with L-N-nitric arginine methylester (10 mg/kg), the expressions of GDNF and GDNFR-beta in the spinal cord, both GDNFR-alpha and GDNFR-beta in the frontal cortex were decreased. The expressions of both GDNF and GDNFR-alpha in the frontal cortex were decreased by treatment with MK801 (0.5 mg/kg), and the expressions of GDNF in both the stem and cortex, and GDNFR-beta in the brainstem decreased by treatment with the methyl-scopolamine (0.5 mg/kg). The beta-actin mRNA levels were not different in each group. Moreover, the morphine withdrawal symptoms were attenuated by intracerebroven tricular injection of GDNF antisense oligoneucleotide in 6 hour and 24 hour before naloxone administration in morphine dependent rats. CONCLUSION: The results not only provide direct evidence that the expressions of GDNF and its receptors mRNA in glial cells play an important role in mediating the process of morphine dependence and may be account for the long-term neuro-adaptation associated with morphine dependence, but also suggest that muscarinic receptor, NMDA receptor and nitric oxide pathways may be involved in the expression of GDNF and GDNF receptor genes during morphine withdrawal.

PMID: 11798749 [PubMed - indexed for MEDLINE]"

[wannastop]

Does anyone know if there are any long term effects on the heart??  I was on vicodine for 7+ years, taking 10 or better a day, recently my Dr. found that I had a heart problem, the cause still unknown.  But now that I'm 6 days clean I do feel a difference in my heart beat etc.  And of course I feel so much better, I haven't felt this great in years. Anyways I was just wondering.  Thanks a million.  

God Bless

wannastop

[percsnomas]

Hey, that "gene altering" part I find most interesting.
Firstly, the delay in getting Buprenorphine here is ridiculous....

I read the transcript of an interview between Bill Moyers and Dr. Steve Hyman(studies addiction and directs the national institute of mental health).

One of Moyers' questions was: "So even though drugs have changed the brain, it can be changed back?"

Hymans' Answer              : " I don't think that you can have your brain back just the way it was, but I certainly believe recovery is possible. There are some changes in your brain that may be irreversible, especially the kinds of emotional memories that we talked about, they may really be indelible. But people who have a stroke are able to recover by using other parts of their brain which weren't affected. It seems extreme, but you might think of someone who is addicted almost as if they've had a peculiar kind of stroke, which affects their motivation and self-will."


So with the above in mind, I'd love to read more about this gene-altering procedure.....

Percs
(by the way, I'm in my 6th month off percs(ie. "longer term"), and feeling pretty good)

[braindead]

HEY EVERYBODY
How come no-one's talking about "LONG TERM EFFECTS" and how it AFFECTS you? (lol)

THIS FORUM SAYS "LONG TERM EFFECTS" at the top.
I wanna talk about long term effects, but it seems like everyone
who succesfuly stops, ALSO STOPS COMING TO THIS WEB SITE!
I'm guessing that this is the case because this "long term" forum
seems to be full of people that are talking about being on their
3rd to 30th day of detox.
There are 3 detoxes that are going on, mental, physical and neurolical.
I mentally detoxed when I finally "loved" or rather be doing something else, "I fell out of love with it".
I physically detoxed at around 60 days. "the sh$%s outta my system". Including all metabolites and antitoxin quota my body
learned to make.

Neurologically I am still devastated.
The FDA just recently approved a new type of rapid detox that
they had to pass as a "Package License", which is what happens
when big business gets a new drug through.
The "packaging" can be simply that it comes in two parts, such
as a single prescription that you're required to take two types
of medicines together or it doesn't work, so it all comes in one
box, or in this case they're allowing this new "gene altering"
therapy to be used "as long as they also sell you a detox
program", usualy in-patient. So if you're already detoxed
it's hard to get them to just give you the gene altering meds.

Personally I used buprinorphine sublingual from mexico before the FDA passed the use of buprinex injectable for the WDs.
"Subutex" (the sublingual form) has also passed FDA but is not
being stocked yet by the Rx industry. It is available in Mex
as "Temgesic" and costs about $30-$40 per day to RAPID DETOX
yourself. All you have to do is western union about $400-$600
to your favorite mexican pharmacy on the border and they'll send a runner across. Recieving it is legal as long as you tell
your doctor what you're doing and they agree to "supervise".
"You are taking the drug under supervision of a US Doctor"
As soon as the Rx's have it on the shelf though, then it
becomes less legal to import because they don't want to lose
money.
Right now your doctor CAN prescribe buprinex injectable (IM or
Subcutaneously), but you gotta convince em you know what you're
doing, they don't want to be the ones to "introduce" needles to
you if you haven't already. They come in a vial, strength equal
to 1 1/2 tablets of the sublingual form, but 5 times as effective. I took 4 tabs a day when I used "temgesic"(called "subutex" in USA rx), and one shot a day on buprinex. Buprinex is very affordable, at about $5 a shot, compared with the tablet it's
way cheap. Most expert WD doctors are now willing to let you
try it so don't harp on the mexican rx thing, you don't need to.

For those of you that have never tried it,
IT'S LIKE NOT DETOXING AT ALL!
Except for some very annoying insomnia AFTERWARDS, which my doctor treated initialy with ambien, which worked great but has wd's of it's own, that begin just "by not increasing the dose",
so abien's bad.
Temazapam, a cousin of vallum, does not build much more than an initial tolerance, and few wd's. I was actually fully detoxed
from everything (including withdrawal meds) finally after 9
months. BUT MY BRAIN NEVER RECOVERED. I suffer STILL, from
shakes, spasms, shiiiivvvvers, and mental awkwardness.
That's why I got really interested in this "gene tharapy" thing.

I was convinced that my "receptors" are shot, and along comes
this news brief about the FDA passed a new "gene therapy" for
use "conjunct with rapid detox" where they showed someones
P.E.T. SCAN (positron emmision tomography) of someones normal
brain, someone's brain that was in detox, and their brain after.
Then they show the same "bad" brain after "neuro-re-adaptation"
using this new technique.

SINCE they discovered that YOU NEVER RECOVER YOUR BRAIN ACTIVITY!,
they decided to figure out which "genes" in your brain cells that
you have left(lol),
(which don't regenerate, and never die unless you kill them
of course)
actually get altered by "neuro adaptation" (or "addiction"). Then they introduce some chemical that "deletes or adds a piece of DNA" from your brain cells, and
the living neurons (brain cells), get altered back to the
way they were before neuro adaptation to all the drugs you took.

It can be addative, so all the drugs you've EVER been hooked on,
caused changes to the DNA in YOUR opiate-receptor cells, among
many other receptors!

The thought of being able to "RESET YOUR BRAIN" is awesome.

Don't get discouraged about my still having symptoms after
9 months, either it's rare, or it goes un-noticed, or I'm
a hypocondriac, or it could be in my head.