Thank you very much! I very much appreciate the information.
Ryan, I will talk to my doctor about the 5 mg., 5 mg. 10 mg. dosage. I don't feel that anxious, but I carry a lot of tension in my body.
Thank you again so very much.
Ryan,
I'm not sure how much effect the metabolites Oxazepam and Temazepam have from taking Diazepam from what I've read. It makes it appear from what your saying that the Oxazepam and Temazepam effects occur from dosing Diazepam and I'm not sure if that is completely accurate. From what you write it makes it appear you are essentially taking three drugs but I believe oxazpeam and temazepam are minor metabolites that are rapidly excreted in the urine where diazepam and nordiazepam are what provides the beneficial effect. I don't think taking diazepam is the same as taking essentially 3 drugs-nordiazpeam, serax, and restoril. I am far from knowledgeable on Pharmacokinetics so maybe you can clear up if I am incorrect here.
Some info:
Although diazepam is 99% protein-bound, interactions based on protein binding are not clinically significant. Metabolism of diazepam is primarily hepatic and involves demethylation (involving primarily CYP2C19 and CYP3A4) and 3-hydroxylation (involving primarily CYP3A4)��. Diazepam is extensively metabolized to one major active metabolite desmethyldiazepam and two minor active metabolites temazepam (3-hydroxydiazepam) and oxazepam (3-hydroxy-N-diazepam), with half-lives of 30-100 hours, 9.5-12 hours, and 5-15 hours, respectively.
At therapeutic doses, desmethyldiazepam is found in plasma at concentrations equivalent to those of diazepam. Oxazepam and temazepam plasma concentrations are usually undetectable. The half-life of diazepam is 30-60 hours. These metabolites are subsequently glucuronidated and excreted in the urine.
Some more info:
Pharmacokinetics: Diazepam is rapidly absorbed. Oral bioavailability is approximately 100%, and close to 99% is bound in plasma. The half-life of diazepam is 43±13 hours, but ranges from 40-100 hours if the contribution from active metabolites is included. Diazepam is metabolized to nordiazepam which is an active metabolite with a half-life of 40-99 hours. Temazepam and oxazepam are minor active metabolites of diazepam. Diazepam is excreted in urine mainly as oxazepam conjugate (~33 %), and temazepam conjugate, with only traces of diazepam and nordiazepam.
Bumped up for Ryan. He'll never find it back on page six! ;)
Just do not want this to get lost until Ryan comes back. He knows more about Valium than my doctor. :)