I have bipolar and schitzoaffective disorders. I've been on lithium and it made me a drooling idiot, wellbutrin made me violent, depakote and seroquil caused extreme weight gain, complicating my other health problems. I have a heart valve problem and back, knee and hip/pelvis injuries from a car accident. My psychiatrist said I had to stay on the depakote and seroquil because there is nothing else out there for me, but I don't believe that.