Can meds stop working after a while? If so, how do you know which one? What's the best way to approach that with my doctor? I'm at the max dose for all my meds (abilify, lamictal, and lithium). My doctor feels that therapy will bring me out of it but I'm not so sure. I'm feeling extremely depressed and paranoid along with some other tell tale symptoms, I'm thinking that something isn't working for me but I don't know what.