I can't say I've ever had adrenal fatigue, but I do suffer from bad anxiety-- attacks, phobias. To keep my adrenals from weakening, as long-term anxiety can do, I take ashwagandha, eleuthero, and American ginseng every day. I also take spirulina or barley grass or wheat grass, and I take holy basil when I get real stressed. It hasn't made my anxiety go away, but I haven't gotten a lot of the physiological symptoms most people with anxiety get.