If buprion is Wellbutrin, I took it first thing in the morning and would get a partial effect all day long but at 5 PM it would drop off and a large depression would come in. My pharmacist said that is a problem with Wellbutrin, the strongest effect is what you take that day, and the buildup over the 8 weeks I trialled it did not amount to that much. I guess that is why doc said to go off it cold-turkey when he switched me to another med, which he definitely said I would have to taper from to go off.
off topic from you're question...sorry. But, I'm currently on the same med bupropion XL, only 150 for the past 3 weeks and I was wondering since you have been taking it longer, how long till you started feeling any help w/ the depression?? I'm waiting for a call back from Doctor(maybe up it?) Also, if this helps, I got mine from CVS and my expierence has been tummy troubles, increased anxiety(which is an effect of it and was my only docs concern about putting me on it, since I take anxiety meds) and loss of appetite(which I hear is normal w/ this med. I've had loss of appetite since I started taking meds this past 10 months, after being in an auto accident. As far as my periods, I have never skipped one, but they are not every 28 days like they used to be(kinda random, like 34days-40+) Maybe the bupropion we'll get them back on cycle?
Take care
Call them and ask your questions. They have a responsibility to both ship the right drug and either they or the manufacturer (who you might end up calling too) must know the side effects.